Enhancing calstabin binding to ryanodine receptors improves cardiac and skeletal muscle function in heart failure.
about
Leaky RyR2 trigger ventricular arrhythmias in Duchenne muscular dystrophyA mutation in the human phospholamban gene, deleting arginine 14, results in lethal, hereditary cardiomyopathy.Hypernitrosylated ryanodine receptor calcium release channels are leaky in dystrophic muscleDysfunctional ryanodine receptors in the heart: new insights into complex cardiovascular diseasesPhosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmiasAbnormal calcium cycling and cardiac arrhythmias associated with the human Ser96Ala genetic variant of histidine-rich calcium-binding proteinK201 improves aspects of the contractile performance of human failing myocardium via reduction in Ca2+ leak from the sarcoplasmic reticulumRemodeling of ryanodine receptor complex causes "leaky" channels: a molecular mechanism for decreased exercise capacityCrystal structure and conformational flexibility of the unligated FK506-binding protein FKBP12.6Review of RyR1 pathway and associated pathomechanismsAnalysis of calstabin2 (FKBP12.6)-ryanodine receptor interactions: rescue of heart failure by calstabin2 in miceRole of leaky neuronal ryanodine receptors in stress-induced cognitive dysfunctionEffect of Calstabin1 depletion on calcium transients and energy utilization in muscle fibers and treatment opportunities with RyR1 stabilizersUpregulation of the CaV 1.1-ryanodine receptor complex in a rat model of critical illness myopathyCombined insulin treatment and intense exercise training improved basal cardiac function and Ca(2+)-cycling proteins expression in type 1 diabetic ratsStabilization of cardiac ryanodine receptor prevents intracellular calcium leak and arrhythmiasLeaky Ca2+ release channel/ryanodine receptor 2 causes seizures and sudden cardiac death in mice.Dysregulated sarcoplasmic reticulum calcium release: potential pharmacological target in cardiac disease.Role of RyR2 phosphorylation in heart failure and arrhythmias: protein kinase A-mediated hyperphosphorylation of the ryanodine receptor at serine 2808 does not alter cardiac contractility or cause heart failure and arrhythmiasArrhythmogenic right ventricular cardiomyopathy in Boxer dogs is associated with calstabin2 deficiency.FKBP12 activates the cardiac ryanodine receptor Ca2+-release channel and is antagonised by FKBP12.6.Ryanodine receptor/calcium release channel PKA phosphorylation: a critical mediator of heart failure progression.CGP-37157 inhibits the sarcoplasmic reticulum Ca²+ ATPase and activates ryanodine receptor channels in striated muscle.The ryanodine receptor in cardiac physiology and disease.Profile of Andrew R. Marks.Ryanodine receptors as pharmacological targets for heart disease.Diaphragm dysfunction caused by sphingomyelinase requires the p47(phox) subunit of NADPH oxidase.Calcium and arrhythmogenesis.Modifications of skeletal muscle ryanodine receptor type 1 and exercise intolerance in heart failure.Designing calcium release channel inhibitors with enhanced electron donor properties: stabilizing the closed state of ryanodine receptor type 1.Targeting cardiomyocyte Ca2+ homeostasis in heart failure.A novel human R25C-phospholamban mutation is associated with super-inhibition of calcium cycling and ventricular arrhythmiaBlockage of the Ryanodine Receptor via Azumolene Does Not Prevent Mechanical Ventilation-Induced Diaphragm Atrophy.The effect of K201 on isolated working rabbit heart mechanical function during pharmacologically induced Ca2+ overload.JTV519 (K201) reduces sarcoplasmic reticulum Ca²⁺ leak and improves diastolic function in vitro in murine and human non-failing myocardiumStressed out: the skeletal muscle ryanodine receptor as a target of stressCalcium cycling proteins and heart failure: mechanisms and therapeuticsAcute beta-adrenergic overload produces myocyte damage through calcium leakage from the ryanodine receptor 2 but spares cardiac stem cells.Calstabin 2: An important regulator for learning and memory in mice.Arrhythmogenic ion-channel remodeling in the heart: heart failure, myocardial infarction, and atrial fibrillation.
P2860
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P2860
Enhancing calstabin binding to ryanodine receptors improves cardiac and skeletal muscle function in heart failure.
description
2005 nî lūn-bûn
@nan
2005 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Enhancing calstabin binding to ...... scle function in heart failure
@nl
Enhancing calstabin binding to ...... cle function in heart failure.
@ast
Enhancing calstabin binding to ...... cle function in heart failure.
@en
Enhancing calstabin binding to ...... cle function in heart failure.
@en-gb
type
label
Enhancing calstabin binding to ...... scle function in heart failure
@nl
Enhancing calstabin binding to ...... cle function in heart failure.
@ast
Enhancing calstabin binding to ...... cle function in heart failure.
@en
Enhancing calstabin binding to ...... cle function in heart failure.
@en-gb
prefLabel
Enhancing calstabin binding to ...... scle function in heart failure
@nl
Enhancing calstabin binding to ...... cle function in heart failure.
@ast
Enhancing calstabin binding to ...... cle function in heart failure.
@en
Enhancing calstabin binding to ...... cle function in heart failure.
@en-gb
P2093
P2860
P356
P1476
Enhancing calstabin binding to ...... cle function in heart failure.
@en
P2093
Andrew R Marks
Donald W Landry
Leon J de Windt
Raymond Morales
Roel van der Nagel
Shi-Xiang Deng
Stephan E Lehnart
Steven Reiken
Zhenzhuang Cheng
P2860
P304
P356
10.1073/PNAS.0500353102
P407
P577
2005-06-22T00:00:00Z