SEL-10 interacts with presenilin 1, facilitates its ubiquitination, and alters A-beta peptide production
about
Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7Hacker within! Ehrlichia chaffeensis Effector Driven Phagocyte Reprogramming StrategyThe Ubiquitin-Proteasome System: Potential Therapeutic Targets for Alzheimer's Disease and Spinal Cord InjuryAn E3 ubiquitin ligase, Synoviolin, is involved in the degradation of immature nicastrin, and regulates the production of amyloid beta-proteinNovel subtractive transcription-based amplification of mRNA (STAR) method and its application in search of rare and differentially expressed genes in AD brains.The SV40 large T antigen contains a decoy phosphodegron that mediates its interactions with Fbw7/hCdc4.Mutations in genes involved in nonsense mediated decay ameliorate the phenotype of sel-12 mutants with amber stop mutations in Caenorhabditis elegansNeddylation dysfunction in Alzheimer's disease.Inactivation of FBXW7/hCDC4-β expression by promoter hypermethylation is associated with favorable prognosis in primary breast cancerAdaptive evolution in two large families of ubiquitin-ligase adapters in nematodes and plantsDying for a cause: invertebrate genetics takes on human neurodegeneration.Notch signaling is antagonized by SAO-1, a novel GYF-domain protein that interacts with the E3 ubiquitin ligase SEL-10 in Caenorhabditis elegansThe role of ubiquitin-protein ligases in neurodegenerative disease.The role of presenilin and its interacting proteins in the biogenesis of Alzheimer's beta amyloidThe ubiquitous nature of cancer: the role of the SCF(Fbw7) complex in development and transformationThe Caenorhabditis elegans F-box protein SEL-10 promotes female development and may target FEM-1 and FEM-3 for degradation by the proteasome.Understanding the molecular basis of Alzheimer's disease using a Caenorhabditis elegans model system.Cross-functional E3 ligases Parkin and C-terminus Hsp70-interacting protein in neurodegenerative disorders.E3 ubiquitin ligases in protein quality control mechanism.Ubiquitin pathways in neurodegenerative disease.Inhibition of γ-Secretase Leads to an Increase in Presenilin-1.Interleukin-1 receptor type 1 is a substrate for gamma-secretase-dependent regulated intramembrane proteolysis.Pen-2 is sequestered in the endoplasmic reticulum and subjected to ubiquitylation and proteasome-mediated degradation in the absence of presenilin.A ubiquitin-binding CUE domain in presenilin-1 enables interaction with K63-linked polyubiquitin chains.The favorable effect of activating NOTCH1 receptor mutations on long-term outcome in T-ALL patients treated on the ALL-BFM 2000 protocol can be separated from FBXW7 loss of function.Regulated intramembrane proteolysis: emergent role in cell signalling pathways.
P2860
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P2860
SEL-10 interacts with presenilin 1, facilitates its ubiquitination, and alters A-beta peptide production
description
2002 nî lūn-bûn
@nan
2002 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
SEL-10 interacts with presenil ...... ters A-beta peptide production
@ast
SEL-10 interacts with presenil ...... ters A-beta peptide production
@en
SEL-10 interacts with presenil ...... ters A-beta peptide production
@en-gb
SEL-10 interacts with presenil ...... ters A-beta peptide production
@nl
type
label
SEL-10 interacts with presenil ...... ters A-beta peptide production
@ast
SEL-10 interacts with presenil ...... ters A-beta peptide production
@en
SEL-10 interacts with presenil ...... ters A-beta peptide production
@en-gb
SEL-10 interacts with presenil ...... ters A-beta peptide production
@nl
prefLabel
SEL-10 interacts with presenil ...... ters A-beta peptide production
@ast
SEL-10 interacts with presenil ...... ters A-beta peptide production
@en
SEL-10 interacts with presenil ...... ters A-beta peptide production
@en-gb
SEL-10 interacts with presenil ...... ters A-beta peptide production
@nl
P2093
P2860
P921
P3181
P1476
SEL-10 interacts with presenil ...... ters A-beta peptide production
@en
P2093
Adele M Pauley
Allen E Buhl
Cara Ruble
John R Brashler
Mark E Gurney
Rick L Myers
Riqiang Yan
Rongqing Shuang
P2860
P304
P3181
P356
10.1046/J.1471-4159.2002.01105.X
P407
P577
2002-09-01T00:00:00Z