Inhibition of stearoylCoA desaturase-1 inactivates acetyl-CoA carboxylase and impairs proliferation in cancer cells: role of AMPK
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Human breast cancer tissues contain abundant phosphatidylcholine(36∶1) with high stearoyl-CoA desaturase-1 expressionHigh stearoyl-CoA desaturase 1 expression is associated with shorter survival in breast cancer patientsAberrant Lipid Metabolism Promotes Prostate Cancer: Role in Cell Survival under Hypoxia and Extracellular Vesicles BiogenesisO-GlcNAcylation and the Metabolic Shift in High-Proliferating Cells: All the Evidence Suggests that Sugars Dictate the Flux of Lipid Biogenesis in Tumor ProcessesA novel approach to the discovery of anti-tumor pharmaceuticals: searching for activators of liponecrosisMolecular mechanisms for survival regulation of chronic myeloid leukemia stem cellsBroad Anti-tumor Activity of a Small Molecule that Selectively Targets the Warburg Effect and LipogenesisSpheres derived from lung adenocarcinoma pleural effusions: molecular characterization and tumor engraftmentCritical role of SCD1 in autophagy regulation via lipogenesis and lipid rafts-coupled AKT-FOXO1 signaling pathway.Inhibition of stearoylCoA desaturase activity blocks cell cycle progression and induces programmed cell death in lung cancer cellsInhibition of stearoyl-CoA desaturase 1 expression induces CHOP-dependent cell death in human cancer cells.Allosteric inhibition of a stem cell RNA-binding protein by an intermediary metabolite.Loss of HSulf-1 promotes altered lipid metabolism in ovarian cancerStearoylCoA desaturase-5: a novel regulator of neuronal cell proliferation and differentiation.Drosophila Myc: A master regulator of cellular performance.Stearoyl-coenzyme A desaturase 1 inhibition and the metabolic syndrome: considerations for future drug discoveryMacrophage migration inhibitory factor and stearoyl-CoA desaturase 1: potential prognostic markers for soft tissue sarcomas based on bioinformatics analyses.Stearoyl-CoA desaturase 1 and paracrine diffusible signals have a major role in the promotion of breast cancer cell migration induced by cancer-associated fibroblastsGenetic variants within ultraconserved elements and susceptibility to right- and left-sided colorectal adenocarcinoma.Scd1 plays a tumor-suppressive role in survival of leukemia stem cells and the development of chronic myeloid leukemia.Global Gene Expression Profiling in PPAR-γ Agonist-Treated Kidneys in an Orthologous Rat Model of Human Autosomal Recessive Polycystic Kidney DiseaseDysregulated lipid metabolism in cancer.Progestin modulates the lipid profile and sensitivity of breast cancer cells to docetaxelPalmitic acid (16:0) competes with omega-6 linoleic and omega-3 ɑ-linolenic acids for FADS2 mediated Δ6-desaturation.Stearoyl-CoA desaturase-1 mediated cell apoptosis in colorectal cancer by promoting ceramide synthesis.ras-Induced up-regulation of CTP:phosphocholine cytidylyltransferase α contributes to malignant transformation of intestinal epithelial cells.Yeast and cancer cells - common principles in lipid metabolism.A link between lipid metabolism and epithelial-mesenchymal transition provides a target for colon cancer therapy.Stearoyl-CoA desaturase 1 is a novel molecular therapeutic target for clear cell renal cell carcinoma.Aberrant lipid metabolism: an emerging diagnostic and therapeutic target in ovarian cancer.Chronic exposure to chewing tobacco selects for overexpression of stearoyl-CoA desaturase in normal oral keratinocytes.dMyc expression in the fat body affects DILP2 release and increases the expression of the fat desaturase Desat1 resulting in organismal growth.Fibroblast growth factor 21 deficiency exacerbates chronic alcohol-induced hepatic steatosis and injuryStearoyl-CoA desaturase enzyme 1 inhibition reduces glucose utilization for de novo fatty acid synthesis and cell proliferation in 3T3-L1 adipocytes.Hooked on fat: the role of lipid synthesis in cancer metabolism and tumour development.Role of abnormal lipid metabolism in development, progression, diagnosis and therapy of pancreatic cancer.Stearoyl-CoA desaturase-1: a novel key player in the mechanisms of cell proliferation, programmed cell death and transformation to cancer.Stearoyl CoA desaturase 1: role in cellular inflammation and stressThe role of stearoyl-CoA desaturase in obesity, insulin resistance, and inflammation.Non-glucose metabolism in cancer cells--is it all in the fat?
P2860
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P2860
Inhibition of stearoylCoA desaturase-1 inactivates acetyl-CoA carboxylase and impairs proliferation in cancer cells: role of AMPK
description
2009 nî lūn-bûn
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2009 թուականին հրատարակուած գիտական յօդուած
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2009 թվականին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Inhibition of stearoylCoA desa ...... in cancer cells: role of AMPK
@ast
Inhibition of stearoylCoA desa ...... in cancer cells: role of AMPK
@en
Inhibition of stearoylCoA desa ...... in cancer cells: role of AMPK
@en-gb
Inhibition of stearoylCoA desa ...... in cancer cells: role of AMPK
@nl
type
label
Inhibition of stearoylCoA desa ...... in cancer cells: role of AMPK
@ast
Inhibition of stearoylCoA desa ...... in cancer cells: role of AMPK
@en
Inhibition of stearoylCoA desa ...... in cancer cells: role of AMPK
@en-gb
Inhibition of stearoylCoA desa ...... in cancer cells: role of AMPK
@nl
altLabel
Inhibition of StearoylCoA Desa ...... in Cancer Cells: Role of AMPK
@en
prefLabel
Inhibition of stearoylCoA desa ...... in cancer cells: role of AMPK
@ast
Inhibition of stearoylCoA desa ...... in cancer cells: role of AMPK
@en
Inhibition of stearoylCoA desa ...... in cancer cells: role of AMPK
@en-gb
Inhibition of stearoylCoA desa ...... in cancer cells: role of AMPK
@nl
P2093
P2860
P3181
P1433
P1476
Inhibition of stearoylCoA desa ...... in cancer cells: role of AMPK
@en
P2093
Jeffrey W Chisholm
Natalia Scaglia
R Ariel Igal
P2860
P3181
P356
10.1371/JOURNAL.PONE.0006812
P407
P577
2009-01-01T00:00:00Z