The huntingtin interacting protein HIP1 is a clathrin and alpha-adaptin-binding protein involved in receptor-mediated endocytosis
about
Huntingtin interacting proteins are genetic modifiers of neurodegenerationHIP1 and HIP12 display differential binding to F-actin, AP2, and clathrin. Identification of a novel interaction with clathrin light chainHuntingtin-interacting protein 1-mediated neuronal cell death occurs through intrinsic apoptotic pathways and mitochondrial alterationsHIP1 and HIP1r stabilize receptor tyrosine kinases and bind 3-phosphoinositides via epsin N-terminal homology domainsHuntingtin interacting protein 1 modulates the transcriptional activity of nuclear hormone receptorsHuntingtin-interacting protein 1 (Hip1) and Hip1-related protein (Hip1R) bind the conserved sequence of clathrin light chains and thereby influence clathrin assembly in vitro and actin distribution in vivoClint: a novel clathrin-binding ENTH-domain protein at the GolgiRNAi-mediated Hip1R silencing results in stable association between the endocytic machinery and the actin assembly machinery.Crystal Structure at 2.8 Å of Huntingtin-Interacting Protein 1 (HIP1) Coiled-Coil Domain Reveals a Charged Surface Suitable for HIP1 Protein Interactor (HIPPI)Scd5p and clathrin function are important for cortical actin organization, endocytosis, and localization of sla2p in yeast.The ENTH domainHuntingtin-interacting protein 1 is overexpressed in prostate and colon cancer and is critical for cellular survivalHuntingtin-associated protein 1 interacts with hepatocyte growth factor-regulated tyrosine kinase substrate and functions in endosomal traffickingHuntingtin interacting protein 1 (HIP1) regulates clathrin assembly through direct binding to the regulatory region of the clathrin light chainDisruption of the endocytic protein HIP1 results in neurological deficits and decreased AMPA receptor traffickingHuntingtin inhibits caspase-3 activationIs Huntingtin Dispensable in the Adult Brain?Stage-specific gene expression in early differentiating oligodendrocytes.Transcriptomic responses in mouse brain exposed to chronic excess of the neurotransmitter glutamate.Recurrent distal 7q11.23 deletion including HIP1 and YWHAG identified in patients with intellectual disabilities, epilepsy, and neurobehavioral problems.Therapeutic approaches to preventing cell death in Huntington diseaseUse of a cryptic splice site for the expression of huntingtin interacting protein 1 in select normal and neoplastic tissues.Huntingtin-interacting protein 1: a Merkel cell carcinoma marker that interacts with c-Kit.blue cheese mutations define a novel, conserved gene involved in progressive neural degeneration.Clathrin light chains function in mannose phosphate receptor trafficking via regulation of actin assembly.Alterations in the Brain Transcriptome in Plasmodium Berghei ANKA Infected Mice.Multiple pathways contribute to the pathogenesis of Huntington disease.Huntingtin-interacting protein 1 phosphorylation by receptor tyrosine kinases.A large number of protein expression changes occur early in life and precede phenotype onset in a mouse model for huntington disease.Huntingtin-associated protein 1 regulates inhibitory synaptic transmission by modulating gamma-aminobutyric acid type A receptor membrane trafficking.Pathogenesis of prostate cancer and hormone refractory prostate cancer.Hip1-related mutant mice grow and develop normally but have accelerated spinal abnormalities and dwarfism in the absence of HIP1.The role of F-actin in modulating Clathrin-mediated endocytosis: Lessons from neurons in health and neuropsychiatric disorder.Unconventional functions for clathrin, ESCRTs, and other endocytic regulators in the cytoskeleton, cell cycle, nucleus, and beyond: links to human disease.Huntingtin interacting protein 1 as a histopathologic adjunct in the diagnosis of Merkel cell carcinoma.The Role of Cathepsin D in the Pathogenesis of Human Neurodegenerative Disorders.Host cell virus entry mechanisms enhance anti-JCV-antibody switch in natalizumab-treated multiple sclerosis patients.Pathogenic Huntington Alters BMP Signaling and Synaptic Growth through Local Disruptions of Endosomal Compartments.Differential electrophysiological and morphological alterations of thalamostriatal and corticostriatal projections in the R6/2 mouse model of Huntington's disease.Huntingtin associates with acidic phospholipids at the plasma membrane.
P2860
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P2860
The huntingtin interacting protein HIP1 is a clathrin and alpha-adaptin-binding protein involved in receptor-mediated endocytosis
description
2001 nî lūn-bûn
@nan
2001 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
The huntingtin interacting pro ...... receptor-mediated endocytosis
@ast
The huntingtin interacting pro ...... receptor-mediated endocytosis
@en
The huntingtin interacting pro ...... receptor-mediated endocytosis
@en-gb
The huntingtin interacting pro ...... receptor-mediated endocytosis
@nl
type
label
The huntingtin interacting pro ...... receptor-mediated endocytosis
@ast
The huntingtin interacting pro ...... receptor-mediated endocytosis
@en
The huntingtin interacting pro ...... receptor-mediated endocytosis
@en-gb
The huntingtin interacting pro ...... receptor-mediated endocytosis
@nl
prefLabel
The huntingtin interacting pro ...... receptor-mediated endocytosis
@ast
The huntingtin interacting pro ...... receptor-mediated endocytosis
@en
The huntingtin interacting pro ...... receptor-mediated endocytosis
@en-gb
The huntingtin interacting pro ...... receptor-mediated endocytosis
@nl
P2093
P921
P356
P1476
The huntingtin interacting pro ...... receptor-mediated endocytosis
@en
P2093
E E Wanker
E Nordhoff
E Scherzinger
K Sathasivam
R Hasenbank
P304
P356
10.1093/HMG/10.17.1807
P407
P50
P577
2001-08-15T00:00:00Z