The RING Finger Domain of Cbl Is Essential for Negative Regulation of the Syk Tyrosine Kinase
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Functional cloning of Src-like adapter protein-2 (SLAP-2), a novel inhibitor of antigen receptor signalingRegulation of Cbl molecular interactions by the co-receptor molecule CD43 in human T cellsNegative regulation of Lck by Cbl ubiquitin ligasec-Cbl facilitates fibronectin matrix production by v-Abl-transformed NIH3T3 cells via activation of small GTPasesTULA: an SH3- and UBA-containing protein that binds to c-Cbl and ubiquitin.T cell activation induces direct binding of the Crk adapter protein to the regulatory subunit of phosphatidylinositol 3-kinase (p85) via a complex mechanism involving the Cbl protein.Negative feedback control of osteoclast formation through ubiquitin-mediated down-regulation of NFATc1.The linker for activation of B cells (LAB)/non-T cell activation linker (NTAL) regulates triggering receptor expressed on myeloid cells (TREM)-2 signaling and macrophage inflammatory responses independently of the linker for activation of T cells.Interaction of c-Cbl with myosin IIA regulates Bleb associated macropinocytosis of Kaposi's sarcoma-associated herpesvirus.D-Cbl binding to Drk leads to dose-dependent down-regulation of EGFR signaling and increases receptor-ligand endocytosis.Cbl-b-dependent coordinated degradation of the epidermal growth factor receptor signaling complex.A positive regulatory role for Cbl family proteins in tumor necrosis factor-related activation-induced cytokine (trance) and CD40L-mediated Akt activation.Cbl: many adaptations to regulate protein tyrosine kinases.Beyond the RING: CBL proteins as multivalent adapters.Ig beta tyrosine residues contribute to the control of B cell receptor signaling by regulating receptor internalization.EphrinA2 regulates clathrin mediated KSHV endocytosis in fibroblast cells by coordinating integrin-associated signaling and c-Cbl directed polyubiquitinationA critical role for the E3-ligase activity of c-Cbl in VEGFR-2-mediated PLCgamma1 activation and angiogenesis.Src-like adaptor protein (SLAP) regulates B cell receptor levels in a c-Cbl-dependent manner.Constitutive endocytosis and degradation of the pre-T cell receptor.Signaling threshold regulation by the Ras effector IMP.c-Cbl tyrosine kinase-binding domain mutant G306E abolishes the interaction of c-Cbl with CD38 and fails to promote retinoic acid-induced cell differentiation and G0 arrestCbl proteins in platelet activation.Modulation of Immune Cell Functions by the E3 Ligase Cbl-b.Structural Determinants of the Gain-of-Function Phenotype of Human Leukemia-associated Mutant CBL Oncogene.Loss of c-Cbl RING finger function results in high-intensity TCR signaling and thymic deletion.Differential subcellular localization regulates c-Cbl E3 ligase activity upon Notch3 protein in T-cell leukemia.Biochemical basis for the requirement of kinase activity for Cbl-dependent ubiquitinylation and degradation of a target tyrosine kinase.Cbl promotes ubiquitination of the T cell receptor zeta through an adaptor function of Zap-70.DPP9 is a novel component of the N-end rule pathway targeting the tyrosine kinase Syk.CD43 regulates the threshold for T cell activation by targeting Cbl functions.Cbl-mediated ubiquitinylation and negative regulation of Vav.Src-like adaptor protein regulates TCR expression on thymocytes by linking the ubiquitin ligase c-Cbl to the TCR complex.Transforming growth factor-beta1 inhibition of vascular smooth muscle cell activation is mediated via Smad3.Striated muscle preferentially expressed genes alpha and beta are two serine/threonine protein kinases derived from the same gene as the aortic preferentially expressed gene-1.
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The RING Finger Domain of Cbl Is Essential for Negative Regulation of the Syk Tyrosine Kinase
description
article publié dans la revue scientifique Journal of Biological Chemistry
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im Januar 2000 veröffentlichter wissenschaftlicher Artikel
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scientific article published in Journal of Biological Chemistry
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wetenschappelijk artikel
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наукова стаття, опублікована в січні 2000
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name
The RING Finger Domain of Cbl ...... ion of the Syk Tyrosine Kinase
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The RING Finger Domain of Cbl ...... ion of the Syk Tyrosine Kinase
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type
label
The RING Finger Domain of Cbl ...... ion of the Syk Tyrosine Kinase
@en
The RING Finger Domain of Cbl ...... ion of the Syk Tyrosine Kinase
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prefLabel
The RING Finger Domain of Cbl ...... ion of the Syk Tyrosine Kinase
@en
The RING Finger Domain of Cbl ...... ion of the Syk Tyrosine Kinase
@nl
P2093
P2860
P356
P1476
The RING finger domain of Cbl ...... ion of the Syk tyrosine kinase
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P2093
P2860
P304
P356
10.1074/JBC.275.1.414
P407
P577
2000-01-01T00:00:00Z