about
P688
Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathwayAncient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling.Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNAThe N terminus of cGAS de-oligomerizes the cGAS:DNA complex and lifts the DNA size restriction of core-cGAS activity.Nonspecific DNA Binding of cGAS N Terminus Promotes cGAS Activation.Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses.Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP.PQBP1 Is a Proximal Sensor of the cGAS-Dependent Innate Response to HIV-1.cGAS surveillance of micronuclei links genome instability to innate immunity.Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay.Nuclear cGAS suppresses DNA repair and promotes tumorigenesisHuman Cytomegalovirus Protein UL31 Inhibits DNA Sensing of cGAS to Mediate Immune EvasionStructure of the Human cGAS-DNA Complex Reveals Enhanced Control of Immune SurveillancePhosphoinositide Interactions Position cGAS at the Plasma Membrane to Ensure Efficient Distinction between Self- and Viral DNA
P921
Q24306635-A47FE25D-F3FF-457F-ADA0-181B591E458FQ24338728-85953661-9ADA-4A56-B6A9-E970E6DFFCAFQ28118718-C75D3BD6-28CF-459C-85D9-578ABE29A486Q29871106-69ED0677-68D8-4912-BE05-B56D385FBFF1Q29871114-4EE83E0F-99C5-4493-8CE5-4A854C88A45EQ34362864-4D322D86-32ED-4D79-981B-6A69D89EA70CQ34374085-2CAF649A-9675-4013-809F-9310836F91C4Q35854630-033A09B9-C927-47CE-9271-52454A89E6D8Q41412907-9A42FB5C-7864-4D1E-8112-7B716F083B4CQ42362086-1D2AAF22-75AA-41AC-8E30-9FBCA352CEE8Q57793642-19358D7D-8E27-4992-A25D-CEF03AB0C646Q89222818-9E20DBE2-6AE7-4937-9EC2-1FFA92844307Q90210829-7B11C371-2E0C-4BDF-BDA6-0E4B306E366CQ92083784-15D46AC5-CC88-4252-86A4-B493E49C5A2D
P921
description
Protein in Homo sapiens
@de
mammalian protein found in Homo sapiens
@en
protein
@id
proteïne in Cyclic GMP-AMP synthase
@nl
protèin
@ace
بروتين في الإنسان العاقل
@ar
name
Cyclic GMP-AMP synthase
@en
type
label
Cyclic GMP-AMP synthase
@en
altLabel
2'3'-cGAMP synthase
@en
CGAS
@en
MB21D1
@en
Mab-21 domain containing 1
@en
cGAMP synthase
@en
cyclic GMP-AMP synthase
@en
mab-21 domain-containing protein 1
@en
protein MB21D1
@en
prefLabel
Cyclic GMP-AMP synthase
@en
P638
P680
P682
P352
P637
P279
P31
P352
P527
P637
P638
P680
P682
P702
P703
P705
ENSP00000359339
ENSP00000359342