A single amino acid residue can determine the sensitivity of SERCAs to artemisinins
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Occurrence of pfatpase6 Single Nucleotide Polymorphisms Associated with Artemisinin Resistance among Field Isolates of Plasmodium falciparum in North-Eastern TanzaniaArtemisinin and a Series of Novel Endoperoxide Antimalarials Exert Early Effects on Digestive Vacuole MorphologyExpression in Yeast Links Field Polymorphisms in PfATP6 to in Vitro Artemisinin Resistance and Identifies New Inhibitor ClassesPurified E255L Mutant SERCA1a and Purified PfATP6 Are Sensitive to SERCA-type Inhibitors but Insensitive to ArtemisininsA single amino acid residue can determine the sensitivity of SERCAs to artemisininsA plausible mechanism for the antimalarial activity of artemisinin: A computational approachComparative genomics of the neglected human malaria parasite Plasmodium vivaxGenome scanning of Amazonian Plasmodium falciparum shows subtelomeric instability and clindamycin-resistant parasitesReal-time quantitative PCR with SYBR Green I detection for estimating copy numbers of nine drug resistance candidate genes in Plasmodium falciparumThe interplay between drug resistance and fitness in malaria parasitesCombination therapies for combating antimicrobial resistanceArtemisinins: their growing importance in medicineAnti-inflammatory and immunoregulatory functions of artemisinin and its derivativesGeographic structuring of the Plasmodium falciparum sarco(endo)plasmic reticulum Ca2+ ATPase (PfSERCA) gene diversityIn vitro sensitivity of Plasmodium falciparum from China-Myanmar border area to major ACT drugs and polymorphisms in potential target genesStatus of potential PfATP6 molecular markers for artemisinin resistance in SurinameGene encoding a deubiquitinating enzyme is mutated in artesunate- and chloroquine-resistant rodent malaria parasitesArtemisinin induces calcium-dependent protein secretion in the protozoan parasite Toxoplasma gondii.The binding modes and binding affinities of artemisinin derivatives with Plasmodium falciparum Ca2+-ATPase (PfATP6).Screening of traditionally used plants for in vivo antimalarial activity in mice.Experimental evolution of resistance to artemisinin combination therapy results in amplification of the mdr1 gene in a rodent malaria parasite.Plasmodium falciparum resistance to anti-malarial drugs in Papua New Guinea: evaluation of a community-based approach for the molecular monitoring of resistance.Experimental evolution, genetic analysis and genome re-sequencing reveal the mutation conferring artemisinin resistance in an isogenic lineage of malaria parasites.Molecular markers of anti-malarial drug resistance in Central, West and East African children with severe malaria.Increased tolerance to artemisinin in Plasmodium falciparum is mediated by a quiescence mechanismRole of pfmdr1 amplification and expression in induction of resistance to artemisinin derivatives in Plasmodium falciparum.Exploring the contribution of candidate genes to artemisinin resistance in Plasmodium falciparum.Frequency distribution of antimalarial drug resistance alleles among Plasmodium falciparum isolates from Gezira State, central Sudan, and Gedarif State, eastern Sudan.Different mutation patterns of Plasmodium falciparum among patients in Jimma University Hospital, Ethiopia.Transporters involved in resistance to antimalarial drugs.Emerging artemisinin resistance in the border areas of Thailand.Malaria parasites can develop stable resistance to artemisinin but lack mutations in candidate genes atp6 (encoding the sarcoplasmic and endoplasmic reticulum Ca2+ ATPase), tctp, mdr1, and cg10.Spontaneous mutations in the Plasmodium falciparum sarcoplasmic/ endoplasmic reticulum Ca2+-ATPase (PfATP6) gene among geographically widespread parasite populations unexposed to artemisinin-based combination therapies.Antimalarial screening via large-scale purification of Plasmodium falciparum Ca2+-ATPase 6 and in vitro studies.Genetic diversity and lack of artemisinin selection signature on the Plasmodium falciparum ATP6 in the Greater Mekong Subregion.The plant-based immunomodulator curcumin as a potential candidate for the development of an adjunctive therapy for cerebral malariaDiscovery, mechanisms of action and combination therapy of artemisininMolecular epidemiology of malaria in Cameroon. XXX. sequence analysis of Plasmodium falciparum ATPase 6, dihydrofolate reductase, and dihydropteroate synthase resistance markers in clinical isolates from children treated with an artesunate-sulfadoxiPfCRT-mediated drug transport in malarial parasites.Plasmodium falciparum isolates from southern Ghana exhibit polymorphisms in the SERCA-type PfATPase6 though sensitive to artesunate in vitro.
P2860
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P2860
A single amino acid residue can determine the sensitivity of SERCAs to artemisinins
description
2005 nî lūn-bûn
@nan
2005 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
A single amino acid residue can determine the sensitivity of SERCAs to artemisinins
@ast
A single amino acid residue can determine the sensitivity of SERCAs to artemisinins
@en
A single amino acid residue can determine the sensitivity of SERCAs to artemisinins
@en-gb
A single amino acid residue can determine the sensitivity of SERCAs to artemisinins
@nl
type
label
A single amino acid residue can determine the sensitivity of SERCAs to artemisinins
@ast
A single amino acid residue can determine the sensitivity of SERCAs to artemisinins
@en
A single amino acid residue can determine the sensitivity of SERCAs to artemisinins
@en-gb
A single amino acid residue can determine the sensitivity of SERCAs to artemisinins
@nl
prefLabel
A single amino acid residue can determine the sensitivity of SERCAs to artemisinins
@ast
A single amino acid residue can determine the sensitivity of SERCAs to artemisinins
@en
A single amino acid residue can determine the sensitivity of SERCAs to artemisinins
@en-gb
A single amino acid residue can determine the sensitivity of SERCAs to artemisinins
@nl
P2093
P2860
P921
P3181
P356
P1476
A single amino acid residue can determine the sensitivity of SERCAs to artemisinins
@en
P2093
Angus Cameron
Anne-Catrin Uhlemann
Anthony Lee
Felipe A Zuniga
Jorge Fischbarg
Malcolm East
Pavel Iserovich
Ursula Eckstein-Ludwig
P2860
P2888
P304
P3181
P356
10.1038/NSMB947
P407
P577
2005-06-05T00:00:00Z
P5875
P6179
1040833045