Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation
about
Repeated phosphopeptide motifs in human Claspin are phosphorylated by Chk1 and mediate Claspin functionHuman Tim/Timeless-interacting protein, Tipin, is required for efficient progression of S phase and DNA replication checkpointThe Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpointDNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free systemCharacterization of functional domains in human ClaspinClaspin promotes normal replication fork rates in human cellsThe human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacementChk1-mediated phosphorylation of FANCE is required for the Fanconi anemia/BRCA pathwayRegulation of Claspin degradation by the ubiquitin-proteosome pathway during the cell cycle and in response to ATR-dependent checkpoint activationSpy1 expression prevents normal cellular responses to DNA damage: inhibition of apoptosis and checkpoint activationCleavage of claspin by caspase-7 during apoptosis inhibits the Chk1 pathwayHuman claspin is a ring-shaped DNA-binding protein with high affinity to branched DNA structuresCell-cycle checkpoints and cancerIn my end is my beginning: control of end resection and DSBR pathway 'choice' by cyclin-dependent kinases.Network architecture of signaling from uncoupled helicase-polymerase to cell cycle checkpoints and trans-lesion DNA synthesis.Tipin-replication protein A interaction mediates Chk1 phosphorylation by ATR in response to genotoxic stress.PI 3 kinase related kinases-independent proteolysis of BRCA1 regulates Rad51 recruitment during genotoxic stress in human cells.Drf1-dependent kinase interacts with Claspin through a conserved protein motif.Roles of replication fork-interacting and Chk1-activating domains from Claspin in a DNA replication checkpoint response.Phosphatases in the cellular response to DNA damage.Prevalence and functional analysis of sequence variants in the ATR checkpoint mediator Claspin.HERC2/USP20 coordinates CHK1 activation by modulating CLASPIN stabilitySite-specific phosphorylation of a checkpoint mediator protein controls its responses to different DNA structuresTethering DNA damage checkpoint mediator proteins topoisomerase IIbeta-binding protein 1 (TopBP1) and Claspin to DNA activates ataxia-telangiectasia mutated and RAD3-related (ATR) phosphorylation of checkpoint kinase 1 (Chk1)Role for casein kinase 1 in the phosphorylation of Claspin on critical residues necessary for the activation of Chk1.Tipin is required for stalled replication forks to resume DNA replication after removal of aphidicolin in Xenopus egg extracts.Phase I Study of Single-Agent AZD1775 (MK-1775), a Wee1 Kinase Inhibitor, in Patients With Refractory Solid Tumors.BRCA1 Is Required for Maintenance of Phospho-Chk1 and G2/M Arrest during DNA Cross-Link Repair in DT40 CellsThe human Tim-Tipin complex interacts directly with DNA polymerase epsilon and stimulates its synthetic activity.Cdc7-dependent and -independent phosphorylation of Claspin in the induction of the DNA replication checkpointFANCJ at the FORK.BRCA1 promotes the ubiquitination of PCNA and recruitment of translesion polymerases in response to replication blockade.Reconstitution of human claspin-mediated phosphorylation of Chk1 by the ATR (ataxia telangiectasia-mutated and rad3-related) checkpoint kinase.The human intra-S checkpoint response to UVC-induced DNA damage.Molecular mechanisms of DNA replication checkpoint activationThe BRCA1 ubiquitin ligase and homologous recombination repair.CRL Ubiquitin Ligases and DNA Damage Response.Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress.Mrc1/Claspin: a new role for regulation of origin firing.FANCJ/BRIP1 recruitment and regulation of FANCD2 in DNA damage responses.
P2860
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P2860
Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation
description
2004 nî lūn-bûn
@nan
2004 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Human Claspin works with BRCA1 ...... ly regulate cell proliferation
@ast
Human Claspin works with BRCA1 ...... ly regulate cell proliferation
@en
Human Claspin works with BRCA1 ...... ly regulate cell proliferation
@nl
type
label
Human Claspin works with BRCA1 ...... ly regulate cell proliferation
@ast
Human Claspin works with BRCA1 ...... ly regulate cell proliferation
@en
Human Claspin works with BRCA1 ...... ly regulate cell proliferation
@nl
prefLabel
Human Claspin works with BRCA1 ...... ly regulate cell proliferation
@ast
Human Claspin works with BRCA1 ...... ly regulate cell proliferation
@en
Human Claspin works with BRCA1 ...... ly regulate cell proliferation
@nl
P2860
P3181
P356
P1476
Human Claspin works with BRCA1 ...... ly regulate cell proliferation
@en
P2093
Shiaw-Yih Lin
P2860
P304
P3181
P356
10.1073/PNAS.0401847101
P407
P577
2004-04-27T00:00:00Z