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Noncovalent interaction between Ubc9 and SUMO promotes SUMO chain formationRNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sitesThe ubiquitin ligase Triad1 inhibits myelopoiesis through UbcH7 and Ubc13 interacting domainsStructure and E3-ligase activity of the Ring-Ring complex of polycomb proteins Bmi1 and Ring1bThe conserved molecular machinery in DNA mismatch repair enzyme structuresHuman RAD18 interacts with ubiquitylated chromatin components and facilitates RAD9 recruitment to DNA double strand breaksCrystal structure of the ffh and EF-G binding sites in the conserved domain IV of Escherichia coli 4.5S RNACrystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptorsStructures of Escherichia coli DNA mismatch repair enzyme MutS in complex with different mismatches: a common recognition mode for diverse substratesAChBP-targeted α-conotoxin correlates distinct binding orientations with nAChR subtype selectivityUbc9 sumoylation regulates SUMO target discriminationUse of acetylcholine binding protein in the search for novel alpha7 nicotinic receptor ligands. In silico docking, pharmacological screening, and X-ray analysisMagnesium Coordination Controls the Molecular Switch Function of DNA Mismatch Repair Protein MutSFragment growing induces conformational changes in acetylcholine-binding protein: a structural and thermodynamic analysisE3 ligase Rad18 promotes monoubiquitination rather than ubiquitin chain formation by E2 enzyme Rad6Symmetry and asymmetry of the RING-RING dimer of Rad18Acetylcholine binding protein (AChBP) as template for hierarchical in silico screening procedures to identify structurally novel ligands for the nicotinic receptorsMechanism of USP7/HAUSP activation by its C-terminal ubiquitin-like domain and allosteric regulation by GMP-synthetaseAssembly of a π–π stack of ligands in the binding site of an acetylcholine-binding proteinUsing stable MutS dimers and tetramers to quantitatively analyze DNA mismatch recognition and sliding clamp formation.Structure of USP7 catalytic domain and three Ubl-domains reveals a connector α-helix with regulatory roleA conserved two-step binding for the UAF1 regulator to the USP12 deubiquitinating enzymeGalactose-binding site in Escherichia coli heat-labile enterotoxin (LT) and cholera toxin (CT)Structure of partially-activated E. coli heat-labile enterotoxin (LT) at 2.6 A resolutionStructural basis for dual excitation and photoisomerization of the Aequorea victoria green fluorescent proteinCrystal structure of murine/human Ubc9 provides insight into the variability of the ubiquitin-conjugating systemwARP: improvement and extension of crystallographic phases by weighted averaging of multiple-refined dummy atomic modelsThe RanBP2 SUMO E3 ligase is neither HECT- nor RING-typeThe role of UBL domains in ubiquitin-specific proteasesA genomic and functional inventory of deubiquitinating enzymesNicotine and carbamylcholine binding to nicotinic acetylcholine receptors as studied in AChBP crystal structuresInteraction of alpha-conotoxin ImII and its analogs with nicotinic receptors and acetylcholine-binding proteins: additional binding sites on Torpedo receptor.DNA mismatch repair: MutS structures bound to mismatches.Crystal structure of acetylcholine-binding protein from Bulinus truncatus reveals the conserved structural scaffold and sites of variation in nicotinic acetylcholine receptors.Acetylcholine binding protein (AChBP): a secreted glial protein that provides a high-resolution model for the extracellular domain of pentameric ligand-gated ion channels.Interplay among nucleosomal DNA, histone tails, and corepressor CoREST underlies LSD1-mediated H3 demethylation.Native mass spectrometry provides direct evidence for DNA mismatch-induced regulation of asymmetric nucleotide binding in mismatch repair protein MutS.Human Wrnip1 is localized in replication factories in a ubiquitin-binding zinc finger-dependent manner.Akt-mediated phosphorylation of Bmi1 modulates its oncogenic potential, E3 ligase activity, and DNA damage repair activity in mouse prostate cancer.Functional characterization of Rad18 domains for Rad6, ubiquitin, DNA binding and PCNA modification.
P50
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P50
description
Dutch biochemist and university teacher
@en
Nederlands biochemicus en hoogleraar
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niederländische Biochemikerin
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name
Titia Sixma
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Titia Sixma
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Titia Sixma
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Titia Sixma
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Titia Sixma
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Titia Sixma
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Titia Sixma
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Titia Sixma
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type
label
Titia Sixma
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Titia Sixma
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Titia Sixma
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Titia Sixma
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Titia Sixma
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Titia Sixma
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Titia Sixma
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Titia Sixma
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altLabel
T.K. Sixma
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T.K. Sixma
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Titia K Sixma
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Titia K Sixma
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Titia K Sixma
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prefLabel
Titia Sixma
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Titia Sixma
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Titia Sixma
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Titia Sixma
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Titia Sixma
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Titia Sixma
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Titia Sixma
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Titia Sixma
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P106
P1006
P214
P1006
P2080
P21
P213
0000 0003 9310 7108
P214
P31
P496
0000-0001-6180-0632
P5463
Sixma_Titia
P569
1962-01-01T00:00:00Z
P735
P7859
viaf-287298860