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Transcription promotes contraction of CAG repeat tracts in human cells

Transcription promotes contraction of CAG repeat tracts in human cells

http://www.wikidata.org/entity/Q24300192

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New insights into repeat instability: role of RNA•DNA hybrids DNA slip-outs cause RNA polymerase II arrest in vitro: potential implications for genetic instability Zinc-finger directed double-strand breaks within CAG repeat tracts promote repeat instability in human cells DNA triplet repeat expansion and mismatch repair New functions of Ctf18-RFC in preserving genome stability outside its role in sister chromatid cohesion.Expansion, mosaicism and interruption: mechanisms of the CAG repeat mutation in spinocerebellar ataxia type 1 GFP-based fluorescence assay for CAG repeat instability in cultured human cells Genetic Instability Caused by Loss of MutS Homologue 3 in Human Colorectal Cancer Transcription-coupled DNA repair: two decades of progress and surprises Incision-dependent and error-free repair of (CAG)(n)/(CTG)(n) hairpins in human cell extracts Processing of double-R-loops in (CAG)·(CTG) and C9orf72 (GGGGCC)·(GGCCCC) repeats causes instability.Opposing effects of the UV lesion repair protein XPA and UV bypass polymerase eta on ATR checkpoint signaling.Diverse effects of individual mismatch repair components on transcription-induced CAG repeat instability in human cells.Progressive GAA.TTC repeat expansion in human cell lines.Double-strand break repair pathways protect against CAG/CTG repeat expansions, contractions and repeat-mediated chromosomal fragility in Saccharomyces cerevisiae Convergent transcription through a long CAG tract destabilizes repeats and induces apoptosis R loops stimulate genetic instability of CTG.CAG repeats.Expanded CAG/CTG repeat DNA induces a checkpoint response that impacts cell proliferation in Saccharomyces cerevisiae.Topoisomerase 1 and single-strand break repair modulate transcription-induced CAG repeat contraction in human cells.Xpa deficiency reduces CAG trinucleotide repeat instability in neuronal tissues in a mouse model of SCA1.X inactivation plays a major role in the gender bias in somatic expansion in a mouse model of the fragile X-related disorders: implications for the mechanism of repeat expansion.Complementary roles for exonuclease 1 and Flap endonuclease 1 in maintenance of triplet repeats RNA-protein interactions in unstable microsatellite diseases.DNA methyltransferases, DNA damage repair, and cancer Msh2 acts in medium-spiny striatal neurons as an enhancer of CAG instability and mutant huntingtin phenotypes in Huntington's disease knock-in mice Hsp90 modulates CAG repeat instability in human cells.Nucleotide excision repair, mismatch repair, and R-loops modulate convergent transcription-induced cell death and repeat instability Bidirectional transcription stimulates expansion and contraction of expanded (CTG)*(CAG) repeats.Non-B DNA structure-induced genetic instability and evolution.Transcription elongation and tissue-specific somatic CAG instability.Role of transcript and interplay between transcription and replication in triplet-repeat instability in mammalian cells.Making sense of intratumor genetic heterogeneity: altered frequency of androgen receptor CAG repeat length variants in breast cancer tissues.MSH3 polymorphisms and protein levels affect CAG repeat instability in Huntington's disease mice Determinants of R-loop formation at convergent bidirectionally transcribed trinucleotide repeats A 5', 8-cyclo-2'-deoxypurine lesion induces trinucleotide repeat deletion via a unique lesion bypass by DNA polymerase β Replication fork regression in repetitive DNAs.CAG*CTG repeat instability in cultured human astrocytes Epigenetic therapy for Friedreich ataxia Epigenetic mechanisms and genome stability.Mechanisms of trinucleotide repeat instability during human development

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Transcription promotes contraction of CAG repeat tracts in human cells

http://www.wikidata.org/entity/Q24300192

description

2006 nî lūn-bûn

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2006 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2006 թվականի փետրվարին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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name

Transcription promotes contraction of CAG repeat tracts in human cells

@ast

Transcription promotes contraction of CAG repeat tracts in human cells

@en

Transcription promotes contraction of CAG repeat tracts in human cells

@en-gb

Transcription promotes contraction of CAG repeat tracts in human cells

@nl

type

label

Transcription promotes contraction of CAG repeat tracts in human cells

@ast

Transcription promotes contraction of CAG repeat tracts in human cells

@en

Transcription promotes contraction of CAG repeat tracts in human cells

@en-gb

Transcription promotes contraction of CAG repeat tracts in human cells

@nl

prefLabel

Transcription promotes contraction of CAG repeat tracts in human cells

@ast

Transcription promotes contraction of CAG repeat tracts in human cells

@en

Transcription promotes contraction of CAG repeat tracts in human cells

@en-gb

Transcription promotes contraction of CAG repeat tracts in human cells

@nl

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P1433

Nature Structural & Molecular Biology

P1476

Transcription promotes contraction of CAG repeat tracts in human cells

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P2093

John H Wilson

http://www.w3.org/2001/XMLSchema#string

Yunfu Lin

http://www.w3.org/2001/XMLSchema#string

P2860

Role of Saccharomyces cerevisiae Msh2 and Msh3 repair proteins in double-strand break-induced recombination.

Msh2 deficiency prevents in vivo somatic instability of the CAG repeat in Huntington disease transgenic mice

hMutSbeta is required for the recognition and uncoupling of psoralen interstrand cross-links in vitro

CTG repeat instability and size variation timing in DNA repair-deficient mice.

Repeat instability: mechanisms of dynamic mutations.

Physical interaction between components of DNA mismatch repair and nucleotide excision repair

Nucleotide excision repair affects the stability of long transcribed (CTG*CAG) tracts in an orientation-dependent manner in Escherichia coli

Selectable system for monitoring the instability of CTG/CAG triplet repeats in mammalian cells.

Somatic expansion behaviour of the (CTG)n repeat in myotonic dystrophy knock-in mice is differentially affected by Msh3 and Msh6 mismatch-repair proteins.

Dramatic, expansion-biased, age-dependent, tissue-specific somatic mosaicism in a transgenic mouse model of triplet repeat instability.

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179-180

http://www.w3.org/2001/XMLSchema#string

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scholarly article

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2620071

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10.1038/NSMB1042

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2

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13

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2006-01-01T00:00:00Z

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7383682

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1041064839

http://www.w3.org/2001/XMLSchema#string

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16388310

http://www.w3.org/2001/XMLSchema#string

P921

maintenance of DNA repeat elements