Bone overgrowth-associated mutations in the LRP4 gene impair sclerostin facilitator function
about
Mutations affecting the BHLHA9 DNA-binding domain cause MSSD, mesoaxial synostotic syndactyly with phalangeal reduction, Malik-Percin typeSclerostin Inhibition in the Management of OsteoporosisFrom disease to treatment: from rare skeletal disorders to treatments for osteoporosisMolecular Aspects of Bone Resorption in β-Thalassemia MajorIn vitro and in vivo approaches to study osteocyte biologyWNT signaling in bone development and homeostasisThe osteocyte as a therapeutic target in the treatment of osteoporosisOsteocytes: master orchestrators of boneModulating Bone Resorption and Bone Formation in Opposite Directions in the Treatment of Postmenopausal OsteoporosisFriend or foe: high bone mineral density on routine bone density scanning, a review of causes and managementWNT signaling in bone homeostasis and disease: from human mutations to treatmentsMesdc2 plays a key role in cell-surface expression of Lrp4 and postsynaptic specialization in myotubesLRP4 third β-propeller domain mutations cause novel congenital myasthenia by compromising agrin-mediated MuSK signaling in a position-specific manner.Sclerostin stimulates osteocyte support of osteoclast activity by a RANKL-dependent pathwayWise regulates bone deposition through genetic interactions with Lrp5Developments in sclerostin biology: regulation of gene expression, mechanisms of action, and physiological functions.Updating the Wnt pathways.Wnt signaling and the control of human stem cell fate.Disruption of Lrp4 function by genetic deletion or pharmacological blockade increases bone mass and serum sclerostin levelsAnti-Sclerostin antibody inhibits internalization of Sclerostin and Sclerostin-mediated antagonism of Wnt/LRP6 signaling.Composite selection signals can localize the trait specific genomic regions in multi-breed populations of cattle and sheepLrp4 in osteoblasts suppresses bone formation and promotes osteoclastogenesis and bone resorptionRapid skeletal turnover in a radiographic mimic of osteopetrosis.Adult Brtl/+ mouse model of osteogenesis imperfecta demonstrates anabolic response to sclerostin antibody treatment with increased bone mass and strength.Transcriptional Profiling of Laser Capture Microdissected Subpopulations of the Osteoblast Lineage Provides Insight Into the Early Response to Sclerostin Antibody in Rats.A Novel Loss-of-Sclerostin Function Mutation in a First Egyptian Family with SclerosteosisMutations in DVL1 cause an osteosclerotic form of Robinow syndrome.TGF-β regulates sclerostin expression via the ECR5 enhancer.A Comprehensive Overview of Skeletal Phenotypes Associated with Alterations in Wnt/β-catenin Signaling in Humans and Mice.The regulation of osteoclast differentiation by Wnt signalsImpaired Synaptic Development, Maintenance, and Neuromuscular Transmission in LRP4-Related Myasthenia.Update on Wnt signaling in bone cell biology and bone disease.Sclerostin inhibits osteoblast differentiation without affecting BMP2/SMAD1/5 or Wnt3a/β-catenin signaling but through activation of platelet-derived growth factor receptor signaling in vitroSclerostin antibody improves skeletal parameters in a Brtl/+ mouse model of osteogenesis imperfecta.Polyhydramnios in Lrp4 knockout mice with bilateral kidney agenesis: Defects in the pathways of amniotic fluid clearanceIntegration of multiple signaling pathways determines differences in the osteogenic potential and tissue regeneration of neural crest-derived and mesoderm-derived calvarial bonesMutations in Known Monogenic High Bone Mass Loci Only Explain a Small Proportion of High Bone Mass CasesPostnatal β-catenin deletion from Dmp1-expressing osteocytes/osteoblasts reduces structural adaptation to loading, but not periosteal load-induced bone formationLRP5 and bone mass regulation: Where are we now?Genome-wide approaches for identifying genetic risk factors for osteoporosis.
