Somatic expansion behaviour of the (CTG)n repeat in myotonic dystrophy knock-in mice is differentially affected by Msh3 and Msh6 mismatch-repair proteins.
about
Transcription promotes contraction of CAG repeat tracts in human cellsMechanism of mismatch recognition revealed by human MutSβ bound to unpaired DNA loopsDNA mismatch repair: molecular mechanism, cancer, and ageingMechanistic features of CAG*CTG repeat contractions in cultured cells revealed by a novel genetic assayInverted repeat-stimulated sister-chromatid exchange events are RAD1-independent but reduced in a msh2 mutant.Advances in mechanisms of genetic instability related to hereditary neurological diseases.Muscle wasting in myotonic dystrophies: a model of premature agingDNA triplet repeat expansion and mismatch repairRepeat-mediated genetic and epigenetic changes at the FMR1 locus in the Fragile X-related disordersA MutSβ-Dependent Contribution of MutSα to Repeat Expansions in Fragile X Premutation Mice?Suppression of Somatic Expansion Delays the Onset of Pathophysiology in a Mouse Model of Huntington’s DiseaseContinuous and periodic expansion of CAG repeats in Huntington's disease R6/1 miceMolecular genetics and genetic testing in myotonic dystrophy type 1.The 26S proteasome drives trinucleotide repeat expansionsMrc1, Tof1 and Csm3 inhibit CAG.CTG repeat instability by at least two mechanisms.Ups and Downs: Mechanisms of Repeat Instability in the Fragile X-Related DisordersNew insights into the mechanism of DNA mismatch repairStructural, molecular and cellular functions of MSH2 and MSH6 during DNA mismatch repair, damage signaling and other noncanonical activitiesLocalization of MMR proteins on meiotic chromosomes in mice indicates distinct functions during prophase IPms2 suppresses large expansions of the (GAA·TTC)n sequence in neuronal tissuesOnset and progression of behavioral and molecular phenotypes in a novel congenic R6/2 line exhibiting intergenerational CAG repeat stability.MutSβ promotes trinucleotide repeat expansion by recruiting DNA polymerase β to nascent (CAG)n or (CTG)n hairpins for error-prone DNA synthesisIsolated short CTG/CAG DNA slip-outs are repaired efficiently by hMutSbeta, but clustered slip-outs are poorly repaired.Somatic CTG*CAG repeat instability in a mouse model for myotonic dystrophy type 1 is associated with changes in cell nuclearity and DNA ploidy.Huntington disease expansion mutations in humans can occur before meiosis is completed.CTCF cis-regulates trinucleotide repeat instability in an epigenetic manner: a novel basis for mutational hot spot determination.MSH2 ATPase domain mutation affects CTG*CAG repeat instability in transgenic mice.Diverse effects of individual mismatch repair components on transcription-induced CAG repeat instability in human cells.Progressive GAA.TTC repeat expansion in human cell lines.A novel approach to investigate tissue-specific trinucleotide repeat instability.Intergenerational and striatal CAG repeat instability in Huntington's disease knock-in mice involve different DNA repair genesConvergent transcription through a long CAG tract destabilizes repeats and induces apoptosisTopoisomerase 1 and single-strand break repair modulate transcription-induced CAG repeat contraction in human cells.Intergenerational instability of the expanded CTG repeat in the DMPK gene: studies in human gametes and preimplantation embryos.Xpa deficiency reduces CAG trinucleotide repeat instability in neuronal tissues in a mouse model of SCA1.Correlation of inter-locus polyglutamine toxicity with CAG•CTG triplet repeat expandability and flanking genomic DNA GC contentHistone deacetylase complexes promote trinucleotide repeat expansionsThe nucleotide binding dynamics of human MSH2-MSH3 are lesion dependentTranscription elongation and tissue-specific somatic CAG instability.Role of transcript and interplay between transcription and replication in triplet-repeat instability in mammalian cells.
P2860
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P2860
Somatic expansion behaviour of the (CTG)n repeat in myotonic dystrophy knock-in mice is differentially affected by Msh3 and Msh6 mismatch-repair proteins.
description
2002 nî lūn-bûn
@nan
2002年の論文
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2002年学术文章
@wuu
2002年学术文章
@zh
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh-hant
name
Somatic expansion behaviour of ...... Msh6 mismatch-repair proteins.
@en
Somatic expansion behaviour of the
@nl
type
label
Somatic expansion behaviour of ...... Msh6 mismatch-repair proteins.
@en
Somatic expansion behaviour of the
@nl
prefLabel
Somatic expansion behaviour of ...... Msh6 mismatch-repair proteins.
@en
Somatic expansion behaviour of the
@nl
P2093
P356
P1476
Somatic expansion behaviour of ...... Msh6 mismatch-repair proteins.
@en
P2093
Bé Wieringa
Derick G Wansink
Hein te Riele
Marcel R Nelen
Marga M Coerwinkel
Patricia J T A Groenen
Walther J A A van den Broek
P304
P356
10.1093/HMG/11.2.191
P577
2002-01-01T00:00:00Z