Dysregulation of mTOR activity through LKB1 inactivation. - Wikidata - thesis-toulmin - TriplyDB

Dysregulation of mTOR activity through LKB1 inactivation.

Dysregulation of mTOR activity through LKB1 inactivation.

http://www.wikidata.org/entity/Q37354026

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Disruptive chemicals, senescence and immortality The functional sites of miRNAs and lncRNAs in gastric carcinogenesis Phase I combination of pazopanib and everolimus in PIK3CA mutation positive/PTEN loss patients with advanced solid tumors refractory to standard therapy.2-Deoxyglucose Suppresses ERK Phosphorylation in LKB1 and Ras Wild-Type Non-Small Cell Lung Cancer Cells.Metformin targets multiple signaling pathways in cancer.LKB1 Tumor Suppressor: Therapeutic Opportunities Knock when LKB1 Is Inactivated.LKB1/AMPK pathway mediates resistin-induced cardiomyocyte hypertrophy in H9c2 embryonic rat cardiomyocytes.A genetic screen identifies an LKB1-MARK signalling axis controlling the Hippo-YAP pathway.Two novel STK11 missense mutations induce phosphorylation of S6K and promote cell proliferation in Peutz-Jeghers syndrome.Response to rapamycin analogs but not PD-1 inhibitors in PTEN-mutated metastatic non-small-cell lung cancer with high tumor mutational burden.

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Dysregulation of mTOR activity through LKB1 inactivation.

http://www.wikidata.org/entity/Q37354026

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on 14 May 2013

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Dysregulation of mTOR activity through LKB1 inactivation.

@en

Dysregulation of mTOR activity through LKB1 inactivation.

@nl

type

label

Dysregulation of mTOR activity through LKB1 inactivation.

@en

Dysregulation of mTOR activity through LKB1 inactivation.

@nl

prefLabel

Dysregulation of mTOR activity through LKB1 inactivation.

@en

Dysregulation of mTOR activity through LKB1 inactivation.

@nl

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Chinese Journal of Cancer

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Dysregulation of mTOR activity through LKB1 inactivation.

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Adam I Marcus

http://www.w3.org/2001/XMLSchema#string

Paula M Vertino

http://www.w3.org/2001/XMLSchema#string

Wei Zhou

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Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported

P2860

Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade

The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death

MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm

Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis

The regulation of AMP-activated protein kinase by phosphorylation

LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

Germline and somatic mutations of the STK11/LKB1 Peutz-Jeghers gene in pancreatic and biliary cancers

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427-433

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scholarly article

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10.5732/CJC.013.10086

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8

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32

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2013-05-14T00:00:00Z

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2013-08-01T00:00:00Z

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236738857

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23668926

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3845579

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