Conservation in the mechanism of Nedd8 activation by the human AppBp1-Uba3 heterodimer
about
A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8The UbcH8 ubiquitin E2 enzyme is also the E2 enzyme for ISG15, an IFN-alpha/beta-induced ubiquitin-like proteinUbiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathwaysThe Role of the COP9 Signalosome and Neddylation in DNA Damage Signaling and RepairBasis for a ubiquitin-like protein thioester switch toggling E1–E2 affinityThe Intrinsic Affinity between E2 and the Cys Domain of E1 in Ubiquitin-like ModificationsStructural Dissection of a Gating Mechanism Preventing Misactivation of Ubiquitin by NEDD8’s E1 † ‡How the MccB bacterial ancestor of ubiquitin E1 initiates biosynthesis of the microcin C7 antibioticEssentiality of a non-RING element in priming donor ubiquitin for catalysis by a monomeric E3E2-binding surface on Uba3 β-grasp domain undergoes a conformational transitionISG15 Arg151 and the ISG15-conjugating enzyme UbE1L are important for innate immune control of Sindbis virusRole of the Zn(2+) motif of E1 in SUMO adenylationUbiquitylation, neddylation and the DNA damage responsePleiotropic effects of ATP.Mg2+ binding in the catalytic cycle of ubiquitin-activating enzymeDemonstration of ubiquitin thiolester formation of UBE2Q2 (UBCi), a novel ubiquitin-conjugating enzyme with implantation site-specific expressionOrthogonal ubiquitin transfer through engineered E1-E2 cascades for protein ubiquitinationNedd8 on cullin: building an expressway to protein destruction.Protein neddylation: beyond cullin-RING ligases.Targeting cullin-RING ligases for cancer treatment: rationales, advances and therapeutic implications.Redesigning the NEDD8 pathway with a bacterial genetic screen for ubiquitin-like molecule transfer.The NEDD8 Conjugation Pathway and Its Relevance in Cancer Biology and Therapy.Twists and turns in ubiquitin-like protein conjugation cascades.Ser(120) of Ubc2/Rad6 regulates ubiquitin-dependent N-end rule targeting by E3{alpha}/Ubr1Targeting Neddylation pathways to inactivate cullin-RING ligases for anticancer therapyMacromolecular juggling by ubiquitylation enzymes.Phage display to identify Nedd8-mimicking peptides as inhibitors of the Nedd8 transfer cascade.Profiling the cross reactivity of ubiquitin with the Nedd8 activating enzyme by phage display.Ubiquitin and ubiquitin-modified proteins activate the Pseudomonas aeruginosa T3SS cytotoxin, ExoU.E1-E2 interactions in ubiquitin and Nedd8 ligation pathways.Ubiquitin-like protein activation.ElaD, a Deubiquitinating protease expressed by E. coliMechanistic studies on activation of ubiquitin and di-ubiquitin-like protein, FAT10, by ubiquitin-like modifier activating enzyme 6, Uba6Measuring rates of ubiquitin chain formation as a functional readout of ligase activityProteomic analysis of cellular soluble proteins from human bronchial smooth muscle cells by combining nondenaturing micro 2DE and quantitative LC-MS/MS. 2. Similarity search between protein maps for the analysis of protein complexes.MLN4924: a novel first-in-class inhibitor of NEDD8-activating enzyme for cancer therapy.Targeting the protein ubiquitination machinery in melanoma by the NEDD8-activating enzyme inhibitor pevonedistat (MLN4924).Mechanistic study of Uba5 enzyme and the Ufm1 conjugation pathway.Ubiquitin-like Protein Conjugation: Structures, Chemistry, and Mechanism.Mechanistic studies of substrate-assisted inhibition of ubiquitin-activating enzyme by adenosine sulfamate analogues.A gatekeeper residue for NEDD8-activating enzyme inhibition by MLN4924.
