Huntingtin associates with acidic phospholipids at the plasma membrane. - Wikidata - wikimedia - TriplyDB

Huntingtin associates with acidic phospholipids at the plasma membrane.

Huntingtin associates with acidic phospholipids at the plasma membrane.

http://www.wikidata.org/entity/Q40387540

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Huntingtin-interacting proteins, HIP14 and HIP14L, mediate dual functions, palmitoyl acyltransferase and Mg2+ transport Palmitoylation of huntingtin by HIP14 is essential for its trafficking and function Deletion of the triplet repeat encoding polyglutamine within the mouse Huntington's disease gene results in subtle behavioral/motor phenotypes in vivo and elevated levels of ATP with cellular senescence in vitro Scalable production in human cells and biochemical characterization of full-length normal and mutant huntingtin Generation and Characterization of Knock-in Mouse Models Expressing Versions of Huntingtin with Either an N17 or a Combined PolyQ and Proline-Rich Region Deletion.Biophysical insights into how surfaces, including lipid membranes, modulate protein aggregation related to neurodegeneration.Huntingtin coordinates the dynein-mediated dynamic positioning of endosomes and lysosomes.The Huntington disease protein accelerates breast tumour development and metastasis through ErbB2/HER2 signalling.Rescue of homeostatic regulation of striatal excitability and locomotor activity in a mouse model of Huntington's disease.Cholesterol Modifies Huntingtin Binding to, Disruption of, and Aggregation on Lipid Membranes.Protein-lipid interactions: correlation of a predictive algorithm for lipid-binding sites with three-dimensional structural data Huntingtin interacts with the cue domain of gp78 and inhibits gp78 binding to ubiquitin and p97/VCP.Resolving the paradox for protein aggregation diseases: NMR structure and dynamics of the membrane-embedded P56S-MSP causing ALS imply a common mechanism for aggregation-prone proteins to attack membranes Abnormal mitochondrial dynamics, mitochondrial loss and mutant huntingtin oligomers in Huntington's disease: implications for selective neuronal damage.Cysteine proteases bleomycin hydrolase and cathepsin Z mediate N-terminal proteolysis and toxicity of mutant huntingtin.Cysteine oxidation within N-terminal mutant huntingtin promotes oligomerization and delays clearance of soluble protein.A striatal-enriched intronic GPCR modulates huntingtin levels and toxicity Probing the Huntingtin 1-17 membrane anchor on a phospholipid bilayer by using all-atom simulations Huntington's Disease and Striatal Signaling.Mass spectrometric identification of novel lysine acetylation sites in huntingtin Mutant huntingtin, abnormal mitochondrial dynamics, defective axonal transport of mitochondria, and selective synaptic degeneration in Huntington's disease Mutant huntingtin's interaction with mitochondrial protein Drp1 impairs mitochondrial biogenesis and causes defective axonal transport and synaptic degeneration in Huntington's disease.Native mutant huntingtin in human brain: evidence for prevalence of full-length monomer The emerging role of the first 17 amino acids of huntingtin in Huntington's disease Glycolipid and ganglioside metabolism imbalances in Huntington's disease.Ca2+-dependent calmodulin binding to FcRn affects immunoglobulin G transport in the transcytotic pathway Hypothesis: Huntingtin may function in membrane association and vesicular trafficking.The interaction of polyglutamine peptides with lipid membranes is regulated by flanking sequences associated with huntingtin Acetylation within the First 17 Residues of Huntingtin Exon 1 Alters Aggregation and Lipid Binding.Mutant huntingtin and mitochondrial dysfunction.Mitochondrial structural and functional dynamics in Huntington's disease.Molecular identification of ancient and modern mammalian magnesium transporters.Proteins Containing Expanded Polyglutamine Tracts and Neurodegenerative Disease.Expression and characterization of full-length human huntingtin, an elongated HEAT repeat protein.The role of post-translational modifications of huntingtin in the pathogenesis of Huntington's disease Structure of a single-chain Fv bound to the 17 N-terminal residues of huntingtin provides insights into pathogenic amyloid formation and suppression.Huntingtin cleavage product A forms in neurons and is reduced by gamma-secretase inhibitors Mitochondrial division inhibitor 1 protects against mutant huntingtin-induced abnormal mitochondrial dynamics and neuronal damage in Huntington's disease.Multifaceted roles of tunneling nanotubes in intercellular communication.Conformational behavior and aggregation of ataxin-3 in SDS.

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Huntingtin associates with acidic phospholipids at the plasma membrane.

http://www.wikidata.org/entity/Q40387540

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2005 nî lūn-bûn

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2005年の論文

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年學術文章

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2005年學術文章

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2005年學術文章

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name

Huntingtin associates with acidic phospholipids at the plasma membrane.

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type

label

Huntingtin associates with acidic phospholipids at the plasma membrane.

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Huntingtin associates with acidic phospholipids at the plasma membrane.

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Journal of Biological Chemistry

P1476

Huntingtin associates with acidic phospholipids at the plasma membrane.

@en

P2093

Benjamin Cuiffo

http://www.w3.org/2001/XMLSchema#string

David L Scott

http://www.w3.org/2001/XMLSchema#string

Ellen Sapp

http://www.w3.org/2001/XMLSchema#string

Gerhard Isenberg

http://www.w3.org/2001/XMLSchema#string

Jennifer Yoder

http://www.w3.org/2001/XMLSchema#string

Kimberly B Kegel

http://www.w3.org/2001/XMLSchema#string

Lindsay Sobin

http://www.w3.org/2001/XMLSchema#string

Marian DiFiglia

http://www.w3.org/2001/XMLSchema#string

Neil Aronin

http://www.w3.org/2001/XMLSchema#string

Wolfgang H Goldmann

http://www.w3.org/2001/XMLSchema#string

P2860

The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs

The huntingtin interacting protein HIP1 is a clathrin and alpha-adaptin-binding protein involved in receptor-mediated endocytosis

Clathrin- and AP-2-binding sites in HIP1 uncover a general assembly role for endocytic accessory proteins

HIP1 and HIP1r stabilize receptor tyrosine kinases and bind 3-phosphoinositides via epsin N-terminal homology domains

Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons

HIP1, a human homologue of S. cerevisiae Sla2p, interacts with membrane-associated huntingtin in the brain

HIP-I: a huntingtin interacting protein isolated by the yeast two-hybrid system

Epsin 1 undergoes nucleocytosolic shuttling and its eps15 interactor NH(2)-terminal homology (ENTH) domain, structurally similar to Armadillo and HEAT repeats, interacts with the transcription factor promyelocytic leukemia Zn(2)+ finger protein (PLZ

SWISS-MODEL: An automated protein homology-modeling server

A novel all helix fold of the AP180 amino-terminal domain for phosphoinositide binding and clathrin assembly in synaptic vesicle endocytosis

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36464-36473

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scholarly article

P356

10.1074/JBC.M503672200

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P433

43

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P478

280

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Michael R. Hayden

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2005-08-05T00:00:00Z

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16085648

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