PIKfyve controls fluid phase endocytosis but not recycling/degradation of endocytosed receptors or sorting of procathepsin D by regulating multivesicular body morphogenesis
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The Rab5 effector Rabankyrin-5 regulates and coordinates different endocytic mechanismsThe phosphoinositide kinase PIKfyve mediates epidermal growth factor receptor trafficking to the nucleusThe mammalian phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) regulates endosome-to-TGN retrograde transport.The phosphoinositide-3-phosphatase MTMR2 associates with MTMR13, a membrane-associated pseudophosphatase also mutated in type 4B Charcot-Marie-Tooth diseaseCore protein machinery for mammalian phosphatidylinositol 3,5-bisphosphate synthesis and turnover that regulates the progression of endosomal transport. Novel Sac phosphatase joins the ArPIKfyve-PIKfyve complexKinesin adapter JLP links PIKfyve to microtubule-based endosome-to-trans-Golgi network traffic of furinMutations in PIP5K3 are associated with François-Neetens mouchetée fleck corneal dystrophyThe phosphoinositide kinase PIKfyve/Fab1p regulates terminal lysosome maturation in Caenorhabditis elegansA mammalian ortholog of Saccharomyces cerevisiae Vac14 that associates with and up-regulates PIKfyve phosphoinositide 5-kinase activityThe phosphoinositide kinase PIKfyve is vital in early embryonic development: preimplantation lethality of PIKfyve-/- embryos but normality of PIKfyve+/- micePIKfyve-ArPIKfyve-Sac3 core complex: contact sites and their consequence for Sac3 phosphatase activity and endocytic membrane homeostasisA selective PIKfyve inhibitor blocks PtdIns(3,5)P(2) production and disrupts endomembrane transport and retroviral budding.PIKfyve: Partners, significance, debates and paradoxesArPIKfyve-PIKfyve interaction and role in insulin-regulated GLUT4 translocation and glucose transport in 3T3-L1 adipocytesArPIKfyve homomeric and heteromeric interactions scaffold PIKfyve and Sac3 in a complex to promote PIKfyve activity and functionalityFab1 phosphatidylinositol 3-phosphate 5-kinase controls trafficking but not silencing of endocytosed receptorsLoss of Vac14, a regulator of the signaling lipid phosphatidylinositol 3,5-bisphosphate, results in neurodegeneration in mice.Recycling Endosomes and Viral InfectionPhosphatidylinositol 3,5-bisphosphate: low abundance, high significanceEndosome maturationPhosphoinositides: tiny lipids with giant impact on cell regulationThe Fab1/PIKfyve phosphoinositide phosphate kinase is not necessary to maintain the pH of lysosomes and of the yeast vacuole.A kinome RNAi screen identified AMPK as promoting poxvirus entry through the control of actin dynamicsInhibition of PIKfyve by YM-201636 dysregulates autophagy and leads to apoptosis-independent neuronal cell deathActive PIKfyve associates with and promotes the membrane attachment of the late endosome-to-trans-Golgi network transport factor Rab9 effector p40Localized PtdIns 3,5-P2 synthesis to regulate early endosome dynamics and fusionIdentification of a novel SBF2 frameshift mutation in charcot-marie-tooth disease type 4B2 using whole-exome sequencing.Neuronal expression of Fig4 is both necessary and sufficient to prevent spongiform neurodegeneration.Host PI(3,5)P2 activity is required for Plasmodium berghei growth during liver stage infection.Characterization of PXK as a protein involved in epidermal growth factor receptor trafficking.Miz1 is required to maintain autophagic flux.Distinct pathogenic processes between Fig4-deficient motor and sensory neurons.Acquisition of unprecedented phosphatidylinositol 3,5-bisphosphate rise in hyperosmotically stressed 3T3-L1 adipocytes, mediated by ArPIKfyve-PIKfyve pathway.Visualization of cellular phosphoinositide pools with GFP-fused protein-domainsLipid kinases are essential for apicoplast homeostasis in Toxoplasma gondiiReduced Intracellular Drug Accumulation in Drug-Resistant Leukemia Cells is Not Only Solely Due to MDR-Mediated Efflux but also to Decreased UptakeClass III PI 3-kinase is the main source of PtdIns3P substrate and membrane recruitment signal for PIKfyve constitutive function in podocyte endomembrane homeostasisPtdIns5P: news and views of its appearance, disappearance and deeds.The nuclear epidermal growth factor receptor signaling network and its role in cancer.Modulation of synaptic function by VAC14, a protein that regulates the phosphoinositides PI(3,5)P₂ and PI(5)P
P2860
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P2860
PIKfyve controls fluid phase endocytosis but not recycling/degradation of endocytosed receptors or sorting of procathepsin D by regulating multivesicular body morphogenesis
description
2003 nî lūn-bûn
@nan
2003 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
PIKfyve controls fluid phase e ...... tivesicular body morphogenesis
@ast
PIKfyve controls fluid phase e ...... tivesicular body morphogenesis
@en
PIKfyve controls fluid phase e ...... tivesicular body morphogenesis
@en-gb
PIKfyve controls fluid phase e ...... tivesicular body morphogenesis
@nl
type
label
PIKfyve controls fluid phase e ...... tivesicular body morphogenesis
@ast
PIKfyve controls fluid phase e ...... tivesicular body morphogenesis
@en
PIKfyve controls fluid phase e ...... tivesicular body morphogenesis
@en-gb
PIKfyve controls fluid phase e ...... tivesicular body morphogenesis
@nl
prefLabel
PIKfyve controls fluid phase e ...... tivesicular body morphogenesis
@ast
PIKfyve controls fluid phase e ...... tivesicular body morphogenesis
@en
PIKfyve controls fluid phase e ...... tivesicular body morphogenesis
@en-gb
PIKfyve controls fluid phase e ...... tivesicular body morphogenesis
@nl
P2093
P2860
P921
P356
P1476
PIKfyve controls fluid phase e ...... tivesicular body morphogenesis
@en
P2093
Diego Sbrissa
Jean-Louis Carpentier
Michelangelo Foti
Ognian C Ikonomov
P2860
P304
P356
10.1091/MBC.E03-04-0222
P407
P577
2003-11-01T00:00:00Z