mTOR generates an auto-amplification loop by triggering the βTrCP- and CK1α-dependent degradation of DEPTOR - Wikidata - wikimedia - TriplyDB

mTOR generates an auto-amplification loop by triggering the βTrCP- and CK1α-dependent degradation of DEPTOR

mTOR generates an auto-amplification loop by triggering the βTrCP- and CK1α-dependent degradation of DEPTOR

http://www.wikidata.org/entity/Q28251047

about

The CK1 Family: Contribution to Cellular Stress Response and Its Role in Carcinogenesis FBXL2- and PTPL1-mediated degradation of p110-free p85β regulatory subunit controls the PI(3)K signalling cascade SCF(β-TRCP)-mediated degradation of NEDD4 inhibits tumorigenesis through modulating the PTEN/Akt signaling pathway Cullin-RING ligases in regulation of autophagy The role of cullin 5-containing ubiquitin ligases mTOR-dependent cell survival mechanisms Shedding new light on neurodegenerative diseases through the mammalian target of rapamycin mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas Targeting Cullin-RING ligases by MLN4924 induces autophagy via modulating the HIF1-REDD1-TSC1-mTORC1-DEPTOR axis.Loss of hepatic DEPTOR alters the metabolic transition to fasting Circadian gene variants in cancer.Nutrient signaling to mTOR and cell growth.Targeting Neddylation pathways to inactivate cullin-RING ligases for anticancer therapy β-TrCP1 degradation is a novel action mechanism of PI3K/mTOR inhibitors in triple-negative breast cancer cells.The endosomal sorting complex required for transport pathway mediates chemokine receptor CXCR4-promoted lysosomal degradation of the mammalian target of rapamycin antagonist DEPTOR.Che-1-induced inhibition of mTOR pathway enables stress-induced autophagy.Rapid mitogenic regulation of the mTORC1 inhibitor, DEPTOR, by phosphatidic acid.Linking metabolism and cell cycle progression via the APC/CCdh1 and SCFβTrCP ubiquitin ligases Rapamycin inhibits lymphatic endothelial cell tube formation by downregulating vascular endothelial growth factor receptor 3 protein expression.Targeting the mTOR-DEPTOR pathway by CRL E3 ubiquitin ligases: therapeutic application An evolving role for DEPTOR in tumor development and progression.S6 Kinase- and β-TrCP2-Dependent Degradation of p19Arf Is Required for Cell Proliferation Cytotoxic Properties of a DEPTOR-mTOR Inhibitor in Multiple Myeloma Cells.DEPTOR ubiquitination and destruction by SCF(β-TrCP).Understanding cullin-RING E3 biology through proteomics-based substrate identification Regulator of cullins-1 expression knockdown suppresses the malignant progression of muscle-invasive transitional cell carcinoma by regulating mTOR/DEPTOR pathway.Induction of autophagy and senescence by knockdown of ROC1 E3 ubiquitin ligase to suppress the growth of liver cancer cells.Small molecule therapeutics targeting F-box proteins in cancer.Transforming growth factor β integrates Smad 3 to mechanistic target of rapamycin complexes to arrest deptor abundance for glomerular mesangial cell hypertrophy.Regulation of the CRL4(Cdt2) ubiquitin ligase and cell-cycle exit by the SCF(Fbxo11) ubiquitin ligase Proteasomal degradation of eukaryotic elongation factor-2 kinase (EF2K) is regulated by cAMP-PKA signaling and the SCFβTRCP ubiquitin E3 ligase DEPTOR suppresses the progression of esophageal squamous cell carcinoma and predicts poor prognosis.DEPTOR regulates vascular endothelial cell activation and proinflammatory and angiogenic responses.XPLN is an endogenous inhibitor of mTORC2.DEPTOR promotes survival of cervical squamous cell carcinoma cells and its silencing induces apoptosis through downregulating PI3K/AKT and by up-regulating p38 MAP kinase Mechanisms and function of substrate recruitment by F-box proteins.Coordinate regulation of autophagy and the ubiquitin proteasome system by MTOR.Role of SKP1-CUL1-F-box-protein (SCF) E3 ubiquitin ligases in skin cancer.The interplay between HPIP and casein kinase 1α promotes renal cell carcinoma growth and metastasis via activation of mTOR pathway.

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mTOR generates an auto-amplification loop by triggering the βTrCP- and CK1α-dependent degradation of DEPTOR

http://www.wikidata.org/entity/Q28251047

description

2011 nî lūn-bûn

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2011 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

mTOR generates an auto-amplifi ...... ependent degradation of DEPTOR

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mTOR generates an auto-amplifi ...... ependent degradation of DEPTOR

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mTOR generates an auto-amplifi ...... ependent degradation of DEPTOR

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type

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mTOR generates an auto-amplifi ...... ependent degradation of DEPTOR

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mTOR generates an auto-amplifi ...... ependent degradation of DEPTOR

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mTOR generates an auto-amplifi ...... ependent degradation of DEPTOR

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mTOR generates an auto-amplifi ...... ependent degradation of DEPTOR

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mTOR generates an auto-amplifi ...... ependent degradation of DEPTOR

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mTOR generates an auto-amplifi ...... ependent degradation of DEPTOR

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J.MOLCEL.2011.09.005

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mTOR generates an auto-amplifi ...... ependent degradation of DEPTOR

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Alfredo Toschi

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Jeffrey R Skaar

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Michele Pagano

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Naama Kanarek

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Shafi Kuchay

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Shanshan Duan

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Yinon Ben-Neriah

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P2860

SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response

Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase

DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival

Systematic analysis and nomenclature of mammalian F-box proteins

mTOR: from growth signal integration to cancer, diabetes and ageing

Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer

Homodimer of two F-box proteins betaTrCP1 or betaTrCP2 binds to IkappaBalpha for signal-dependent ubiquitination

A noncanonical sequence phosphorylated by casein kinase 1 in beta-catenin may play a role in casein kinase 1 targeting of important signaling proteins

Genetic evidence for the essential role of beta-transducin repeat-containing protein in the inducible processing of NF-kappa B2/p100

Defining the role of mTOR in cancer

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10.1016/J.MOLCEL.2011.09.005

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22017877

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