Perinuclear localization of huntingtin as a consequence of its binding to microtubules through an interaction with beta-tubulin: relevance to Huntington's disease
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Huntingtin-interacting proteins, HIP14 and HIP14L, mediate dual functions, palmitoyl acyltransferase and Mg2+ transportCharcot-Marie-Tooth disease and intracellular trafficSystems-Level G Protein-Coupled Receptor Therapy Across a Neurodegenerative Continuum by the GLP-1 Receptor SystemMisfolding of proteins with a polyglutamine expansion is facilitated by proteasomal chaperonesMutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitroHuntingtin-HAP40 complex is a novel Rab5 effector that regulates early endosome motility and is up-regulated in Huntington's disease.Mutant huntingtin impairs post-Golgi trafficking to lysosomes by delocalizing optineurin/Rab8 complex from the Golgi apparatusRegulation of endocytic trafficking of transferrin receptor by optineurin and its impairment by a glaucoma-associated mutant.Detection of alpha-rod protein repeats using a neural network and application to huntingtin.Tricyclic pyrone compounds prevent aggregation and reverse cellular phenotypes caused by expression of mutant huntingtin protein in striatal neurons.Differential hydrophobicity drives self-assembly in Huntington's disease.Dominant negative effect of polyglutamine expansion perturbs normal function of ataxin-3 in neuronal cells.Oligomeric and polymeric aggregates formed by proteins containing expanded polyglutamineHuntingtin aggregation kinetics and their pathological role in a Drosophila Huntington's disease modelHuntingtin facilitates dynein/dynactin-mediated vesicle transport.Blocking the association of HDAC4 with MAP1S accelerates autophagy clearance of mutant Huntingtin.Microtubule destabilization and nuclear entry are sequential steps leading to toxicity in Huntington's disease.Poly-glutamine expanded huntingtin dramatically alters the genome wide binding of HSF1.Cellular and molecular biology of optineurin.Compartment-Dependent Degradation of Mutant Huntingtin Accounts for Its Preferential Accumulation in Neuronal ProcessesThe Association of VDAC with Cell Viability of PC12 Model of Huntington's Disease.Huntingtin as an essential integrator of intracellular vesicular trafficking.miRNAs: Key Players in Neurodegenerative Disorders and EpilepsyBidirectional control of postsynaptic density-95 (PSD-95) clustering by Huntingtin.Small changes, big impact: posttranslational modifications and function of huntingtin in Huntington disease.The biological function of the Huntingtin protein and its relevance to Huntington's Disease pathologyTargeting Huntington's disease through histone deacetylases.Autophagy and neurodegenerative disorders.Huntington's disease: Molecular basis of pathology and status of current therapeutic approachesRecognition and characterization of Erythropoietin binding-proteins in the brain of mice.Differential electrophysiological and morphological alterations of thalamostriatal and corticostriatal projections in the R6/2 mouse model of Huntington's disease.Cdk5 phosphorylation of huntingtin reduces its cleavage by caspases: implications for mutant huntingtin toxicity.
P2860
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P2860
Perinuclear localization of huntingtin as a consequence of its binding to microtubules through an interaction with beta-tubulin: relevance to Huntington's disease
description
2002 nî lūn-bûn
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2002 թուականի Մարտին հրատարակուած գիտական յօդուած
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2002 թվականի մարտին հրատարակված գիտական հոդված
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2002年の論文
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2002年論文
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2002年論文
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2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
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2002年论文
@wuu
name
Perinuclear localization of hu ...... evance to Huntington's disease
@ast
Perinuclear localization of hu ...... evance to Huntington's disease
@en
Perinuclear localization of hu ...... evance to Huntington's disease
@en-gb
Perinuclear localization of hu ...... evance to Huntington's disease
@nl
type
label
Perinuclear localization of hu ...... evance to Huntington's disease
@ast
Perinuclear localization of hu ...... evance to Huntington's disease
@en
Perinuclear localization of hu ...... evance to Huntington's disease
@en-gb
Perinuclear localization of hu ...... evance to Huntington's disease
@nl
prefLabel
Perinuclear localization of hu ...... evance to Huntington's disease
@ast
Perinuclear localization of hu ...... evance to Huntington's disease
@en
Perinuclear localization of hu ...... evance to Huntington's disease
@en-gb
Perinuclear localization of hu ...... evance to Huntington's disease
@nl
P921
P3181
P1476
Perinuclear localization of hu ...... evance to Huntington's disease
@en
P2093
Guylaine Hoffner
P304
P3181
P407
P577
2002-03-01T00:00:00Z