Leaky RyR2 trigger ventricular arrhythmias in Duchenne muscular dystrophy
about
Hierarchical accumulation of RyR post-translational modifications drives disease progression in dystrophic cardiomyopathyAbsence of triadin, a protein of the calcium release complex, is responsible for cardiac arrhythmia with sudden death in humanDysfunctional ryanodine receptors in the heart: new insights into complex cardiovascular diseasesS-nitrosothiols and the S-nitrosoproteome of the cardiovascular systemMechanisms of altered Ca²⁺ handling in heart failureDetyrosinated microtubules modulate mechanotransduction in heart and skeletal muscleRyanodine receptor leak mediated by caspase-8 activation leads to left ventricular injury after myocardial ischemia-reperfusionX-ROS signalling is enhanced and graded by cyclic cardiomyocyte stretch.Calcium release channel RyR2 regulates insulin release and glucose homeostasisRole of RyR2 phosphorylation in heart failure and arrhythmias: Controversies around ryanodine receptor phosphorylation in cardiac disease.Decreased inward rectifier potassium current IK1 in dystrophin-deficient ventricular cardiomyocytes.Dystrophic Cardiomyopathy-Potential Role of Calcium in Pathogenesis, Treatment and Novel TherapiesRyanodine receptor channelopathies.Blunted cardiac beta-adrenergic response as an early indication of cardiac dysfunction in Duchenne muscular dystrophy.Genetic inhibition of PKA phosphorylation of RyR2 prevents dystrophic cardiomyopathy.SERCA2a gene therapy can improve symptomatic heart failure in δ-sarcoglycan-deficient animals.Oxygen-coupled redox regulation of the skeletal muscle ryanodine receptor-Ca2+ release channel by NADPH oxidase 4NADPH oxidase-2 inhibition restores contractility and intracellular calcium handling and reduces arrhythmogenicity in dystrophic cardiomyopathy.The ryanodine receptor in cardiac physiology and disease.Stabilization of the skeletal muscle ryanodine receptor ion channel-FKBP12 complex by the 1,4-benzothiazepine derivative S107Mitigation of muscular dystrophy in mice by SERCA overexpression in skeletal muscle.Mass spectrometric analysis and mutagenesis predict involvement of multiple cysteines in redox regulation of the skeletal muscle ryanodine receptor ion channel complex.Regulation of Ryanodine Receptor Ion Channels Through Posttranslational Modifications.SERCA2a gene transfer improves electrocardiographic performance in aged mdx miceRegulation of the calpain and ubiquitin-proteasome systems in a canine model of muscular dystrophy.Triadopathies: an emerging class of skeletal muscle diseases.Dynamic denitrosylation via S-nitrosoglutathione reductase regulates cardiovascular function.Crystal structures of ryanodine receptor SPRY1 and tandem-repeat domains reveal a critical FKBP12 binding determinant.Porcine models of muscular dystrophyIn Vivo Cannulation Methods for Cardiomyocytes Isolation from Heart Disease Models.Nitric Oxide Synthase 1 Modulates Basal and β-Adrenergic-Stimulated Contractility by Rapid and Reversible Redox-Dependent S-Nitrosylation of the HeartReactive oxygen species-targeted therapeutic interventions for atrial fibrillation.Pivotal role of miR-448 in the development of ROS-induced cardiomyopathy.ACE inhibition prevents diastolic Ca2+ overload and loss of myofilament Ca2+ sensitivity after myocardial infarction.Nanospan, an alternatively spliced isoform of sarcospan, localizes to the sarcoplasmic reticulum in skeletal muscle and is absent in limb girdle muscular dystrophy 2F.Crosstalk between RyR2 oxidation and phosphorylation contributes to cardiac dysfunction in mice with Duchenne muscular dystrophy.Calcium cycling proteins and heart failure: mechanisms and therapeuticsElementary calcium release events from the sarcoplasmic reticulum in the heart.Inhibition of CaMKII phosphorylation of RyR2 prevents inducible ventricular arrhythmias in mice with Duchenne muscular dystrophy.Cardiac phenotype of Duchenne Muscular Dystrophy: insights from cellular studies
P2860
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P2860
Leaky RyR2 trigger ventricular arrhythmias in Duchenne muscular dystrophy
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Leaky RyR2 trigger ventricular arrhythmias in Duchenne muscular dystrophy
@ast
Leaky RyR2 trigger ventricular arrhythmias in Duchenne muscular dystrophy
@en
Leaky RyR2 trigger ventricular arrhythmias in Duchenne muscular dystrophy
@en-gb
Leaky RyR2 trigger ventricular arrhythmias in Duchenne muscular dystrophy
@nl
type
label
Leaky RyR2 trigger ventricular arrhythmias in Duchenne muscular dystrophy
@ast
Leaky RyR2 trigger ventricular arrhythmias in Duchenne muscular dystrophy
@en
Leaky RyR2 trigger ventricular arrhythmias in Duchenne muscular dystrophy
@en-gb
Leaky RyR2 trigger ventricular arrhythmias in Duchenne muscular dystrophy
@nl
prefLabel
Leaky RyR2 trigger ventricular arrhythmias in Duchenne muscular dystrophy
@ast
Leaky RyR2 trigger ventricular arrhythmias in Duchenne muscular dystrophy
@en
Leaky RyR2 trigger ventricular arrhythmias in Duchenne muscular dystrophy
@en-gb
Leaky RyR2 trigger ventricular arrhythmias in Duchenne muscular dystrophy
@nl
P2093
P2860
P921
P3181
P356
P1476
Leaky RyR2 trigger ventricular arrhythmias in Duchenne muscular dystrophy
@en
P2093
Andrew R Marks
Jérémy Fauconnier
Jérôme Thireau
Stefan Matecki
Steven Reiken
Sylvain Richard
P2860
P304
P3181
P356
10.1073/PNAS.0908540107
P407
P577
2010-01-26T00:00:00Z