P2860
1b439b58409213dd8945834313638e1290b84f73214c2ff506ce9e72f2526001b22ad0a5db1dc4e142d480278488ac14a1edaa1863e034206de7b28d58a311128f92f43ab89c851af983fdfcea18abe55cac814743bb9fd21a60800cbb3747c2cfdcb0569cb5049b17b3cddcb880c6b9797e0ef4687c081cccdb1753abafb2ba7b5c14c123d5ec1844d81130d6cf6c976fedbe2ff845d7e4597b00ddf0d7d25b
P248
Q24307947-CEECBAFC-F1B4-43F4-BA7D-79208E7B8E43Q26750713-0E7103E3-99DF-4A06-AB4B-E5A0791CADD3Q26764854-591E2295-DF72-480A-BACC-CC76190DCC85Q26801066-AFFB160B-76B2-4690-A46D-13AA41EE0640Q26858876-D8A1D4FC-63D5-4D52-A4F5-F673BC79BDF8Q27008570-74EDCD83-317D-4E67-9080-6D0972906228Q27009129-4EF5F449-941C-4BA2-BD9F-5DCF8BD7F687Q27022407-9D0736CE-8DD1-4374-A7BA-091CE6D4C912Q27022580-49DABFAD-358B-4F3A-8941-2BE6C53F6B34Q27025982-6A6391C0-5973-4E3A-BBFD-79D4AED09D4AQ28285090-813F6A36-B7BD-419B-BB35-A19B751381DFQ28587805-4B9A4AD1-362B-4A89-AB46-0655C0CBC02FQ30573427-22B47F86-A088-4A82-A52B-347805619424Q31032805-A65EAC40-9CCC-4597-965B-0139DC0DCB86Q33553692-09352B46-8763-43DE-A1A1-0AF5F40FC9C4Q33564617-268A221A-80E6-4A82-AAEA-D99F57BBE5B5Q34360489-8BDED0EA-5C3C-4839-885E-693E20623A98Q34658275-4F4709C4-468F-443F-92BF-FA22846A15E1Q34661015-8176E693-13FA-4688-B37C-378692357759Q34701183-B2408604-51D4-4F16-802B-A7E8A173D7C7Q35122561-CF4F46B0-C27B-48B9-88CC-FF7A579A8757Q35212647-40E38DDE-8D54-4236-9FD9-28F2CB45DDBDQ35343702-558AD95B-7560-4721-BAA6-D054F177B0F4Q35555545-9F7BD780-8416-477A-9281-56A5B0720DA5Q35560337-F80D96EF-71BD-4094-AAFF-FB778C5FA740Q35578826-FF1A93F5-AFEB-48B0-8138-22D368AFB5FFQ35589023-3B8E241D-4F38-4282-A0A7-97DFEFFD02C7Q35754103-C627E580-E7A9-495B-94F9-D3C55667B2E2Q35755034-88BAC1CB-F6C6-4D47-8FD2-341D77655D70Q35831159-6C46B644-C576-40BF-9563-1F9A06257FD6Q35940605-946CCCC5-9EEF-42E1-A1DF-0880C051A9E2Q36083303-B0005F27-8E67-48F7-AC2B-4B37A9588B20Q36256294-D1E4CF2D-2640-43CE-A71D-9FDF303F25AEQ36472781-3A6625BF-CC98-472D-AA98-565AF6C8A61CQ36548831-D490D78D-E80C-4296-8244-D984B56A6250Q36790379-BCD0BF0C-A124-46CA-A20A-BADCC2461F92Q36799783-055E8118-A298-4DDA-AEAA-50B217142C26Q36984381-DD0A02C8-A889-47BA-A467-2A3D737DF775Q36995895-A222AF6C-654B-4F25-AC78-6581B0D2A11AQ36998445-16AEB4ED-CDCC-444F-8D13-13EACF201805
P2860
Bone overgrowth-associated mutations in the LRP4 gene impair sclerostin facilitator function
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Bone overgrowth-associated mut ...... clerostin facilitator function
@ast
Bone overgrowth-associated mut ...... clerostin facilitator function
@en
Bone overgrowth-associated mut ...... clerostin facilitator function
@nl
type
label
Bone overgrowth-associated mut ...... clerostin facilitator function
@ast
Bone overgrowth-associated mut ...... clerostin facilitator function
@en
Bone overgrowth-associated mut ...... clerostin facilitator function
@nl
prefLabel
Bone overgrowth-associated mut ...... clerostin facilitator function
@ast
Bone overgrowth-associated mut ...... clerostin facilitator function
@en
Bone overgrowth-associated mut ...... clerostin facilitator function
@nl
P2093
P2860
P50
P921
P3181
P356
P1476
Bone overgrowth-associated mut ...... clerostin facilitator function
@en
P2093
Andreas Bauer
Chris X Lu
Christine Halleux
Elke Piters
Feliciano J Ramos Fuentes
Fenna de Freitas
Frederic Morvan
Hilmar Ebersbach
Ina Kramer
Karen Jennes
P2860
P304
P3181
P356
10.1074/JBC.M110.190330
P407
P577
2011-06-03T00:00:00Z