Cell cycle arrest enhances the in vitro cellular toxicity of the truncated Machado-Joseph disease gene product with an expanded polyglutamine stretch.
about
Ataxin-3 interactions with rad23 and valosin-containing protein and its associations with ubiquitin chains and the proteasome are consistent with a role in ubiquitin-mediated proteolysisA novel GTPase, CRAG, mediates promyelocytic leukemia protein-associated nuclear body formation and degradation of expanded polyglutamine proteinSilencing mutant ataxin-3 rescues motor deficits and neuropathology in Machado-Joseph disease transgenic miceLentivector-mediated rescue from cerebellar ataxia in a mouse model of spinocerebellar ataxia.Histone deacetylase inhibitors reduce polyglutamine toxicityProtein-misfolding diseases and chaperone-based therapeutic approaches.The other side of the orexins: endocrine and metabolic actions.A mutant ataxin-3 fragment results from processing at a site N-terminal to amino acid 190 in brain of Machado-Joseph disease-like transgenic mice.Unique pharmacological actions of atypical neuroleptic quetiapine: possible role in cell cycle/fate controlExpansion of the polyQ repeats in THAP11 forms intranuclear aggregation and causes cell G0/G1 arrest.Modulating huntingtin half-life alters polyglutamine-dependent aggregate formation and cell toxicity.Ataxin-2 mediated cell death is dependent on domains downstream of the polyQ repeat.
P2860
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P2860
Cell cycle arrest enhances the in vitro cellular toxicity of the truncated Machado-Joseph disease gene product with an expanded polyglutamine stretch.
description
2000 nî lūn-bûn
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2000年の論文
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2000年学术文章
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2000年学术文章
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name
Cell cycle arrest enhances the ...... xpanded polyglutamine stretch.
@en
type
label
Cell cycle arrest enhances the ...... xpanded polyglutamine stretch.
@en
prefLabel
Cell cycle arrest enhances the ...... xpanded polyglutamine stretch.
@en
P2093
P356
P1476
Cell cycle arrest enhances the ...... xpanded polyglutamine stretch.
@en
P2093
F Shibasaki
I Kanazawa
T Yoshizawa
Y Yamagishi
P356
10.1093/HMG/9.1.69
P577
2000-01-01T00:00:00Z