Dysregulation of protein modification by ISG15 results in brain cell injury. - Wikidata - wikimedia - TriplyDB

Dysregulation of protein modification by ISG15 results in brain cell injury.

Dysregulation of protein modification by ISG15 results in brain cell injury.

http://www.wikidata.org/entity/Q35787335

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Neuro-invasion by a 'Trojan Horse' strategy and vasculopathy during intrauterine flavivirus infection Positive regulation of interferon regulatory factor 3 activation by Herc5 via ISG15 modification UBP43 is a novel regulator of interferon signaling independent of its ISG15 isopeptidase activity Protein ISGylation modulates the JAK-STAT signaling pathway Ubp43 regulates BCR-ABL leukemogenesis via the type 1 interferon receptor signaling Alpha Interferon Induces Long-Lasting Refractoriness of JAK-STAT Signaling in the Mouse Liver through Induction of USP18/UBP43 High-throughput immunoblotting. Ubiquitiin-like protein ISG15 modifies key regulators of signal transduction.HERC5 is an IFN-induced HECT-type E3 protein ligase that mediates type I IFN-induced ISGylation of protein targets Ube1L and protein ISGylation are not essential for alpha/beta interferon signaling.Protein Interferon-Stimulated Gene 15 Conjugation Delays but Does Not Overcome Coronavirus Proliferation in a Model of Fulminant Hepatitis Human USP18 deficiency underlies type 1 interferonopathy leading to severe pseudo-TORCH syndrome.Usp18 regulates epidermal growth factor (EGF) receptor expression and cancer cell survival via microRNA-7.Isolation and sequence of an interferon-tau-inducible, pregnancy- and bovine interferon-stimulated gene product 15 (ISG15)-specific, bovine ubiquitin-activating E1-like (UBE1L) enzyme.Epstein-Barr virus independent dysregulation of UBP43 expression alters interferon-stimulated gene expression in Burkitt lymphoma.Interferon-stimulated gene 15 (ISG15) conjugates proteins in dermatomyositis muscle with perifascicular atrophy.ISG15, an interferon-stimulated ubiquitin-like protein, is not essential for STAT1 signaling and responses against vesicular stomatitis and lymphocytic choriomeningitis virus.An optimal ubiquitin-proteasome pathway in the nervous system: the role of deubiquitinating enzymes.Involvement of UBE1L in ISG15 conjugation during retinoid-induced differentiation of acute promyelocytic leukemia.The ISG15 isopeptidase UBP43 is regulated by proteolysis via the SCFSkp2 ubiquitin ligase.Interferon-stimulated genes: a complex web of host defenses.Selective inactivation of USP18 isopeptidase activity in vivo enhances ISG15 conjugation and viral resistance Specific and covalent targeting of conjugating and deconjugating enzymes of ubiquitin-like proteins.Altered central nervous system gene expression caused by congenitally acquired persistent infection with lymphocytic choriomeningitis virus.Balancing act: deubiquitinating enzymes in the nervous system.Ubp43 gene expression is required for normal Isg15 expression and fetal development.USP18 lack in microglia causes destructive interferonopathy of the mouse brain.Microarray analysis reveals that Type I interferon strongly increases the expression of immune-response related genes in Ubp43 (Usp18) deficient macrophages.Mice null for the deubiquitinase USP18 spontaneously develop leiomyosarcomas Viral defense, carcinogenesis and ISG15: novel roles for an old ISG Characterization of ubiquitin and ubiquitin-like-protein isopeptidase activities.Ubiquitin specific protease 18 (Usp18) is a WT1 transcriptional target Differential effects of Usp14 and Uch-L1 on the ubiquitin proteasome system and synaptic activity.N-ethyl-N-nitrosourea-induced mutation in ubiquitin-specific peptidase 18 causes hyperactivation of IFN-αß signaling and suppresses STAT4-induced IFN-γ production, resulting in increased susceptibility to Salmonella typhimurium.Interferon-stimulated gene 15 and the protein ISGylation system.Identification and Validation of ISG15 Target Proteins.Ubiquitin-like protein modifiers and their potential for antiviral and anti-HCV therapy.Deubiquitylases from genes to organism.Activation of endogenous type I IFN signaling contributes to persistent HCV infection.Knockdown of USP18 increases α 2a interferon signaling and induction of interferon-stimulating genes but does not increase antiviral activity in Huh7 cells.HCV innate immune responses.

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Dysregulation of protein modification by ISG15 results in brain cell injury.

http://www.wikidata.org/entity/Q35787335

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2002 nî lūn-bûn

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name

Dysregulation of protein modification by ISG15 results in brain cell injury.

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Dysregulation of protein modification by ISG15 results in brain cell injury.

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type

label

Dysregulation of protein modification by ISG15 results in brain cell injury.

@ast

Dysregulation of protein modification by ISG15 results in brain cell injury.

@en

prefLabel

Dysregulation of protein modification by ISG15 results in brain cell injury.

@ast

Dysregulation of protein modification by ISG15 results in brain cell injury.

@en

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Genes & Development

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Dysregulation of protein modification by ISG15 results in brain cell injury.

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Christopher J Hetherington

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Dong-Er Zhang

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Jack C Sipe

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Kenneth J Ritchie

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Liming Zhou

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Marie-Terese Little

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Michael P Malakhov

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Oxana A Malakhova

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Stuart H Orkin

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P2860

Deubiquitinating enzymes: a new class of biological regulators

Cloning and characterization of a novel human ubiquitin-specific protease, a homologue of murine UBP43 (Usp18)

Influenza B virus NS1 protein inhibits conjugation of the interferon (IFN)-induced ubiquitin-like ISG15 protein

UBP43 (USP18) specifically removes ISG15 from conjugated proteins.

Ubiquitin-dependent protein degradation

Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome

Regulation of ubiquitin-dependent processes by deubiquitinating enzymes

A specific, nonproliferative role for E2F-5 in choroid plexus function revealed by gene targeting

The NEDD8 system is essential for cell cycle progression and morphogenetic pathway in mice

Protein regulation by monoubiquitin

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