P2860
Q24303664-BDD038F6-4869-4F6A-B0BC-19401B9DE6D1Q24562149-D252CB80-B58B-4A4A-BC7D-042002F2841EQ24647626-97B227E8-F914-4916-969E-30695D7A915CQ26782011-F2B2EE13-C0D4-4956-826A-ABC8F8926D55Q27641129-F738A454-F5EA-4E49-901B-033643AD4138Q27646842-468A5D8A-12F1-4AFC-8741-C8B504942988Q27651318-22E96DA1-9A1A-465B-8938-DA90BA9A3D9BQ27655732-674694C0-1F3F-4E10-BC11-2A6BF820005BQ27679081-DD5DDA26-FB93-4B3A-A76F-E14D5EAC91C1Q27681811-89C9B19B-D8C6-4A5A-9D91-3F2AD42AB72EQ27865223-D3F922EF-55F9-4C4A-8203-FD0C957F6C4CQ27865252-77736E56-30BF-48FE-8FDE-9A2915C14D93Q28087342-74FDD7F6-4394-4B23-9571-DC2FCF4EB49EQ28305802-E69655C8-92ED-4B40-8C7D-2C4E1F462E09Q28505344-F865064E-76FC-4B91-8F47-7651D50A5C0EQ33924565-A0705AEE-8876-4BDD-A816-8238CBEA6C98Q33976667-7F9FD82B-7FDC-4BFD-B23D-72AADC301688Q34042816-27E449DD-B252-4E71-81E4-ED695305B983Q34043821-1701F413-0C80-47FC-9E3B-F8B2BCDE045AQ34185122-D1AF6F8A-9944-4CAE-99C1-9A91F109C3B9Q34202686-95BCDA8E-FB45-4130-AEE8-AD86675E64AAQ34225698-5739E597-BE4E-4D7A-AACF-3D8769635D03Q34438710-04A3BCFF-1C18-4723-A2B1-84A985F16C76Q34563129-C8A029F4-8239-4CA9-9780-43172B7636F0Q34782977-BBB72591-D572-4B93-AE13-975B36384372Q34793372-CFFD9C4E-BD31-4B96-9CC6-1C5D1C9AEF5DQ34925373-0887A81D-E223-4E1B-BF07-10B2A84C4F8CQ35613242-D77406FA-AA29-461A-AF95-0CD909690FBCQ35643657-C6A19B52-3A71-470A-8AF8-EE9FD32D8ED5Q35691524-9C9C5899-6BDC-4B91-A238-1AAC2C904748Q35741864-7299837A-E278-4F32-B430-A06ADD368592Q35939802-82E0358B-B897-4C29-9B97-2D9C311E968DQ36630645-52F6C566-F56C-4EB3-A16C-D808EFF510FEQ37505599-DBFDAF09-6EA1-4FC0-A4DF-A4FB61F420D6Q38026589-28694BA5-E287-4BDE-A6AD-4268C299419BQ38736706-80DD863C-23CA-422D-B603-F9EFA2A885E7Q38981169-B6DD2740-0C89-4AE1-82DD-4B000BEAFA9BQ39149390-82F642B5-935B-47D3-9252-1847E3FB1B71Q39241849-9B774DF8-0DE0-43D6-8BCD-F9AB592BEB73Q39308261-4B7F6AE5-76F5-4294-A467-F6F1C7C5F852
P2860
Conservation in the mechanism of Nedd8 activation by the human AppBp1-Uba3 heterodimer
description
2003 nî lūn-bûn
@nan
2003 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Conservation in the mechanism of Nedd8 activation by the human AppBp1-Uba3 heterodimer
@ast
Conservation in the mechanism of Nedd8 activation by the human AppBp1-Uba3 heterodimer
@en
Conservation in the mechanism of Nedd8 activation by the human AppBp1-Uba3 heterodimer
@en-gb
Conservation in the mechanism of Nedd8 activation by the human AppBp1-Uba3 heterodimer
@nl
type
label
Conservation in the mechanism of Nedd8 activation by the human AppBp1-Uba3 heterodimer
@ast
Conservation in the mechanism of Nedd8 activation by the human AppBp1-Uba3 heterodimer
@en
Conservation in the mechanism of Nedd8 activation by the human AppBp1-Uba3 heterodimer
@en-gb
Conservation in the mechanism of Nedd8 activation by the human AppBp1-Uba3 heterodimer
@nl
prefLabel
Conservation in the mechanism of Nedd8 activation by the human AppBp1-Uba3 heterodimer
@ast
Conservation in the mechanism of Nedd8 activation by the human AppBp1-Uba3 heterodimer
@en
Conservation in the mechanism of Nedd8 activation by the human AppBp1-Uba3 heterodimer
@en-gb
Conservation in the mechanism of Nedd8 activation by the human AppBp1-Uba3 heterodimer
@nl
P2860
P921
P356
P1476
Conservation in the mechanism of Nedd8 activation by the human AppBp1-Uba3 heterodimer
@en
P2093
Arthur L Haas
Richard N Bohnsack
P2860
P304
P356
10.1074/JBC.M303177200
P407
P577
2003-07-18T00:00:00Z