Functional roles for the pleckstrin and Dbl homology regions in the Ras exchange factor Son-of-sevenless.
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The Grb2-mSos1 complex binds phosphopeptides with higher affinity than Grb2Regulation of Sos activity by intramolecular interactions.N terminus of Sos1 Ras exchange factor: critical roles for the Dbl and pleckstrin homology domainsThe endocytic protein intersectin is a major binding partner for the Ras exchange factor mSos1 in rat brainA mutation in the SOS1 gene causes hereditary gingival fibromatosis type 1Identification of the mitogen-activated protein kinase phosphorylation sites on human Sos1 that regulate interaction with Grb2Grb2 is a negative modulator of the intrinsic Ras-GEF activity of hSos1The solution structure of the pleckstrin homology domain of human SOS1. A possible structural role for the sequential association of diffuse B cell lymphoma and pleckstrin homology domainsInteractions between Src homology (SH) 2/SH3 adapter proteins and the guanylnucleotide exchange factor SOS are differentially regulated by insulin and epidermal growth factorThe role of the PH domain in the signal-dependent membrane targeting of Sos.The isoform-specific stretch of hSos1 defines a new Grb2-binding domain.One-way membrane trafficking of SOS in receptor-triggered Ras activation.The multisubstrate adapter Gab1 regulates hepatocyte growth factor (scatter factor)-c-Met signaling for cell survival and DNA repairInsulin stimulation of a MEK-dependent but ERK-independent SOS protein kinasePhosphatidic acid signaling regulation of Ras superfamily of small guanosine triphosphatases.Regulation of ras exchange factors and cellular localization of ras activation by lipid messengers in T cells.HSos1 contains a new amino-terminal regulatory motif with specific binding affinity for its pleckstrin homology domain.Interferon gamma activation of Raf-1 is Jak1-dependent and p21ras-independent.alphaPix stimulates p21-activated kinase activity through exchange factor-dependent and -independent mechanisms.Signal characteristics of G protein-transactivated EGF receptor.Protein kinase D activation by mutations within its pleckstrin homology domain.Isoform-specific insertion near the Grb2-binding domain modulates the intrinsic guanine nucleotide exchange activity of hSos1.Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway.Specific role for the PH domain of dynamin-1 in the regulation of rapid endocytosis in adrenal chromaffin cells.Structure-based mutagenesis reveals distinct functions for Ras switch 1 and switch 2 in Sos-catalyzed guanine nucleotide exchange.Isolated Sos1 PH domain exhibits germinal vesicle breakdown-inducing activity in Xenopus oocytes.Scratching the surface with the PH domain.Epidermal Growth Factor Receptor Targeting Prevents Uncoupling of the Grb2-SOS Complex
P2860
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P2860
Functional roles for the pleckstrin and Dbl homology regions in the Ras exchange factor Son-of-sevenless.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
1995年论文
@zh
1995年论文
@zh-cn
name
Functional roles for the pleck ...... hange factor Son-of-sevenless.
@en
type
label
Functional roles for the pleck ...... hange factor Son-of-sevenless.
@en
prefLabel
Functional roles for the pleck ...... hange factor Son-of-sevenless.
@en
P2093
P2860
P356
P1476
Functional roles for the pleck ...... hange factor Son-of-sevenless.
@en
P2093
Banerjee U
Karlovich CA
McCollam L
P2860
P304
15954-15957
P356
10.1074/JBC.270.27.15954
P407
P577
1995-07-01T00:00:00Z