Homo- and heterodimerization of APP family members promotes intercellular adhesion.Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasisAmyloid-beta-anti-amyloid-beta complex structure reveals an extended conformation in the immunodominant B-cell epitopeCrystal structure of the human Fe65-PTB1 domainStructure of the intracellular domain of the amyloid precursor protein in complex with Fe65-PTB2Evidence for a copper-binding superfamily of the amyloid precursor proteinThe proteolytic processing of the amyloid precursor protein gene family members APLP-1 and APLP-2 involves alpha-, beta-, gamma-, and epsilon-like cleavages: modulation of APLP-1 processing by n-glycosylationAPP anterograde transport requires Rab3A GTPase activity for assembly of the transport vesicle.Mechanisms of peripheral microvascular dysfunction in transgenic mice overexpressing the Alzheimer's disease amyloid Abeta protein.The intramembrane cleavage site of the amyloid precursor protein depends on the length of its transmembrane domain.Platelet alpha- and gamma-synucleins in Parkinson's disease and normal control subjects.Detrimental effects of arachidonic acid and its metabolites in cellular and mouse models of Alzheimer's disease: structural insight.Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial.PAT1a modulates intracellular transport and processing of amyloid precursor protein (APP), APLP1, and APLP2.Delineating common molecular mechanisms in Alzheimer's and prion diseases.Alzheimer's centennial legacy: prospects for rational therapeutic intervention targeting the Abeta amyloid pathway.Subcellular trafficking of the amyloid precursor protein gene family and its pathogenic role in Alzheimer's disease.Mercury-induced crystallization and SAD phasing of the human Fe65-PTB1 domain.Overproduction, purification, crystallization and preliminary X-ray analysis of human Fe65-PTB2 in complex with the amyloid precursor protein intracellular domain.A presenilin 1 mutation in the first case of Alzheimer's disease: revisited.Independent inhibition of Alzheimer disease beta- and gamma-secretase cleavage by lowered cholesterol levels.Tenuigenin treatment decreases secretion of the Alzheimer's disease amyloid beta-protein in cultured cells.Alzheimer beta-amyloid homodimers facilitate A beta fibrillization and the generation of conformational antibodies.APP intracellular domain is increased and soluble Abeta is reduced with diet-induced hypercholesterolemia in a transgenic mouse model of Alzheimer disease.Structural insight into the differential effects of omega-3 and omega-6 fatty acids on the production of Abeta peptides and amyloid plaques.Cerebrospinal fluid 24S-hydroxycholesterol is increased in patients with Alzheimer's disease compared to healthy controls.Toxicity of substrate-bound amyloid peptides on vascular smooth muscle cells is enhanced by homocysteine.Profile of cholesterol-related sterols in aged amyloid precursor protein transgenic mouse brain.Increased expression of the amyloid precursor beta-secretase in Alzheimer's disease.Treatment with simvastatin in normocholesterolemic patients with Alzheimer's disease: A 26-week randomized, placebo-controlled, double-blind trial.The transmembrane domain of the amyloid precursor protein in microsomal membranes is on both sides shorter than predicted.Selecting cells with different Alzheimer's disease gamma-secretase activity using FACS. Differential effect on presenilin exon 9 gamma- and epsilon-cleavage.No alterations of hippocampal neuronal number and synaptic bouton number in a transgenic mouse model expressing the beta-cleaved C-terminal APP fragment.Iron inhibits neurotoxicity induced by trace copper and biological reductants.Tyrosine gated electron transfer is key to the toxic mechanism of Alzheimer's disease beta-amyloid.Alternative transcripts of presenilin-1 associated with frontotemporal dementia.A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing.Locomotor activity and evoked dopamine release are reduced in mice overexpressing A30P-mutated human alpha-synuclein.Diverse fibrillar peptides directly bind the Alzheimer's amyloid precursor protein and amyloid precursor-like protein 2 resulting in cellular accumulation.GM1 up-regulates Ubiquilin 1 expression in human neuroblastoma cells and rat cortical neurons.
P50
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P50
description
Duits moleculair bioloog
@nl
German molecular biologist and chemist
@en
chimiste allemand
@fr
deutscher Molekularbiologe
@de
professor académico alemão
@pt
tysk professor
@da
tysk professor
@sv
name
Konrad Beyreuther
@ast
Konrad Beyreuther
@ca
Konrad Beyreuther
@da
Konrad Beyreuther
@de
Konrad Beyreuther
@en
Konrad Beyreuther
@es
Konrad Beyreuther
@fr
Konrad Beyreuther
@nb
Konrad Beyreuther
@nds
Konrad Beyreuther
@nl
type
label
Konrad Beyreuther
@ast
Konrad Beyreuther
@ca
Konrad Beyreuther
@da
Konrad Beyreuther
@de
Konrad Beyreuther
@en
Konrad Beyreuther
@es
Konrad Beyreuther
@fr
Konrad Beyreuther
@nb
Konrad Beyreuther
@nds
Konrad Beyreuther
@nl
altLabel
كونراد باي رويثر
@ar
كونراد ت. باي رويثر
@ar
prefLabel
Konrad Beyreuther
@ast
Konrad Beyreuther
@ca
Konrad Beyreuther
@da
Konrad Beyreuther
@de
Konrad Beyreuther
@en
Konrad Beyreuther
@es
Konrad Beyreuther
@fr
Konrad Beyreuther
@nb
Konrad Beyreuther
@nds
Konrad Beyreuther
@nl