Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes - Wikidata - wikimedia - TriplyDB

Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes

Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes

http://www.wikidata.org/entity/Q24683425

about

REV-ERBalpha participates in circadian SREBP signaling and bile acid homeostasis The TRC8 ubiquitin ligase is sterol regulated and interacts with lipid and protein biosynthetic pathways Degradation of the LDL receptors by PCSK9 is not mediated by a secreted protein acted upon by PCSK9 extracellularly The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: functional consequences of natural mutations and post-translational modifications Hepatic PCSK9 expression is regulated by nutritional status via insulin and sterol regulatory element-binding protein 1c Crystal structure of Spot 14, a modulator of fatty acid synthesis RING-dependent tumor suppression and G2/M arrest induced by the TRC8 hereditary kidney cancer gene Sterol-regulated degradation of Insig-1 mediated by the membrane-bound ubiquitin ligase gp78 SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice Subcellular localization and regulation of StarD4 protein in macrophages and fibroblasts Proteasomal degradation of ubiquitinated Insig proteins is determined by serine residues flanking ubiquitinated lysines Juxtamembranous aspartic acid in Insig-1 and Insig-2 is required for cholesterol homeostasis Adenoviral-mediated expression of Pcsk9 in mice results in a low-density lipoprotein receptor knockout phenotype The PCSK9 decade Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis STARD4 abundance regulates sterol transport and sensing Suppression of 2,3-oxidosqualene cyclase by high fat diet contributes to liver X receptor-alpha-mediated improvement of hepatic lipid profile Hepatocyte nuclear factor 1alpha plays a critical role in PCSK9 gene transcription and regulation by the natural hypocholesterolemic compound berberine Intracellular cholesterol transporter StarD4 binds free cholesterol and increases cholesteryl ester formation Unsaturated fatty acids inhibit proteasomal degradation of Insig-1 at a postubiquitination step Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Insig renders sorting signal in Scap inaccessible to COPII proteins Identifying transcriptional targets Cell-autonomous death of cerebellar purkinje neurons with autophagy in Niemann-Pick type C disease Differential gene expression in anatomical compartments of the human eye.Hypercholesterolemia, low density lipoprotein receptor and proprotein convertase subtilisin/kexin-type 9 Dual functions of Insig proteins in cholesterol homeostasis Nonalcoholic fatty liver disease: update on pathogenesis, diagnosis, treatment and the role of S-adenosylmethionine Diverse roles of SIRT1 in cancer biology and lipid metabolism Proprotein convertase subtilisin/kexin type 9: from the discovery to the development of new therapies for cardiovascular diseases Role of mitochondria in nonalcoholic fatty liver disease Influence of neonatal hypothyroidism on hepatic gene expression and lipid metabolism in adulthood Maternal nutrition induces pervasive gene expression changes but no detectable DNA methylation differences in the liver of adult offspring Trafficking Dynamics of PCSK9-Induced LDLR Degradation: Focus on Human PCSK9 Mutations and C-Terminal Domain Coordinately regulated alternative splicing of genes involved in cholesterol biosynthesis and uptake Epistasis of transcriptomes reveals synergism between transcriptional activators Hnf1alpha and Hnf4alpha Host-Specific Response to HCV Infection in the Chimeric SCID-beige/Alb-uPA Mouse Model: Role of the Innate Antiviral Immune Response Molecular biology of PCSK9: its role in LDL metabolism Antagonism of Secreted PCSK9 Increases Low Density Lipoprotein Receptor Expression in HepG2 Cells

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Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes

http://www.wikidata.org/entity/Q24683425

description

2003 nî lūn-bûn

@nan

2003 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2003 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2003年の論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年论文

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name

Combined analysis of oligonucl ...... fies direct SREBP target genes

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Combined analysis of oligonucl ...... fies direct SREBP target genes

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Combined analysis of oligonucl ...... fies direct SREBP target genes

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type

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Combined analysis of oligonucl ...... fies direct SREBP target genes

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Combined analysis of oligonucl ...... fies direct SREBP target genes

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Combined analysis of oligonucl ...... fies direct SREBP target genes

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prefLabel

Combined analysis of oligonucl ...... fies direct SREBP target genes

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Combined analysis of oligonucl ...... fies direct SREBP target genes

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Combined analysis of oligonucl ...... fies direct SREBP target genes

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PNAS.1534923100

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Proceedings of the National Academy of Sciences of the United States of America

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Combined analysis of oligonucl ...... fies direct SREBP target genes

@en

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Janet A Warrington

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Jay D Horton

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Michael S Brown

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Nila A Shah

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Norma N Anderson

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P2860

Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters

The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation

Characterization of mouse short-chain aldehyde reductase (SCALD), an enzyme regulated by sterol regulatory element-binding proteins

Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER

Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins

Sterol regulatory element-binding protein-2 interacts with hepatocyte nuclear factor-4 to enhance sterol isomerase gene expression in hepatocytes

The cholesterol-regulated StarD4 gene encodes a StAR-related lipid transfer protein with two closely related homologues, StarD5 and StarD6

Biliverdin reductase: a major physiologic cytoprotectant

Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta

Structure and lipid transport mechanism of a StAR-related domain

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12027-32

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913415

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10.1073/PNAS.1534923100

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21

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Joseph L. Goldstein

Sahng Wook Park

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2003-10-14T00:00:00Z

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9077065

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