Cdc7 kinase complex: a key regulator in the initiation of DNA replication.
about
Essential role of phosphorylation of MCM2 by Cdc7/Dbf4 in the initiation of DNA replication in mammalian cellsDirect binding of DNA by tumor suppressor meninA second human Dbf4/ASK-related protein, Drf1/ASKL1, is required for efficient progression of S and M phasesTranscriptional co-activator LEDGF interacts with Cdc7-activator of S-phase kinase (ASK) and stimulates its enzymatic activityCDC7 kinase phosphorylates serine residues adjacent to acidic amino acids in the minichromosome maintenance 2 proteinA Xenopus Dbf4 homolog is required for Cdc7 chromatin binding and DNA replicationMechanism of cancer cell death induced by depletion of an essential replication regulatorApplication of a new dual localization-affinity purification tag reveals novel aspects of protein kinase biology in Aspergillus nidulansDual role of the Cdc7-regulatory protein Dbf4 during yeast meiosis.Cell cycle-dependent phosphorylation of the DNA polymerase epsilon subunit, Dpb2, by the Cdc28 cyclin-dependent protein kinase.Ordered assembly of Sld3, GINS and Cdc45 is distinctly regulated by DDK and CDK for activation of replication origins.Human Dbf4/ASK promoter is activated through the Sp1 and MluI cell-cycle box (MCB) transcription elementsCdc28-Clb5 (CDK-S) and Cdc7-Dbf4 (DDK) collaborate to initiate meiotic recombination in yeastRPA is an initiation factor for human chromosomal DNA replication.Cell cycle regulation of chromatin binding and nuclear localization of human Cdc7-ASK kinase complex.The Dbf4-Cdc7 kinase promotes S phase by alleviating an inhibitory activity in Mcm4A strategy for interaction site prediction between phospho-binding modules and their partners identified from proteomic dataFunctional cooperation between FACT and MCM is coordinated with cell cycle and differential complex formation.Drf1-dependent kinase interacts with Claspin through a conserved protein motif.Cdc7-Dbf4 phosphorylates MCM proteins via a docking site-mediated mechanism to promote S phase progressionThe Chk1-mediated S-phase checkpoint targets initiation factor Cdc45 via a Cdc25A/Cdk2-independent mechanism.Phosphorylation of MCM4 by Cdc7 kinase facilitates its interaction with Cdc45 on the chromatin.Functional analysis of the Aspergillus nidulans kinome.Hsk1 kinase is required for induction of meiotic dsDNA breaks without involving checkpoint kinases in fission yeast.Mechanism and regulation of meiotic recombination initiation.Characterization of a Drosophila ortholog of the Cdc7 kinase: a role for Cdc7 in endoreplication independent of Chiffon.Spo11 and the Formation of DNA Double-Strand Breaks in Meiosis.Chemical inactivation of cdc7 kinase in budding yeast results in a reversible arrest that allows efficient cell synchronization prior to meiotic recombinationGeminin overexpression prevents the completion of topoisomerase IIα chromosome decatenation, leading to aneuploidy in human mammary epithelial cellsDbf4 is direct downstream target of ataxia telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3-related (ATR) protein to regulate intra-S-phase checkpoint.Phosphorylation of the Synaptonemal Complex Protein Zip1 Regulates the Crossover/Noncrossover Decision during Yeast MeiosisCdc7 overexpression is an independent prognostic marker and a potential therapeutic target in colorectal cancer.A novel ring-like complex of Xenopus proteins essential for the initiation of DNA replicationDNA replication licensing and cell cycle kinetics of normal and neoplastic breast.A knockout screen for protein kinases required for the proper meiotic segregation of chromosomes in the fission yeast Schizosaccharomyces pombe.DNA replication licensing and cell cycle kinetics of oligodendroglial tumours.The level of origin firing inversely affects the rate of replication fork progression.Cell cycle regulation of DNA replication.MicroRNA-29a regulates the benzo[a]pyrene dihydrodiol epoxide-induced DNA damage response through Cdc7 kinase in lung cancer cells.Incorporation into the prereplicative complex activates the Mcm2-7 helicase for Cdc7-Dbf4 phosphorylation
P2860
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P2860
Cdc7 kinase complex: a key regulator in the initiation of DNA replication.
description
2002 nî lūn-bûn
@nan
2002 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի մարտին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Cdc7 kinase complex: a key regulator in the initiation of DNA replication.
@ast
Cdc7 kinase complex: a key regulator in the initiation of DNA replication.
@en
Cdc7 kinase complex: a key regulator in the initiation of DNA replication.
@nl
type
label
Cdc7 kinase complex: a key regulator in the initiation of DNA replication.
@ast
Cdc7 kinase complex: a key regulator in the initiation of DNA replication.
@en
Cdc7 kinase complex: a key regulator in the initiation of DNA replication.
@nl
prefLabel
Cdc7 kinase complex: a key regulator in the initiation of DNA replication.
@ast
Cdc7 kinase complex: a key regulator in the initiation of DNA replication.
@en
Cdc7 kinase complex: a key regulator in the initiation of DNA replication.
@nl
P2860
P356
P1476
Cdc7 kinase complex: a key regulator in the initiation of DNA replication.
@en
P2093
Hisao Masai
Ken-Ichi Arai
P2860
P304
P356
10.1002/JCP.10070
P577
2002-03-01T00:00:00Z