The pRb-related protein p130 is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCF(Skp2). - Wikidata - wikimedia - TriplyDB

The pRb-related protein p130 is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCF(Skp2).

The pRb-related protein p130 is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCF(Skp2).

http://www.wikidata.org/entity/Q35805056

about

The retinoblastoma family of proteins and their regulatory functions in the mammalian cell division cycle Cooperation of ERK and SCFSkp2 for MKP-1 destruction provides a positive feedback regulation of proliferating signaling E2F-1 has dual roles depending on the cell cycle Phosphorylation of Skp2 regulated by CDK2 and Cdc14B protects it from degradation by APC(Cdh1) in G1 phase Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7 Epstein-Barr virus latent antigen 3C can mediate the degradation of the retinoblastoma protein through an SCF cellular ubiquitin ligase The ETS protein MEF is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCFSkp2.B55alpha PP2A holoenzymes modulate the phosphorylation status of the retinoblastoma-related protein p107 and its activation Skp2: a novel potential therapeutic target for prostate cancer Cyclin G2 is degraded through the ubiquitin-proteasome pathway and mediates the antiproliferative effect of activin receptor-like kinase 7 Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer Replication-initiator protein (UL9) of the herpes simplex virus 1 binds NFB42 and is degraded via the ubiquitin-proteasome pathway The association of mammalian DREAM complex and HPV16 E7 proteins PP2A: more than a reset switch to activate pRB proteins during the cell cycle and in response to signaling cues.Network calisthenics: control of E2F dynamics in cell cycle entry PP1 and PP2A phosphatases--cooperating partners in modulating retinoblastoma protein activation The SCF(Skp2) ubiquitin ligase complex interacts with the human replication licensing factor Cdt1 and regulates Cdt1 degradation Role of conformational heterogeneity in domain swapping and adapter function of the Cks proteins Targeting the oncogenic E3 ligase Skp2 in prostate and breast cancer cells with a novel energy restriction-mimetic agent Wogonin has multiple anti-cancer effects by regulating c-Myc/SKP2/Fbw7α and HDAC1/HDAC2 pathways and inducing apoptosis in human lung adenocarcinoma cell line A549 Cul4A targets p27 for degradation and regulates proliferation, cell cycle exit, and differentiation during erythropoiesis Regulation of ischemic neuronal death by E2F4-p130 protein complexes Deregulation of F-box proteins and its consequence on cancer development, progression and metastasis.The balance between cell division and endoreplication depends on E2FC-DPB, transcription factors regulated by the ubiquitin-SCFSKP2A pathway in Arabidopsis.SKP2A, an F-box protein that regulates cell division, is degraded via the ubiquitin pathway.The Arabidopsis thaliana F-box protein FBL17 is essential for progression through the second mitosis during pollen development.Genetic replacement of cyclin D1 function in mouse development by cyclin D2.Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation.Low- and high-risk human papillomavirus E7 proteins regulate p130 differently Integrated stability and activity control of the Drosophila Rbf1 retinoblastoma protein.The emerging role of the COP9 signalosome in cancer.F-box protein FBXO31 is down-regulated in gastric cancer and negatively regulated by miR-17 and miR-20a.The E7 proteins of low- and high-risk human papillomaviruses share the ability to target the pRB family member p130 for degradation The amelioration of renal damage in Skp2-deficient mice canceled by p27 Kip1 deficiency in Skp2-/- p27-/- mice The role of the RB tumour suppressor pathway in oxidative stress responses in the haematopoietic system.The ISG15 isopeptidase UBP43 is regulated by proteolysis via the SCFSkp2 ubiquitin ligase.Ubiquitin-dependent proteolysis in G1/S phase control and its relationship with tumor susceptibility The DREAM complex: master coordinator of cell cycle-dependent gene expression.Cullins and cancer.

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The pRb-related protein p130 is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCF(Skp2).

http://www.wikidata.org/entity/Q35805056

description

2002 nî lūn-bûn

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2002年の論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年论文

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2002年论文

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2002年论文

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name

The pRb-related protein p130 i ...... in-ubiquitin ligase SCF(Skp2).

@ast

The pRb-related protein p130 i ...... in-ubiquitin ligase SCF(Skp2).

@en

type

label

The pRb-related protein p130 i ...... in-ubiquitin ligase SCF(Skp2).

@ast

The pRb-related protein p130 i ...... in-ubiquitin ligase SCF(Skp2).

@en

prefLabel

The pRb-related protein p130 i ...... in-ubiquitin ligase SCF(Skp2).

@ast

The pRb-related protein p130 i ...... in-ubiquitin ligase SCF(Skp2).

@en

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P1433

Genes & Development

P1476

The pRb-related protein p130 i ...... in-ubiquitin ligase SCF(Skp2).

@en

P2093

Donato Tedesco

http://www.w3.org/2001/XMLSchema#string

Steven I Reed

http://www.w3.org/2001/XMLSchema#string

P2860

Comparison of the effectiveness of adenovirus vectors expressing cyclin kinase inhibitors p16INK4A, p18INK4C, p19INK4D, p21(WAF1/CIP1) and p27KIP1 in inducing cell cycle arrest, apoptosis and inhibition of tumorigenicity

Crystal structure and mutational analysis of the human CDK2 kinase complex with cell cycle-regulatory protein CksHs1

Activation of cyclin E/CDK2 is coupled to site-specific autophosphorylation and ubiquitin-dependent degradation of cyclin E

Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression

The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro

The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase

Assembly of cyclin D-dependent kinase and titration of p27Kip1 regulated by mitogen-activated protein kinase kinase (MEK1)

E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex

The retinoblastoma protein and cell cycle control

The ubiquitin system

P304

2946-2957

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P31

scholarly article

P356

10.1101/GAD.1011202

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P433

22

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P478

16

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P577

2002-11-01T00:00:00Z

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11031515

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P698

12435635

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P921

phosphorylation

P932

187481

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