Role of pfmdr1 amplification and expression in induction of resistance to artemisinin derivatives in Plasmodium falciparum. - Wikidata - wikimedia - TriplyDB

Role of pfmdr1 amplification and expression in induction of resistance to artemisinin derivatives in Plasmodium falciparum.

Role of pfmdr1 amplification and expression in induction of resistance to artemisinin derivatives in Plasmodium falciparum.

http://www.wikidata.org/entity/Q33876651

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Recent clinical and molecular insights into emerging artemisinin resistance in Plasmodium falciparum A molecular marker of artemisinin-resistant Plasmodium falciparum malaria Falciparum malaria molecular drug resistance in the Democratic Republic of Congo: a systematic review Gene duplication as a mechanism of genomic adaptation to a changing environment PfMDR1: mechanisms of transport modulation by functional polymorphisms Identification and functional validation of the novel antimalarial resistance locus PF10_0355 in Plasmodium falciparum Functional analysis of Plasmodium vivax dihydrofolate reductase-thymidylate synthase genes through stable transformation of Plasmodium falciparum In vitro sensitivity of Plasmodium falciparum from China-Myanmar border area to major ACT drugs and polymorphisms in potential target genes PfCRT and PfMDR1 modulate interactions of artemisinin derivatives and ion channel blockers Experimental evolution of resistance to artemisinin combination therapy results in amplification of the mdr1 gene in a rodent malaria parasite.Molecular surveillance of Plasmodium falciparum resistance to artemisinin-based combination therapies in the Democratic Republic of Congo.Ex vivo activity of endoperoxide antimalarials, including artemisone and arterolane, against multidrug-resistant Plasmodium falciparum isolates from Cambodia.Altered temporal response of malaria parasites determines differential sensitivity to artemisinin Emerging artemisinin resistance in the border areas of Thailand.Artemisone uptake in Plasmodium falciparum-infected erythrocytes.Antimalarial screening via large-scale purification of Plasmodium falciparum Ca2+-ATPase 6 and in vitro studies.Genetic diversity and lack of artemisinin selection signature on the Plasmodium falciparum ATP6 in the Greater Mekong Subregion.Artesunate tolerance in transgenic Plasmodium falciparum parasites overexpressing a tryptophan-rich protein.Chemical genomics for studying parasite gene function and interaction.Artemisinin activity against Plasmodium falciparum requires hemoglobin uptake and digestion.Genomewide scan reveals amplification of mdr1 as a common denominator of resistance to mefloquine, lumefantrine, and artemisinin in Plasmodium chabaudi malaria parasites Phenotypic changes in artemisinin-resistant Plasmodium falciparum lines in vitro: evidence for decreased sensitivity to dormancy and growth inhibition.Phenotypic and genotypic analysis of in vitro-selected artemisinin-resistant progeny of Plasmodium falciparum Lack of association of the S769N mutation in Plasmodium falciparum SERCA (PfATP6) with resistance to artemisinins.Malaria drug resistance: new observations and developments.Mechanisms of in vitro resistance to dihydroartemisinin in Plasmodium falciparum.Mutation in the Plasmodium falciparum CRT protein determines the stereospecific activity of antimalarial cinchona alkaloids.A framework for assessing the risk of resistance for anti-malarials in development.Fitness of artemisinin-resistant Plasmodium falciparum in vitro.Evaluation of artemether-lumefantrine efficacy in the treatment of uncomplicated malaria and its association with pfmdr1, pfatpase6 and K13-propeller polymorphisms in Luanda, Angola Mefloquine exposure induces cell cycle delay and reveals stage-specific expression of the pfmdr1 gene.Altered drug susceptibility during host adaptation of a Plasmodium falciparum strain in a non-human primate model.Artemisinin resistance in Plasmodium falciparum: A process linked to dormancy?Artemisinin resistance in rodent malaria--mutation in the AP2 adaptor μ-chain suggests involvement of endocytosis and membrane protein trafficking.In vitro selection of Plasmodium falciparum Pfcrt and Pfmdr1 variants by artemisinin Ex vivo susceptibility of Plasmodium falciparum to antimalarial drugs in western, northern, and eastern Cambodia, 2011-2012: association with molecular markers.Increased pfmdr1 gene copy number and the decline in pfcrt and pfmdr1 resistance alleles in Ghanaian Plasmodium falciparum isolates after the change of anti-malarial drug treatment policy.Survey of Plasmodium falciparum multidrug resistance-1 and chloroquine resistance transporter alleles in Haiti.Genetic analysis in mice identifies cysteamine as a novel partner for artemisinin in the treatment of malaria.Drug-resistant malaria: molecular mechanisms and implications for public health.

P2860

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Role of pfmdr1 amplification and expression in induction of resistance to artemisinin derivatives in Plasmodium falciparum.

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2010 nî lūn-bûn

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Lucia Gerena

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Marina Chavchich

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P2860

The transcriptome of the intraerythrocytic developmental cycle of Plasmodium falciparum

A single amino acid residue can determine the sensitivity of SERCAs to artemisinins

Artemisinins target the SERCA of Plasmodium falciparum

Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum

Evidence that a point mutation in dihydrofolate reductase-thymidylate synthase confers resistance to pyrimethamine in falciparum malaria.

Human malaria parasites in continuous culture

The Plasmodium falciparum translationally controlled tumor protein homolog and its reaction with the antimalarial drug artemisinin

Regulatory hotspots in the malaria parasite genome dictate transcriptional variation

Synchronization of Plasmodium falciparum erythrocytic stages in culture

Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance

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