Dysregulation of protein modification by ISG15 results in brain cell injury.
about
Neuro-invasion by a 'Trojan Horse' strategy and vasculopathy during intrauterine flavivirus infectionPositive regulation of interferon regulatory factor 3 activation by Herc5 via ISG15 modificationUBP43 is a novel regulator of interferon signaling independent of its ISG15 isopeptidase activityProtein ISGylation modulates the JAK-STAT signaling pathwayUbp43 regulates BCR-ABL leukemogenesis via the type 1 interferon receptor signalingAlpha Interferon Induces Long-Lasting Refractoriness of JAK-STAT Signaling in the Mouse Liver through Induction of USP18/UBP43High-throughput immunoblotting. Ubiquitiin-like protein ISG15 modifies key regulators of signal transduction.HERC5 is an IFN-induced HECT-type E3 protein ligase that mediates type I IFN-induced ISGylation of protein targetsUbe1L and protein ISGylation are not essential for alpha/beta interferon signaling.Protein Interferon-Stimulated Gene 15 Conjugation Delays but Does Not Overcome Coronavirus Proliferation in a Model of Fulminant HepatitisHuman USP18 deficiency underlies type 1 interferonopathy leading to severe pseudo-TORCH syndrome.Usp18 regulates epidermal growth factor (EGF) receptor expression and cancer cell survival via microRNA-7.Isolation and sequence of an interferon-tau-inducible, pregnancy- and bovine interferon-stimulated gene product 15 (ISG15)-specific, bovine ubiquitin-activating E1-like (UBE1L) enzyme.Epstein-Barr virus independent dysregulation of UBP43 expression alters interferon-stimulated gene expression in Burkitt lymphoma.Interferon-stimulated gene 15 (ISG15) conjugates proteins in dermatomyositis muscle with perifascicular atrophy.ISG15, an interferon-stimulated ubiquitin-like protein, is not essential for STAT1 signaling and responses against vesicular stomatitis and lymphocytic choriomeningitis virus.An optimal ubiquitin-proteasome pathway in the nervous system: the role of deubiquitinating enzymes.Involvement of UBE1L in ISG15 conjugation during retinoid-induced differentiation of acute promyelocytic leukemia.The ISG15 isopeptidase UBP43 is regulated by proteolysis via the SCFSkp2 ubiquitin ligase.Interferon-stimulated genes: a complex web of host defenses.Selective inactivation of USP18 isopeptidase activity in vivo enhances ISG15 conjugation and viral resistanceSpecific and covalent targeting of conjugating and deconjugating enzymes of ubiquitin-like proteins.Altered central nervous system gene expression caused by congenitally acquired persistent infection with lymphocytic choriomeningitis virus.Balancing act: deubiquitinating enzymes in the nervous system.Ubp43 gene expression is required for normal Isg15 expression and fetal development.USP18 lack in microglia causes destructive interferonopathy of the mouse brain.Microarray analysis reveals that Type I interferon strongly increases the expression of immune-response related genes in Ubp43 (Usp18) deficient macrophages.Mice null for the deubiquitinase USP18 spontaneously develop leiomyosarcomasViral defense, carcinogenesis and ISG15: novel roles for an old ISGCharacterization of ubiquitin and ubiquitin-like-protein isopeptidase activities.Ubiquitin specific protease 18 (Usp18) is a WT1 transcriptional targetDifferential effects of Usp14 and Uch-L1 on the ubiquitin proteasome system and synaptic activity.N-ethyl-N-nitrosourea-induced mutation in ubiquitin-specific peptidase 18 causes hyperactivation of IFN-αß signaling and suppresses STAT4-induced IFN-γ production, resulting in increased susceptibility to Salmonella typhimurium.Interferon-stimulated gene 15 and the protein ISGylation system.Identification and Validation of ISG15 Target Proteins.Ubiquitin-like protein modifiers and their potential for antiviral and anti-HCV therapy.Deubiquitylases from genes to organism.Activation of endogenous type I IFN signaling contributes to persistent HCV infection.Knockdown of USP18 increases α 2a interferon signaling and induction of interferon-stimulating genes but does not increase antiviral activity in Huh7 cells.HCV innate immune responses.
