about
"Natural Regulators": NK Cells as Modulators of T Cell ImmunityCbl-mediated negative regulation of the Syk tyrosine kinase. A critical role for Cbl phosphotyrosine-binding domain binding to Syk phosphotyrosine 323A natural genetic variant of granzyme B confers lethality to a common viral infectionThe two major sites of cbl tyrosine phosphorylation in abl-transformed cells select the crkL SH2 domainAssociation of p59(fyn) with the T lymphocyte costimulatory receptor CD2. Binding of the Fyn Src homology (SH) 3 domain is regulated by the Fyn SH2 domain.Innate immunity defines the capacity of antiviral T cells to limit persistent infectionCD83 increases MHC II and CD86 on dendritic cells by opposing IL-10-driven MARCH1-mediated ubiquitination and degradation.MCMV-mediated inhibition of the pro-apoptotic Bak protein is required for optimal in vivo replicationPeripheral natural killer cell maturation depends on the transcription factor AiolosNK cells require IL-28R for optimal in vivo activityCross-talk between dendritic cells and natural killer cells in viral infection.A novel checkpoint in the Bcl-2-regulated apoptotic pathway revealed by murine cytomegalovirus infection of dendritic cells.The early kinetics of cytomegalovirus-specific CD8+ T-cell responses are not affected by antigen load or the absence of perforin or gamma interferonNatural killer cells in viral infection: more than just killers.A chemokine-like viral protein enhances alpha interferon production by plasmacytoid dendritic cells but delays CD8+ T cell activation and impairs viral clearance.Killers and beyond: NK-cell-mediated control of immune responses.Suicide watch: how cytomegalovirus interferes with the cell-death pathways of infected cells.Loss of c-Cbl RING finger function results in high-intensity TCR signaling and thymic deletion.Cathepsin C limits acute viral infection independently of NK cell and CD8+ T-cell cytolytic function.CIS is a potent checkpoint in NK cell-mediated tumor immunity.Die Another Day: Inhibition of Cell Death Pathways by Cytomegalovirus.Acute GVHD results in a severe DC defect that prevents T-cell priming and leads to fulminant cytomegalovirus disease in mice.Deficient NLRP3 and AIM2 Inflammasome Function in Autoimmune NZB Mice.TRAIL+ NK cells control CD4+ T cell responses during chronic viral infection to limit autoimmunity.The Cbl protooncogene product: from an enigmatic oncogene to center stage of signal transduction.The early monocytic response to cytomegalovirus infection is MyD88 dependent but occurs independently of common inflammatory cytokine signals.Interaction between conventional dendritic cells and natural killer cells is integral to the activation of effective antiviral immunity.Virally mediated inhibition of Bax in leukocytes promotes dissemination of murine cytomegalovirus.CpG pretreatment enhances antiviral T-cell immunity against cytomegalovirus.Ocular antigen does not cause disease unless presented in the context of inflammation.The Murine Natural Cytotoxic Receptor NKp46/NCR1 Controls TRAIL Protein Expression in NK Cells and ILC1s.Cytomegalovirus establishes a latent reservoir and triggers long-lasting inflammation in the eye.The RING Finger Domain of Cbl Is Essential for Negative Regulation of the Syk Tyrosine KinaseThe roles of interferon-γ and perforin in antiviral immunity in mice that differ in genetically determined NK-cell-mediated antiviral activityInfection of dendritic cells by murine cytomegalovirus induces functional paralysisMurine cytomegalovirus infection exacerbates complex IV deficiency in a model of mitochondrial diseaseStrain-specific antibody therapy prevents cytomegalovirus reactivation after transplantationThe Avidity Game: Selecting Natural-Born KillersASC modulates CTL cytotoxicity and transplant outcome independent of the inflammasome
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Christopher E Andoniou
@ast
Christopher E Andoniou
@en
Christopher E Andoniou
@es
Christopher E Andoniou
@nl
Christopher E Andoniou
@sl
type
label
Christopher E Andoniou
@ast
Christopher E Andoniou
@en
Christopher E Andoniou
@es
Christopher E Andoniou
@nl
Christopher E Andoniou
@sl
prefLabel
Christopher E Andoniou
@ast
Christopher E Andoniou
@en
Christopher E Andoniou
@es
Christopher E Andoniou
@nl
Christopher E Andoniou
@sl
P106
P21
P31
P496
0000-0003-0566-3180