Human mesotrypsin is a unique digestive protease specialized for the degradation of trypsin inhibitors
about
Structural basis for accelerated cleavage of bovine pancreatic trypsin inhibitor (BPTI) by human mesotrypsinFunctional and Structural Roles of the Cys14–Cys38 Disulfide of Bovine Pancreatic Trypsin InhibitorDeterminants of Affinity and Proteolytic Stability in Interactions of Kunitz Family Protease Inhibitors with MesotrypsinThe P 2 ′ residue is a key determinant of mesotrypsin specificity: engineering a high-affinity inhibitor with anticancer activityPresence versus absence of hydrogen bond donor Tyr-39 influences interactions of cationic trypsin and mesotrypsin with protein protease inhibitorsSerine proteases, serine protease inhibitors, and protease-activated receptors: roles in synaptic function and behaviorSequence and conformational specificity in substrate recognition: several human Kunitz protease inhibitor domains are specific substrates of mesotrypsin.Mesotrypsin Has Evolved Four Unique Residues to Cleave Trypsin Inhibitors as SubstratesAn Acrobatic Substrate Metamorphosis Reveals a Requirement for Substrate Conformational Dynamics in Trypsin Proteolysis.Identification of novel vascular markers through gene expression profiling of tumor-derived endothelium.Human mesotrypsin exhibits restricted S1' subsite specificity with a strong preference for small polar side chainsThe amyloid precursor protein/protease nexin 2 Kunitz inhibitor domain is a highly specific substrate of mesotrypsin.Small molecule inhibitors of mesotrypsin from a structure-based docking screen.Identification of C16orf74 as a marker of progression in primary non-muscle invasive bladder cancer.Proteolytic activation of the human epithelial sodium channel by trypsin IV and trypsin I involves distinct cleavage sites.A major role for proteolytic activity and proteinase-activated receptor-2 in the pathogenesis of infectious colitis.Complete analysis of the human mesotrypsinogen gene (PRSS3) in patients with chronic pancreatitis.Serine proteases and protease-activated receptor 2 mediate the proinflammatory and algesic actions of diverse stimulants.Mesotrypsin promotes malignant growth of breast cancer cells through shedding of CD109Molecular basis for the resistance of an insect chymotrypsin to a potato type II proteinase inhibitorTransient receptor potential ion channels V4 and A1 contribute to pancreatitis pain in miceAutoantibodies against the exocrine pancreas in autoimmune pancreatitis: gene and protein expression profiling and immunoassays identify pancreatic enzymes as a major target of the inflammatory process.Autocrine extra-pancreatic trypsin 3 secretion promotes cell proliferation and survival in esophageal adenocarcinomaFinding off-targets, biological pathways, and target diseases for chymase inhibitors via structure-based systems biology approach.Association of cathepsin B gene polymorphisms with tropical calcific pancreatitisMesotrypsin Signature Mutation in a Chymotrypsin C (CTRC) Variant Associated with Chronic Pancreatitis.Combinatorial protein engineering of proteolytically resistant mesotrypsin inhibitors as candidates for cancer therapyHuman mesotrypsin defies natural trypsin inhibitors: from passive resistance to active destruction.Biochemistry and clinical role of trypsinogens and pancreatic secretory trypsin inhibitor.PRSS3/mesotrypsin is a therapeutic target for metastatic prostate cancerDifferences in the degree of cerulein-induced chronic pancreatitis in C57BL/6 mouse substrains lead to new insights in identification of potential risk factors in the development of chronic pancreatitis.Serine proteases mediate inflammatory pain in acute pancreatitis.Biochemical and structural insights into mesotrypsin: an unusual human trypsin.Global patterns of apparent copy number variation in birds revealed by cross-species comparative genomic hybridization.Expression of human cationic trypsinogen with an authentic N terminus using intein-mediated splicing in aminopeptidase P deficient Escherichia coli.Complex Formation of Human Proelastases with Procarboxypeptidases A1 and A2.Mass spectrometric detection of tyrosine sulfation in human pancreatic trypsinogens, but not in tumor-associated trypsinogen.Activity of recombinant trypsin isoforms on human proteinase-activated receptors (PAR): mesotrypsin cannot activate epithelial PAR-1, -2, but weakly activates brain PAR-1.Human pancreatitis and the role of cathepsin B.Proteolytic activation of human pancreatitis-associated protein is required for peptidoglycan binding and bacterial aggregation.
P2860
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P2860
Human mesotrypsin is a unique digestive protease specialized for the degradation of trypsin inhibitors
description
2003 nî lūn-bûn
@nan
2003 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Human mesotrypsin is a unique ...... radation of trypsin inhibitors
@ast
Human mesotrypsin is a unique ...... radation of trypsin inhibitors
@en
Human mesotrypsin is a unique ...... radation of trypsin inhibitors
@en-gb
Human mesotrypsin is a unique ...... radation of trypsin inhibitors
@nl
type
label
Human mesotrypsin is a unique ...... radation of trypsin inhibitors
@ast
Human mesotrypsin is a unique ...... radation of trypsin inhibitors
@en
Human mesotrypsin is a unique ...... radation of trypsin inhibitors
@en-gb
Human mesotrypsin is a unique ...... radation of trypsin inhibitors
@nl
prefLabel
Human mesotrypsin is a unique ...... radation of trypsin inhibitors
@ast
Human mesotrypsin is a unique ...... radation of trypsin inhibitors
@en
Human mesotrypsin is a unique ...... radation of trypsin inhibitors
@en-gb
Human mesotrypsin is a unique ...... radation of trypsin inhibitors
@nl
P2093
P2860
P921
P356
P1476
Human mesotrypsin is a unique ...... radation of trypsin inhibitors
@en
P2093
Miklos Sahin-Tóth
Richárd Szmola
Zoltán Kukor
P2860
P304
48580-48589
P356
10.1074/JBC.M310301200
P407
P577
2003-09-24T00:00:00Z