Small molecule chloropyramine hydrochloride (C4) targets the binding site of focal adhesion kinase and vascular endothelial growth factor receptor 3 and suppresses breast cancer growth in vivo.
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FAK and paxillin, two potential targets in pancreatic cancerAltering FAK-paxillin interactions reduces adhesion, migration and invasion processesInhibiting the interaction of cMET and IGF-1R with FAK effectively reduces growth of pancreatic cancer cells in vitro and in vivoInhibition of FAK and VEGFR-3 binding decreases tumorigenicity in neuroblastoma.Targeting focal adhesion kinase in neuroblastoma.Pharmacokinetic analysis of the FAK scaffold inhibitor C4 in dogsDesign, synthesis, and biological evaluation of novel FAK scaffold inhibitors targeting the FAK-VEGFR3 protein-protein interaction.A FAK scaffold inhibitor disrupts FAK and VEGFR-3 signaling and blocks melanoma growth by targeting both tumor and endothelial cellsDisruption of the protein interaction between FAK and IGF-1R inhibits melanoma tumor growth.Focal adhesion kinase overexpression and its impact on human osteosarcoma.Disrupting the scaffold to improve focal adhesion kinase-targeted cancer therapeuticsEfficacy of focal adhesion kinase inhibition in non-small cell lung cancer with oncogenically activated MAPK pathways.Inhibition of the focal adhesion kinase and vascular endothelial growth factor receptor-3 interaction leads to decreased survival in human neuroblastoma cell lines.Targeting the p53 pathway.The FAK scaffold inhibitor C4 disrupts FAK-VEGFR-3 signaling and inhibits pancreatic cancer growth.SASH1 mediates sensitivity of breast cancer cells to chloropyramine and is associated with prognosis in breast cancer.Targeting FAK in human cancer: from finding to first clinical trials.Emerging roles of focal adhesion kinase in cancer.Disrupting the scaffold, an alternative approach to inhibiting FAK.The discovery of new and more potent chloropyramine (C4) analogues for the potential treatment of invasive breast cancer.Targeting CXCR4 and FAK reverses doxorubicin resistance and suppresses invasion in non-small cell lung carcinoma.Targeting Focal Adhesion Kinase Using Inhibitors of Protein-Protein Interactions
P2860
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P2860
Small molecule chloropyramine hydrochloride (C4) targets the binding site of focal adhesion kinase and vascular endothelial growth factor receptor 3 and suppresses breast cancer growth in vivo.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on August 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Small molecule chloropyramine ...... breast cancer growth in vivo.
@en
Small molecule chloropyramine hydrochloride
@nl
type
label
Small molecule chloropyramine ...... breast cancer growth in vivo.
@en
Small molecule chloropyramine hydrochloride
@nl
prefLabel
Small molecule chloropyramine ...... breast cancer growth in vivo.
@en
Small molecule chloropyramine hydrochloride
@nl
P2093
P2860
P356
P1476
Small molecule chloropyramine ...... s breast cancer growth in vivo
@en
P2093
Darell L Hunt
David A Ostrov
Elena V Kurenova
William G Cance
P2860
P304
P356
10.1021/JM900159G
P407
P577
2009-08-01T00:00:00Z