Mislocalization of the E3 ligase, β-transducin repeat-containing protein 1 (β-TrCP1), in glioblastoma uncouples negative feedback between the pleckstrin homology domain leucine-rich repeat protein phosphatase 1 (PHLPP1) and Akt.
about
Turning off AKT: PHLPP as a drug targetSuppression of survival signalling pathways by the phosphatase PHLPPGiant obscurins regulate the PI3K cascade in breast epithelial cells via direct binding to the PI3K/p85 regulatory subunitSignaling specificity in the Akt pathway in biology and disease.Pleckstrin homology domain leucine-rich repeat protein phosphatases set the amplitude of receptor tyrosine kinase output.Contactin-1 reduces E-cadherin expression via activating AKT in lung cancer.Leukotriene-C4 synthase, a critical enzyme in the activation of store-independent Orai1/Orai3 channels, is required for neointimal hyperplasia.Expression of β-transducin repeat-containing E3 ubiquitin protein ligase in human glioma and its correlation with prognosis.Pleckstrin homology domain leucine-rich repeat protein phosphatase (PHLPP): a new player in cell signaling.PHLPP1 gene deletion protects the brain from ischemic injuryThe role of ubiquitin-proteasome system in glioma survival and growth.The cardioprotection of the insulin-mediated PI3K/Akt/mTOR signaling pathway.PHLPP phosphatases as a therapeutic target in insulin resistance-related diseases.PIM Kinase Inhibitors Kill Hypoxic Tumor Cells by Reducing Nrf2 Signaling and Increasing Reactive Oxygen Species.Oncogenic suppression of PHLPP1 in human melanoma.The deubiquitination enzyme USP46 functions as a tumor suppressor by controlling PHLPP-dependent attenuation of Akt signaling in colon cancer.PHLPP regulates hexokinase 2-dependent glucose metabolism in colon cancer cells.
P2860
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P2860
Mislocalization of the E3 ligase, β-transducin repeat-containing protein 1 (β-TrCP1), in glioblastoma uncouples negative feedback between the pleckstrin homology domain leucine-rich repeat protein phosphatase 1 (PHLPP1) and Akt.
description
2011 nî lūn-bûn
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2011 թուականի Մարտին հրատարակուած գիտական յօդուած
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2011 թվականի մարտին հրատարակված գիտական հոդված
@hy
2011年の論文
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2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Mislocalization of the E3 liga ...... hosphatase 1 (PHLPP1) and Akt.
@ast
Mislocalization of the E3 liga ...... hosphatase 1 (PHLPP1) and Akt.
@en
type
label
Mislocalization of the E3 liga ...... hosphatase 1 (PHLPP1) and Akt.
@ast
Mislocalization of the E3 liga ...... hosphatase 1 (PHLPP1) and Akt.
@en
prefLabel
Mislocalization of the E3 liga ...... hosphatase 1 (PHLPP1) and Akt.
@ast
Mislocalization of the E3 liga ...... hosphatase 1 (PHLPP1) and Akt.
@en
P2093
P2860
P50
P356
P1476
Mislocalization of the E3 liga ...... hosphatase 1 (PHLPP1) and Akt.
@en
P2093
Matt Niederst
Michael W Stevens
Paul M Brennan
P2860
P304
19777-19788
P356
10.1074/JBC.M111.237081
P407
P577
2011-03-28T00:00:00Z