PIKfyve, a mammalian ortholog of yeast Fab1p lipid kinase, synthesizes 5-phosphoinositides. Effect of insulin
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The phosphoinositide kinase PIKfyve mediates epidermal growth factor receptor trafficking to the nucleusPIKfyve controls fluid phase endocytosis but not recycling/degradation of endocytosed receptors or sorting of procathepsin D by regulating multivesicular body morphogenesisThe mammalian phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) regulates endosome-to-TGN retrograde transport.The phosphoinositide-3-phosphatase MTMR2 associates with MTMR13, a membrane-associated pseudophosphatase also mutated in type 4B Charcot-Marie-Tooth diseaseCore protein machinery for mammalian phosphatidylinositol 3,5-bisphosphate synthesis and turnover that regulates the progression of endosomal transport. Novel Sac phosphatase joins the ArPIKfyve-PIKfyve complexPI(5)P regulates autophagosome biogenesisPtdIns-specific MPR pathway association of a novel WD40 repeat protein, WIPI49Kinesin adapter JLP links PIKfyve to microtubule-based endosome-to-trans-Golgi network traffic of furinThe LIM protein Ajuba regulates phosphatidylinositol 4,5-bisphosphate levels in migrating cells through an interaction with and activation of PIPKI alphaCellular functions of phosphatidylinositol 3-phosphate and FYVE domain proteinsThe Phox homology (PX) domain, a new player in phosphoinositide signallingConversion of PtdIns(4,5)P(2) into PtdIns(5)P by the S.flexneri effector IpgD reorganizes host cell morphologyA mammalian ortholog of Saccharomyces cerevisiae Vac14 that associates with and up-regulates PIKfyve phosphoinositide 5-kinase activityFunctional dissociation between PIKfyve-synthesized PtdIns5P and PtdIns(3,5)P2 by means of the PIKfyve inhibitor YM201636In vivo, Pikfyve generates PI(3,5)P2, which serves as both a signaling lipid and the major precursor for PI5P.The phosphoinositide kinase PIKfyve is vital in early embryonic development: preimplantation lethality of PIKfyve-/- embryos but normality of PIKfyve+/- miceA FYVE-finger-containing protein, Rabip4, is a Rab4 effector involved in early endosomal trafficAssembly of a Fab1 phosphoinositide kinase signaling complex requires the Fig4 phosphoinositide phosphatasePIKfyve-ArPIKfyve-Sac3 core complex: contact sites and their consequence for Sac3 phosphatase activity and endocytic membrane homeostasisPIKfyve: Partners, significance, debates and paradoxesArPIKfyve-PIKfyve interaction and role in insulin-regulated GLUT4 translocation and glucose transport in 3T3-L1 adipocytesArPIKfyve homomeric and heteromeric interactions scaffold PIKfyve and Sac3 in a complex to promote PIKfyve activity and functionalityDeciphering the roles of phosphoinositide lipids in phagolysosome biogenesisCharcot-Marie-Tooth disease and intracellular trafficInositol lipids: from an archaeal origin to phosphatidylinositol 3,5-bisphosphate faults in human diseasePhosphoinositides: Key modulators of energy metabolismPhosphoinositides in the mammalian endo-lysosomal networkAtg18 regulates organelle morphology and Fab1 kinase activity independent of its membrane recruitment by phosphatidylinositol 3,5-bisphosphatePhosphatidylinositol 3-phosphate-interacting domains in PIKfyve. Binding specificity and role in PIKfyve. Endomenbrane localizationActive PIKfyve associates with and promotes the membrane attachment of the late endosome-to-trans-Golgi network transport factor Rab9 effector p40Mammalian cell morphology and endocytic membrane homeostasis require enzymatically active phosphoinositide 5-kinase PIKfyveThe phox homology (PX) domain-dependent, 3-phosphoinositide-mediated association of sorting nexin-1 with an early sorting endosomal compartment is required for its ability to regulate epidermal growth factor receptor degradationThe PIKfyve inhibitor YM201636 blocks the continuous recycling of the tight junction proteins claudin-1 and claudin-2 in MDCK cellsLocalization and insulin-regulated relocation of phosphoinositide 5-kinase PIKfyve in 3T3-L1 adipocytesThe ML1Nx2 Phosphatidylinositol 3,5-Bisphosphate Probe Shows Poor Selectivity in CellsComplementation analysis in PtdInsP kinase-deficient yeast mutants demonstrates that Schizosaccharomyces pombe and murine Fab1p homologues are phosphatidylinositol 3-phosphate 5-kinasesMuscle-specific Pikfyve gene disruption causes glucose intolerance, insulin resistance, adiposity, and hyperinsulinemia but not muscle fiber-type switchingHost PI(3,5)P2 activity is required for Plasmodium berghei growth during liver stage infection.Human phosphatidylinositol 4-kinase isoform PI4K92. Expression of the recombinant enzyme and determination of multiple phosphorylation sites.Type I phosphatidylinositol 4-phosphate 5-kinase directly interacts with ADP-ribosylation factor 1 and is responsible for phosphatidylinositol 4,5-bisphosphate synthesis in the golgi compartment.
P2860
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P2860
PIKfyve, a mammalian ortholog of yeast Fab1p lipid kinase, synthesizes 5-phosphoinositides. Effect of insulin
description
1999 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 1999
@ast
im Juli 1999 veröffentlichter wissenschaftlicher Artikel
@de
scientific article (publication date: 30 July 1999)
@en
vedecký článok (publikovaný 1999/07/30)
@sk
vědecký článek publikovaný v roce 1999
@cs
wetenschappelijk artikel (gepubliceerd op 1999/07/30)
@nl
наукова стаття, опублікована в липні 1999
@uk
name
PIKfyve, a mammalian ortholog ...... oinositides. Effect of insulin
@ast
PIKfyve, a mammalian ortholog ...... oinositides. Effect of insulin
@en
PIKfyve, a mammalian ortholog ...... oinositides. Effect of insulin
@nl
type
label
PIKfyve, a mammalian ortholog ...... oinositides. Effect of insulin
@ast
PIKfyve, a mammalian ortholog ...... oinositides. Effect of insulin
@en
PIKfyve, a mammalian ortholog ...... oinositides. Effect of insulin
@nl
prefLabel
PIKfyve, a mammalian ortholog ...... oinositides. Effect of insulin
@ast
PIKfyve, a mammalian ortholog ...... oinositides. Effect of insulin
@en
PIKfyve, a mammalian ortholog ...... oinositides. Effect of insulin
@nl
P2093
P3181
P356
P1476
PIKfyve, a mammalian ortholog ...... oinositides. Effect of insulin
@en
P2093
A Shisheva
O C Ikonomov
P304
P3181
P356
10.1074/JBC.274.31.21589
P407
P577
1999-07-30T00:00:00Z