A novel growth- and cell cycle-regulated protein, ASK, activates human Cdc7-related kinase and is essential for G1/S transition in mammalian cells
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Drf1, a novel regulatory subunit for human Cdc7 kinaseA second human Dbf4/ASK-related protein, Drf1/ASKL1, is required for efficient progression of S and M phasesTranscriptional co-activator LEDGF interacts with Cdc7-activator of S-phase kinase (ASK) and stimulates its enzymatic activitySelective instability of Orc1 protein accounts for the absence of functional origin recognition complexes during the M-G(1) transition in mammalsA Xenopus Dbf4 homolog is required for Cdc7 chromatin binding and DNA replicationAzaindole-Based Inhibitors of Cdc7 Kinase: Impact of the Pre-DFG Residue, Val 195Human Cdc7-related kinase complex. In vitro phosphorylation of MCM by concerted actions of Cdks and Cdc7 and that of a criticial threonine residue of Cdc7 bY CdksBiochemical activities associated with mouse Mcm2 proteinHuman Dbf4/ASK promoter is activated through the Sp1 and MluI cell-cycle box (MCB) transcription elementsA 63-base pair DNA segment containing an Sp1 site but not a canonical E2F site can confer growth-dependent and E2F-mediated transcriptional stimulation of the human ASK gene encoding the regulatory subunit for human Cdc7-related kinaseIdentification of Mcm2 phosphorylation sites by S-phase-regulating kinasesThe potent Cdc7-Dbf4 (DDK) kinase inhibitor XL413 has limited activity in many cancer cell lines and discovery of potential new DDK inhibitor scaffoldsMutation of tumor suppressor gene Men1 acutely enhances proliferation of pancreatic islet cellsDDK dependent regulation of TOP2A at centromeres revealed by a chemical genetics approachHierarchy of S-phase-promoting factors: yeast Dbf4-Cdc7 kinase requires prior S-phase cyclin-dependent kinase activation.Cell cycle regulation of chromatin binding and nuclear localization of human Cdc7-ASK kinase complex.Distinct patterns of MCM protein binding in nuclei of S phase and rereplicating SV40-infected monkey kidney cells.A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity.Drf1-dependent kinase interacts with Claspin through a conserved protein motif.Initiation of eukaryotic DNA replication: conservative or liberal?Regulation and roles of Cdc7 kinase under replication stress.Cdc7-Drf1 is a developmentally regulated protein kinase required for the initiation of vertebrate DNA replicationA conserved domain of Schizosaccharomyces pombe dfp1(+) is uniquely required for chromosome stability following alkylation damage during S phasePhosphorylated Rad18 directs DNA polymerase η to sites of stalled replicationMiR-630 inhibits proliferation by targeting CDC7 kinase, but maintains the apoptotic balance by targeting multiple modulators in human lung cancer A549 cells.Cdc7 kinase complex: a key regulator in the initiation of DNA replication.Phosphorylation of MCM4 by Cdc7 kinase facilitates its interaction with Cdc45 on the chromatin.Characterization of a Drosophila ortholog of the Cdc7 kinase: a role for Cdc7 in endoreplication independent of Chiffon.Eukaryotic MCM proteins: beyond replication initiation.Dbf4 is direct downstream target of ataxia telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3-related (ATR) protein to regulate intra-S-phase checkpoint.Effect of dietary restriction and subsequent re-alimentation on the transcriptional profile of hepatic tissue in cattle.Hypomorphic mutation in an essential cell-cycle kinase causes growth retardation and impaired spermatogenesis.DNA replication and progression through S phase.Cdc7-dependent and -independent phosphorylation of Claspin in the induction of the DNA replication checkpointMicroRNA-29a regulates the benzo[a]pyrene dihydrodiol epoxide-induced DNA damage response through Cdc7 kinase in lung cancer cells.Combined integrin phosphoproteomic analyses and small interfering RNA--based functional screening identify key regulators for cancer cell adhesion and migration.Budding yeast Dbf4 sequences required for Cdc7 kinase activation and identification of a functional relationship between the Dbf4 and Rev1 BRCT domainsRegulation of initiation of S phase, replication checkpoint signaling, and maintenance of mitotic chromosome structures during S phase by Hsk1 kinase in the fission yeast.Tissue-Specific Gene Repositioning by Muscle Nuclear Membrane Proteins Enhances Repression of Critical Developmental Genes during Myogenesis.ATR-Chk1-APC/CCdh1-dependent stabilization of Cdc7-ASK (Dbf4) kinase is required for DNA lesion bypass under replication stress
P2860
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P2860
A novel growth- and cell cycle-regulated protein, ASK, activates human Cdc7-related kinase and is essential for G1/S transition in mammalian cells
description
1999 nî lūn-bûn
@nan
1999 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
A novel growth- and cell cycle ...... transition in mammalian cells
@ast
A novel growth- and cell cycle ...... transition in mammalian cells
@en
A novel growth- and cell cycle ...... transition in mammalian cells
@en-gb
A novel growth- and cell cycle ...... transition in mammalian cells
@nl
type
label
A novel growth- and cell cycle ...... transition in mammalian cells
@ast
A novel growth- and cell cycle ...... transition in mammalian cells
@en
A novel growth- and cell cycle ...... transition in mammalian cells
@en-gb
A novel growth- and cell cycle ...... transition in mammalian cells
@nl
prefLabel
A novel growth- and cell cycle ...... transition in mammalian cells
@ast
A novel growth- and cell cycle ...... transition in mammalian cells
@en
A novel growth- and cell cycle ...... transition in mammalian cells
@en-gb
A novel growth- and cell cycle ...... transition in mammalian cells
@nl
P2093
P2860
P3181
P356
P1476
A novel growth- and cell cycle ...... transition in mammalian cells
@en
P2093
W Seghezzi
P2860
P304
P3181
P356
10.1128/MCB.19.7.5083
P407
P577
1999-07-01T00:00:00Z