Sterol-regulated degradation of Insig-1 mediated by the membrane-bound ubiquitin ligase gp78
about
Membrane-associated ubiquitin ligase complex containing gp78 mediates sterol-accelerated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductaseThe TRC8 ubiquitin ligase is sterol regulated and interacts with lipid and protein biosynthetic pathwaysPolyubiquitylation of AMF requires cooperation between the gp78 and TRIM25 ubiquitin ligasesAllosteric regulation of E2:E3 interactions promote a processive ubiquitination machineHECT and RING finger families of E3 ubiquitin ligases at a glanceDiversity of degradation signals in the ubiquitin-proteasome systemCholesterol feedback: from Schoenheimer's bottle to Scap's MELADLUnsaturated fatty acids inhibit proteasomal degradation of Insig-1 at a postubiquitination stepRING-type E3 ligases: master manipulators of E2 ubiquitin-conjugating enzymes and ubiquitinationUbiquitin ligases in cholesterol metabolismThe predator becomes the prey: regulating the ubiquitin system by ubiquitylation and degradationSterol Regulatory Element-Binding Proteins (SREBP) signallingSterol-induced dislocation of 3-hydroxy-3-methylglutaryl coenzyme A reductase from endoplasmic reticulum membranes into the cytosol through a subcellular compartment resembling lipid droplets.A novel polymorphism of the GP78 gene is associated with coronary artery disease in Han population in China.Targeting of gp78 for ubiquitin-mediated proteasomal degradation by Hrd1: cross-talk between E3s in the endoplasmic reticulum.The Unfolded Protein Response, Degradation from Endoplasmic Reticulum and CancerSterol-induced degradation of HMG CoA reductase depends on interplay of two Insigs and two ubiquitin ligases, gp78 and Trc8.Inhibition of apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodents.gp78 functions downstream of Hrd1 to promote degradation of misfolded proteins of the endoplasmic reticulumUbiquitin ligases, critical mediators of endoplasmic reticulum-associated degradationDifferential regulation of HMG-CoA reductase and Insig-1 by enzymes of the ubiquitin-proteasome system.Ancient ubiquitous protein-1 mediates sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl CoA reductase in lipid droplet-associated endoplasmic reticulum membranes.Insulin-induced gene protein (INSIG)-dependent sterol regulation of Hmg2 endoplasmic reticulum-associated degradation (ERAD) in yeast.Lipid-regulated degradation of HMG-CoA reductase and Insig-1 through distinct mechanisms in insect cells.Bax Inhibitor-1 regulates hepatic lipid accumulation via ApoB secretion.Breast cancer proteomics reveals correlation between estrogen receptor status and differential phosphorylation of PGRMC1.Autocrine motility factor receptor: a clinical review.A Ubc7p-binding domain in Cue1p activates ER-associated protein degradation.Feedback regulation of cholesterol synthesis: sterol-accelerated ubiquitination and degradation of HMG CoA reductase.Inability to fully suppress sterol synthesis rates with exogenous sterol in embryonic and extraembyronic fetal tissuesDegradation of sterol regulatory element-binding protein precursor requires the endoplasmic reticulum-associated degradation components Ubc7 and Hrd1 in fission yeastEvolutionary conservation and adaptation in the mechanism that regulates SREBP action: what a long, strange tRIP it's beenRegulated endoplasmic reticulum-associated degradation of a polytopic protein: p97 recruits proteasomes to Insig-1 before extraction from membranesIntramembrane glycine mediates multimerization of Insig-2, a requirement for sterol regulation in Chinese hamster ovary cells.Fatty acid-regulated transcription factors in the liver.The E3 ubiquitin ligase MARCH6 degrades squalene monooxygenase and affects 3-hydroxy-3-methyl-glutaryl coenzyme A reductase and the cholesterol synthesis pathway.Regulation of cholesterol and fatty acid synthesis.A pathway approach to investigate the function and regulation of SREBPs.Possible role of PGRMC1 in breast cancer development.The role and therapeutic implications of RING-finger E3 ubiquitin ligases in hepatocellular carcinoma.
P2860
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P2860
Sterol-regulated degradation of Insig-1 mediated by the membrane-bound ubiquitin ligase gp78
description
2006 nî lūn-bûn
@nan
2006 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
name
Sterol-regulated degradation o ...... ne-bound ubiquitin ligase gp78
@ast
Sterol-regulated degradation o ...... ne-bound ubiquitin ligase gp78
@en
Sterol-regulated degradation o ...... ne-bound ubiquitin ligase gp78
@en-gb
Sterol-regulated degradation o ...... ne-bound ubiquitin ligase gp78
@nl
type
label
Sterol-regulated degradation o ...... ne-bound ubiquitin ligase gp78
@ast
Sterol-regulated degradation o ...... ne-bound ubiquitin ligase gp78
@en
Sterol-regulated degradation o ...... ne-bound ubiquitin ligase gp78
@en-gb
Sterol-regulated degradation o ...... ne-bound ubiquitin ligase gp78
@nl
prefLabel
Sterol-regulated degradation o ...... ne-bound ubiquitin ligase gp78
@ast
Sterol-regulated degradation o ...... ne-bound ubiquitin ligase gp78
@en
Sterol-regulated degradation o ...... ne-bound ubiquitin ligase gp78
@en-gb
Sterol-regulated degradation o ...... ne-bound ubiquitin ligase gp78
@nl
P2093
P2860
P3181
P356
P1476
Sterol-regulated degradation o ...... ne-bound ubiquitin ligase gp78
@en
P2093
Baoliang Song
Joon No Lee
Russell A DeBose-Boyd
P2860
P304
P3181
P356
10.1074/JBC.M608999200
P407
P577
2006-12-22T00:00:00Z