The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stress
about
EndoreplicationCheckpoint kinase 1 in DNA damage response and cell cycle regulationRoles of Chk1 in cell biology and cancer therapyAnalysis of kinase gene expression patterns across 5681 human tissue samples reveals functional genomic taxonomy of the kinomeConservation of pro-longevity genes among mammals.A phase II study of UCN-01 in combination with irinotecan in patients with metastatic triple negative breast cancer.Tipin-replication protein A interaction mediates Chk1 phosphorylation by ATR in response to genotoxic stress.The dual roles of geminin during trophoblast proliferation and differentiationAtaxin-3 promotes genome integrity by stabilizing Chk1.LRIG2 expression and prognosis in non-small cell lung cancer.PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damageChk1 inhibition as a novel therapeutic strategy for treating triple-negative breast and ovarian cancers.The interaction between checkpoint kinase 1 (Chk1) and the minichromosome maintenance (MCM) complex is required for DNA damage-induced Chk1 phosphorylation.Bioinformatic analysis of patient-derived ASPS gene expressions and ASPL-TFE3 fusion transcript levels identify potential therapeutic targetsUbcH7 regulates 53BP1 stability and DSB repairLoss of autophagy causes a synthetic lethal deficiency in DNA repair.The fork and the kinase: a DNA replication tale from a CHK1 perspective.Checkpoint kinase 1 prevents cell cycle exit linked to terminal cell differentiation.Predicting response to multidrug regimens in cancer patients using cell line experiments and regularised regression models.Phosphorylation of Minichromosome Maintenance 3 (MCM3) by Checkpoint Kinase 1 (Chk1) Negatively Regulates DNA Replication and Checkpoint Activation.SCF ubiquitin ligases in the maintenance of genome stability.And-1 coordinates with Claspin for efficient Chk1 activation in response to replication stressCoupling cellular localization and function of checkpoint kinase 1 (Chk1) in checkpoints and cell viabilityHuman cells enter mitosis with damaged DNA after treatment with pharmacological concentrations of genotoxic agents.Enhancement of cellular radiation sensitivity through degradation of Chk1 by the XIAP-XAF1 complex.A novel Chk1-binding peptide that enhances genotoxic sensitivity through the cellular redistribution of nuclear Chk1.Lack of Casein Kinase 1 Delta Promotes Genomic Instability - The Accumulation of DNA Damage and Down-Regulation of Checkpoint Kinase 1"The Octet": Eight Protein Kinases that Control Mammalian DNA Replication.Interferon-gamma enhances radiation-induced cell death via downregulation of Chk1.An SCF complex containing Fbxl12 mediates DNA damage-induced Ku80 ubiquitylation.Ubiquitination-mediated degradation of cell cycle-related proteins by F-box proteinsCandidate tumor suppressor BTG3 maintains genomic stability by promoting Lys63-linked ubiquitination and activation of the checkpoint kinase CHK1Radiation activated CHK1/MEPE pathway may contribute to microgravity-induced bone density loss.It takes two to tango: Ubiquitin and SUMO in the DNA damage response.The novel Chk1 inhibitor MK-8776 sensitizes human leukemia cells to HDAC inhibitors by targeting the intra-S checkpoint and DNA replication and repair.DNA polymerase κ-dependent DNA synthesis at stalled replication forks is important for CHK1 activation.Conformational Change of Human Checkpoint Kinase 1 (Chk1) Induced by DNA Damage.Glucose deprivation is associated with Chk1 degradation through the ubiquitin-proteasome pathway and effective checkpoint response to replication blocksMechanisms and function of substrate recruitment by F-box proteins.A Novel Function of F-Box Protein FBXO17 in Negative Regulation of Type I IFN Signaling by Recruiting PP2A for IFN Regulatory Factor 3 Deactivation.
P2860
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P2860
The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stress
description
2009 nî lūn-bûn
@nan
2009 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
The F box protein Fbx6 regulat ...... sitivity to replication stress
@ast
The F box protein Fbx6 regulat ...... sitivity to replication stress
@en
The F box protein Fbx6 regulat ...... sitivity to replication stress
@en-gb
The F box protein Fbx6 regulat ...... sitivity to replication stress
@nl
type
label
The F box protein Fbx6 regulat ...... sitivity to replication stress
@ast
The F box protein Fbx6 regulat ...... sitivity to replication stress
@en
The F box protein Fbx6 regulat ...... sitivity to replication stress
@en-gb
The F box protein Fbx6 regulat ...... sitivity to replication stress
@nl
prefLabel
The F box protein Fbx6 regulat ...... sitivity to replication stress
@ast
The F box protein Fbx6 regulat ...... sitivity to replication stress
@en
The F box protein Fbx6 regulat ...... sitivity to replication stress
@en-gb
The F box protein Fbx6 regulat ...... sitivity to replication stress
@nl
P2093
P2860
P921
P3181
P1433
P1476
The F box protein Fbx6 regulat ...... sitivity to replication stress
@en
P2093
Aaron Aslanian
Chris Coughlin
John Brognard
Marisa Dolled-Filhart
Robert T Abraham
Tony Hunter
You-Wei Zhang
Zhongsheng You
P2860
P304
P3181
P356
10.1016/J.MOLCEL.2009.06.030
P407
P577
2009-08-28T00:00:00Z