P2860
Q24276687-ABC02AE8-F19E-47FF-A24F-F25C136A2DDAQ24304218-8133B8F6-5160-45B7-9AC2-92870DDFC997Q24337310-FA98138B-0ADE-4DD7-99A7-3341ED1D37B4Q24672739-34303695-B89C-4B4C-9B05-F48D62691D98Q24685070-F34C0443-10C6-4EE5-B6F2-F7A4D957A3F8Q27489129-A126DD61-434C-4F49-A339-F43498DFD212Q27863761-E6037EDB-1FC1-41E2-B3E8-F6B337DB0CD1Q27863927-DA78F024-CC08-4763-BB09-F316AE59BC5AQ28504645-04AA2A2F-F70C-4681-B166-7251CAF1042EQ30049307-D538E9D9-CF44-4E3F-A25C-D418428F33C8Q30090228-B9E07370-5C9B-4605-8A33-1BCB84E3EE54Q30425986-A6C023A2-3194-44FD-B0F2-26684C054BDAQ31114732-01894608-0362-424B-BAD0-E99A93C52F82Q33473904-FF9F8AE5-C17A-45A4-9643-E9F74F9FE10BQ33534742-B01F6817-E601-4E46-836F-C1AA21910DE9Q33925311-56E28214-947C-4292-884E-EE9CAE7A5242Q34063163-C1132033-28AD-4851-904B-E38B00320F01Q34300055-4F2374DB-0C3A-48D7-B9AA-B7E171BF5BC7Q34345166-A4A0501F-9C3E-4822-A088-42D2A077308EQ34405609-B3ED4D47-68F3-4F2E-A9A0-0F0A750EA2ADQ34458906-0F6BD84F-3635-4089-BC58-5FA4E93BC4B5Q34551647-47D8495A-6880-4902-B939-1769C28599D3Q35024355-63F1AC63-089E-4859-8643-5C007B00C9D2Q35353963-8F0EDC05-210E-4903-AA02-F9A7EE9DC24CQ35750764-0203C87B-03A5-4222-8AA4-1F990A0F3532Q35762623-F6EBE744-7F1D-4FE8-A616-2552FC4AAA53Q35793040-0C712C2D-74C2-4F48-ADE9-E001DC8800E4Q35837348-113D59D6-2934-4218-B4BB-369C413E616AQ36065915-0B00362D-8C0F-43AA-A8DE-89BF9D74CC78Q36662171-767C415E-62DC-457D-9786-DEAE4825D9FDQ37217819-CB1C11FC-DF7D-4327-A0E4-D6D127755BACQ37325929-AB7AC212-23F7-4D2D-930F-043DB8C5FC00Q37704375-87C48C39-1A18-4171-8F29-0B5D6A6FDBD6Q37824472-F48C5AD4-12F1-4666-A9C8-55EB413E5669Q37827468-8EB7123D-58A3-4992-A9C1-2EE8219A8EAAQ38115330-AE25004C-C37B-4B3C-9D04-3F2C7DE14B87Q38125278-720FEC26-E988-459E-ACE0-7A62D4DA89A5Q38210107-31BB8810-D54F-4572-91E9-3E07B5A6C79BQ38283315-55D1FD0F-252E-4DCA-AA5B-1596CB9169D5Q38613608-3F68F566-2870-48EF-B7F2-72B3D548A564
P2860
Dysregulation of protein modification by ISG15 results in brain cell injury.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
Dysregulation of protein modification by ISG15 results in brain cell injury.
@ast
Dysregulation of protein modification by ISG15 results in brain cell injury.
@en
type
label
Dysregulation of protein modification by ISG15 results in brain cell injury.
@ast
Dysregulation of protein modification by ISG15 results in brain cell injury.
@en
prefLabel
Dysregulation of protein modification by ISG15 results in brain cell injury.
@ast
Dysregulation of protein modification by ISG15 results in brain cell injury.
@en
P2093
P2860
P356
P1433
P1476
Dysregulation of protein modification by ISG15 results in brain cell injury.
@en
P2093
Christopher J Hetherington
Dong-Er Zhang
Jack C Sipe
Kenneth J Ritchie
Liming Zhou
Marie-Terese Little
Michael P Malakhov
Oxana A Malakhova
Stuart H Orkin
P2860
P304
P356
10.1101/GAD.1010202
P577
2002-09-01T00:00:00Z