The pRb-related protein p130 is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCF(Skp2).
about
The retinoblastoma family of proteins and their regulatory functions in the mammalian cell division cycleCooperation of ERK and SCFSkp2 for MKP-1 destruction provides a positive feedback regulation of proliferating signalingE2F-1 has dual roles depending on the cell cyclePhosphorylation of Skp2 regulated by CDK2 and Cdc14B protects it from degradation by APC(Cdh1) in G1 phaseDeacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradationPhosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7Epstein-Barr virus latent antigen 3C can mediate the degradation of the retinoblastoma protein through an SCF cellular ubiquitin ligaseThe ETS protein MEF is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCFSkp2.B55alpha PP2A holoenzymes modulate the phosphorylation status of the retinoblastoma-related protein p107 and its activationSkp2: a novel potential therapeutic target for prostate cancerCyclin G2 is degraded through the ubiquitin-proteasome pathway and mediates the antiproliferative effect of activin receptor-like kinase 7Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancerReplication-initiator protein (UL9) of the herpes simplex virus 1 binds NFB42 and is degraded via the ubiquitin-proteasome pathwayThe association of mammalian DREAM complex and HPV16 E7 proteinsPP2A: more than a reset switch to activate pRB proteins during the cell cycle and in response to signaling cues.Network calisthenics: control of E2F dynamics in cell cycle entryPP1 and PP2A phosphatases--cooperating partners in modulating retinoblastoma protein activationThe SCF(Skp2) ubiquitin ligase complex interacts with the human replication licensing factor Cdt1 and regulates Cdt1 degradationRole of conformational heterogeneity in domain swapping and adapter function of the Cks proteinsTargeting the oncogenic E3 ligase Skp2 in prostate and breast cancer cells with a novel energy restriction-mimetic agentWogonin has multiple anti-cancer effects by regulating c-Myc/SKP2/Fbw7α and HDAC1/HDAC2 pathways and inducing apoptosis in human lung adenocarcinoma cell line A549Cul4A targets p27 for degradation and regulates proliferation, cell cycle exit, and differentiation during erythropoiesisRegulation of ischemic neuronal death by E2F4-p130 protein complexesDeregulation of F-box proteins and its consequence on cancer development, progression and metastasis.The balance between cell division and endoreplication depends on E2FC-DPB, transcription factors regulated by the ubiquitin-SCFSKP2A pathway in Arabidopsis.SKP2A, an F-box protein that regulates cell division, is degraded via the ubiquitin pathway.The Arabidopsis thaliana F-box protein FBL17 is essential for progression through the second mitosis during pollen development.Genetic replacement of cyclin D1 function in mouse development by cyclin D2.Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation.Low- and high-risk human papillomavirus E7 proteins regulate p130 differentlyIntegrated stability and activity control of the Drosophila Rbf1 retinoblastoma protein.The emerging role of the COP9 signalosome in cancer.F-box protein FBXO31 is down-regulated in gastric cancer and negatively regulated by miR-17 and miR-20a.The E7 proteins of low- and high-risk human papillomaviruses share the ability to target the pRB family member p130 for degradationThe amelioration of renal damage in Skp2-deficient mice canceled by p27 Kip1 deficiency in Skp2-/- p27-/- miceThe role of the RB tumour suppressor pathway in oxidative stress responses in the haematopoietic system.The ISG15 isopeptidase UBP43 is regulated by proteolysis via the SCFSkp2 ubiquitin ligase.Ubiquitin-dependent proteolysis in G1/S phase control and its relationship with tumor susceptibilityThe DREAM complex: master coordinator of cell cycle-dependent gene expression.Cullins and cancer.
P2860
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P2860
The pRb-related protein p130 is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCF(Skp2).
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
The pRb-related protein p130 i ...... in-ubiquitin ligase SCF(Skp2).
@ast
The pRb-related protein p130 i ...... in-ubiquitin ligase SCF(Skp2).
@en
type
label
The pRb-related protein p130 i ...... in-ubiquitin ligase SCF(Skp2).
@ast
The pRb-related protein p130 i ...... in-ubiquitin ligase SCF(Skp2).
@en
prefLabel
The pRb-related protein p130 i ...... in-ubiquitin ligase SCF(Skp2).
@ast
The pRb-related protein p130 i ...... in-ubiquitin ligase SCF(Skp2).
@en
P2860
P356
P1433
P1476
The pRb-related protein p130 i ...... in-ubiquitin ligase SCF(Skp2).
@en
P2093
Donato Tedesco
Steven I Reed
P2860
P304
P356
10.1101/GAD.1011202
P50
P577
2002-11-01T00:00:00Z