Targeting Neddylation pathways to inactivate cullin-RING ligases for anticancer therapy
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The structure and regulation of Cullin 2 based E3 ubiquitin ligases and their biological functionsCullin-RING ligases in regulation of autophagyUbiquitylation, neddylation and the DNA damage responseChemogenomic Study of Carboplatin in Saccharomyces cerevisiae: Inhibition of the NEDDylation Process Overcomes Cellular Resistance Mediated by HuR and Cullin ProteinsNEDD8 ultimate buster-1 regulates the abundance of TRF1 at telomeres by promoting its proteasomal degradationDistinct outcomes of CRL-Nedd8 pathway inhibition reveal cancer cell plasticityInhibition of Neddylation Modification Sensitizes Pancreatic Cancer Cells to Gemcitabine.MLN4924 (Pevonedistat), a protein neddylation inhibitor, suppresses proliferation and migration of human clear cell renal cell carcinomaNeddylation pathway is up-regulated in human intrahepatic cholangiocarcinoma and serves as a potential therapeutic targetInactivating UBE2M impacts the DNA damage response and genome integrity involving multiple cullin ligases.Synergistic inhibition of autophagy and neddylation pathways as a novel therapeutic approach for targeting liver cancer.Neddylation inhibitor MLN4924 suppresses growth and migration of human gastric cancer cells.Blockage of neddylation modification stimulates tumor sphere formation in vitro and stem cell differentiation and wound healing in vivoRadiosensitization by the investigational NEDD8-activating enzyme inhibitor MLN4924 (pevonedistat) in hormone-resistant prostate cancer cells.Depletion of SAG/RBX2 E3 ubiquitin ligase suppresses prostate tumorigenesis via inactivation of the PI3K/AKT/mTOR axis.The β-TrCP-FBXW2-SKP2 axis regulates lung cancer cell growth with FBXW2 acting as a tumour suppressor.FBXW7 Facilitates Nonhomologous End-Joining via K63-Linked Polyubiquitylation of XRCC4.MLN4924 therapy as a novel approach in cancer treatment modalities.NEDD8-mediated neddylation is required for human endometrial stromal proliferation and decidualization.Neddylation E2 UBE2F Promotes the Survival of Lung Cancer Cells by Activating CRL5 to Degrade NOXA via the K11 Linkage.MLN4924 suppresses neddylation and induces cell cycle arrest, senescence, and apoptosis in human osteosarcomaPromoting tumorigenesis in nasopharyngeal carcinoma, NEDD8 serves as a potential theranostic target.NEDD8 and HDACs: promising cotargets in AML.SAG/RBX2 is a novel substrate of NEDD4-1 E3 ubiquitin ligase and mediates NEDD4-1 induced chemosensitization.A potent small-molecule inhibitor of the DCN1-UBC12 interaction that selectively blocks cullin 3 neddylationInhibition of neddylation facilitates cell migration through enhanced phosphorylation of caveolin-1 in PC3 and U373MG cells.Protein neddylation and its alterations in human cancers for targeted therapy.Neddylation inhibitor MLN4924 induces G2 cell cycle arrest, DNA damage and sensitizes esophageal squamous cell carcinoma cells to cisplatin.Regulation of Mammalian DNA Replication via the Ubiquitin-Proteasome System.The Nedd8-activating enzyme inhibitor MLN4924 suppresses colon cancer cell growth triggering autophagy
P2860
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P2860
Targeting Neddylation pathways to inactivate cullin-RING ligases for anticancer therapy
description
2014 nî lūn-bûn
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2014 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի փետրվարին հրատարակված գիտական հոդված
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2014年の論文
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2014年学术文章
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2014年学术文章
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2014年学术文章
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2014年学术文章
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2014年学术文章
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2014年學術文章
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name
Targeting Neddylation pathways to inactivate cullin-RING ligases for anticancer therapy
@ast
Targeting Neddylation pathways to inactivate cullin-RING ligases for anticancer therapy
@en
Targeting Neddylation pathways to inactivate cullin-RING ligases for anticancer therapy
@nl
type
label
Targeting Neddylation pathways to inactivate cullin-RING ligases for anticancer therapy
@ast
Targeting Neddylation pathways to inactivate cullin-RING ligases for anticancer therapy
@en
Targeting Neddylation pathways to inactivate cullin-RING ligases for anticancer therapy
@nl
prefLabel
Targeting Neddylation pathways to inactivate cullin-RING ligases for anticancer therapy
@ast
Targeting Neddylation pathways to inactivate cullin-RING ligases for anticancer therapy
@en
Targeting Neddylation pathways to inactivate cullin-RING ligases for anticancer therapy
@nl
P2093
P2860
P356
P1476
Targeting Neddylation pathways to inactivate cullin-RING ligases for anticancer therapy
@en
P2093
Meredith A Morgan
Yongchao Zhao
P2860
P304
P356
10.1089/ARS.2013.5795
P577
2014-02-20T00:00:00Z