Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay.

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cGAS/STING Pathway in Cancer: Jekyll and Hyde Story of Cancer Immune Response.The catalytic mechanism of cyclic GMP-AMP synthase (cGAS) and implications for innate immunity and inhibition.

P2860

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Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay.

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http://www.wikidata.org/entity/Q42362086

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2017 nî lūn-bûn

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2017年の論文

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2017年論文

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2017年論文

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2017年論文

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2017年論文

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2017年論文

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2017年论文

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2017年论文

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2017年论文

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name

Discovery of PF-06928215 as a ...... uorescence polarization assay.

@en

Discovery of PF-06928215 as a ...... uorescence polarization assay.

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type

Item

label

Discovery of PF-06928215 as a ...... uorescence polarization assay.

@en

Discovery of PF-06928215 as a ...... uorescence polarization assay.

@nl

prefLabel

Discovery of PF-06928215 as a ...... uorescence polarization assay.

@en

Discovery of PF-06928215 as a ...... uorescence polarization assay.

@nl

P1476

Discovery of PF-06928215 as a ...... luorescence polarization assay

@en

P2093

Amy Brault

http://www.w3.org/2001/XMLSchema#string

Ann Aulabaugh

http://www.w3.org/2001/XMLSchema#string

Betsy Pierce

http://www.w3.org/2001/XMLSchema#string

Bruce Lefker

http://www.w3.org/2001/XMLSchema#string

Dana Castro

http://www.w3.org/2001/XMLSchema#string

Daniel Schmitt

http://www.w3.org/2001/XMLSchema#string

Darren Dumlao

http://www.w3.org/2001/XMLSchema#string

David Hepworth

http://www.w3.org/2001/XMLSchema#string

David Lin

http://www.w3.org/2001/XMLSchema#string

Dikran Aivazian

http://www.w3.org/2001/XMLSchema#string

P2860

Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway

Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling.

Trex1 prevents cell-intrinsic initiation of autoimmunity

Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase

Structural mechanism of cytosolic DNA sensing by cGAS

The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop

Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA

Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 cause Aicardi-Goutières syndrome at the AGS1 locus

Molecular evolutionary and structural analysis of the cytosolic DNA sensor cGAS and STING

Structure-guided reprogramming of human cGAS dinucleotide linkage specificity.

P304

e0184843

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P31

scholarly article

P356

10.1371/JOURNAL.PONE.0184843

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P407

English

P433

http://www.w3.org/2001/XMLSchema#string

P478

http://www.w3.org/2001/XMLSchema#string

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Justin Hall

P577

2017-09-21T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

28934246

http://www.w3.org/2001/XMLSchema#string

P921

cyclic-GMP-AMP synthase activity

Cyclic GMP-AMP synthase

P932

5608272

http://www.w3.org/2001/XMLSchema#string

Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay.

about

P2860

P2860

Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay.

description

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type

label

prefLabel

P1433

P1476

P2093

P2860

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P356

P407

P433

P478

P50

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P698

P921

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P1433

P1476

P2093

P2860

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P31

P356

P407

P433

P478

P50

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P921

P932