Regulation of endocytic trafficking of transferrin receptor by optineurin and its impairment by a glaucoma-associated mutant. - Wikidata - wikimedia - TriplyDB

Regulation of endocytic trafficking of transferrin receptor by optineurin and its impairment by a glaucoma-associated mutant.

Regulation of endocytic trafficking of transferrin receptor by optineurin and its impairment by a glaucoma-associated mutant.

http://www.wikidata.org/entity/Q30493294

about

Oligomerization of optineurin and its oxidative stress- or E50K mutation-driven covalent cross-linking: possible relationship with glaucoma pathology Syntaxin 17 cycles between the ER and ERGIC and is required to maintain the architecture of ERGIC and Golgi Molecular motor proteins and amyotrophic lateral sclerosis Functional analysis of optineurin and some of its disease-associated mutants Loss of optineurin in vivo results in elevated cell death and alters axonal trafficking dynamics A Glaucoma-Associated Variant of Optineurin, M98K, Activates Tbk1 to Enhance Autophagosome Formation and Retinal Cell Death Dependent on Ser177 Phosphorylation of Optineurin M98K-OPTN induces transferrin receptor degradation and RAB12-mediated autophagic death in retinal ganglion cells Impairment of protein trafficking upon overexpression and mutation of optineurin.Optineurin is required for CYLD-dependent inhibition of TNFα-induced NF-κB activation.E50K-OPTN-induced retinal cell death involves the Rab GTPase-activating protein, TBC1D17 mediated block in autophagy.Rab GTPases as regulators of endocytosis, targets of disease and therapeutic opportunities.Induction of autophagy in rats upon overexpression of wild-type and mutant optineurin gene.Mutations in the ubiquitin-binding domain of OPTN/optineurin interfere with autophagy-mediated degradation of misfolded proteins by a dominant-negative mechanism.Cellular and molecular biology of optineurin.Optineurin insufficiency impairs IRF3 but not NF-κB activation in immune cells.Effects of mutations and deletions in the human optineurin gene.Toward an integrative view of Optineurin functions.Diverse mechanisms regulate the surface expression of immunotherapeutic target ctla-4.Interaction between optineurin and Rab1a regulates autophagosome formation in neuroblastoma cells.Vitamin E and Phosphoinositides Regulate the Intracellular Localization of the Hepatic α-Tocopherol Transfer Protein.Rab8 binding to immune cell-specific adaptor LAX facilitates formation of trans-Golgi network-proximal CTLA-4 vesicles for surface expression.A yeast model of optineurin proteinopathy reveals a unique aggregation pattern associated with cellular toxicity.Major review: Molecular genetics of primary open-angle glaucoma.Yeast genetic interaction screen of human genes associated with amyotrophic lateral sclerosis: identification of MAP2K5 kinase as a potential drug target Enhanced optineurin E50K-TBK1 interaction evokes protein insolubility and initiates familial primary open-angle glaucoma.Evidence of a link between ubiquilin 2 and optineurin in amyotrophic lateral sclerosis.Optineurin promotes autophagosome formation by recruiting the autophagy-related Atg12-5-16L1 complex to phagophores containing the Wipi2 protein.Structural insights into the ubiquitin recognition by OPTN (optineurin) and its regulation by TBK1-mediated phosphorylation.Nitrogen and phosphorus co-doped graphene quantum dots: synthesis from adenosine triphosphate, optical properties, and cellular imaging.Defects in optineurin- and myosin VI-mediated cellular trafficking in amyotrophic lateral sclerosis.LRRK2 mediated Rab8a phosphorylation promotes lipid storage.Optineurin: A Coordinator of Membrane-Associated Cargo Trafficking and Autophagy.Research progress on human genes involved in the pathogenesis of glaucoma (Review).Dysfunction of Optineurin in Amyotrophic Lateral Sclerosis and Glaucoma.Altered Functions and Interactions of Glaucoma-Associated Mutants of Optineurin.

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Regulation of endocytic trafficking of transferrin receptor by optineurin and its impairment by a glaucoma-associated mutant.

http://www.wikidata.org/entity/Q30493294

description

2010 nî lūn-bûn

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2010 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2010 թվականի հունվարին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Regulation of endocytic traffi ...... a glaucoma-associated mutant.

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Regulation of endocytic traffi ...... a glaucoma-associated mutant.

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type

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Regulation of endocytic traffi ...... a glaucoma-associated mutant.

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Regulation of endocytic traffi ...... a glaucoma-associated mutant.

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prefLabel

Regulation of endocytic traffi ...... a glaucoma-associated mutant.

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Regulation of endocytic traffi ...... a glaucoma-associated mutant.

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Regulation of endocytic traffi ...... a glaucoma-associated mutant.

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P2093

Ananthamurthy Nagabhushana

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Dorairajan Balasubramanian

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Madhavi L Chalasani

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Nandini Rangaraj

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Nishant Jain

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Vegesna Radha

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P2860

Perinuclear localization of huntingtin as a consequence of its binding to microtubules through an interaction with beta-tubulin: relevance to Huntington's disease

Optineurin links myosin VI to the Golgi complex and is involved in Golgi organization and exocytosis

Regulation of p73 by Hck through kinase-dependent and independent mechanisms

Evidence for a role of transmembrane protein p25 in localization of protein tyrosine phosphatase TC48 to the ER

Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons

Enhanced binding of TBK1 by an optineurin mutant that causes a familial form of primary open angle glaucoma

Optineurin negatively regulates TNFalpha- induced NF-kappaB activation by competing with NEMO for ubiquitinated RIP

Rab11 is required for trans-golgi network-to-plasma membrane transport and a preferential target for GDP dissociation inhibitor

Rab8, a small GTPase involved in vesicular traffic between the TGN and the basolateral plasma membrane

Internalization and processing of transferrin and the transferrin receptor in human carcinoma A431 cells

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4

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scholarly article

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10.1186/1471-2121-11-4

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11

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Ghanshyam Swarup

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2010-01-19T00:00:00Z

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41087747

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1042918142

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20085643

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2826298

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