CD22 associates with protein tyrosine phosphatase 1C, Syk, and phospholipase C-gamma(1) upon B cell activation
about
The myeloid-specific sialic acid-binding receptor, CD33, associates with the protein-tyrosine phosphatases, SHP-1 and SHP-2Human 70-kDa SHP-1L differs from 68-kDa SHP-1 in its C-terminal structure and catalytic activityEngagement of p75/AIRM1 or CD33 inhibits the proliferation of normal or leukemic myeloid cellsIdentification and characterization of leukocyte-associated Ig-like receptor-1 as a major anchor protein of tyrosine phosphatase SHP-1 in hematopoietic cellsA novel phosphotyrosine motif with a critical amino acid at position -2 for the SH2 domain-mediated activation of the tyrosine phosphatase SHP-1SHP-1 binds and negatively modulates the c-Kit receptor by interaction with tyrosine 569 in the c-Kit juxtamembrane domain.A double-edged kinase Lyn: a positive and negative regulator for antigen receptor-mediated signalsInterference with immunoglobulin (Ig)alpha immunoreceptor tyrosine-based activation motif (ITAM) phosphorylation modulates or blocks B cell development, depending on the availability of an Igbeta cytoplasmic tailRethinking mechanisms of autoimmune pathogenesisCD22 forms a quaternary complex with SHIP, Grb2, and Shc. A pathway for regulation of B lymphocyte antigen receptor-induced calcium fluxCD22 regulates B cell receptor-mediated signals via two domains that independently recruit Grb2 and SHP-1CD22: an inhibitory enigmaCbl-mediated negative regulation of the Syk tyrosine kinase. A critical role for Cbl phosphotyrosine-binding domain binding to Syk phosphotyrosine 323Definition of the sites of interaction between the protein tyrosine phosphatase SHP-1 and CD22mSiglec-E, a novel mouse CD33-related siglec (sialic acid-binding immunoglobulin-like lectin) that recruits Src homology 2 (SH2)-domain-containing protein tyrosine phosphatases SHP-1 and SHP-2Analysis of tyrosine phosphorylation-dependent interactions between stimulatory effector proteins and the B cell co-receptor CD22Sequence specificity of SHP-1 and SHP-2 Src homology 2 domains. Critical roles of residues beyond the pY+3 position.Targeting CD22 with the monoclonal antibody epratuzumab modulates human B-cell maturation and cytokine production in response to Toll-like receptor 7 (TLR7) and B-cell receptor (BCR) signalingSubstrate specificity of protein tyrosine phosphatases 1B, RPTPĪ±, SHP-1, and SHP-2.CD22 EXON 12 deletion as a pathogenic mechanism of human B-precursor leukemiaNew functions for the sialic acid-binding adhesion molecule CD22, a member of the growing family of Siglecs.CD19, CD21, and CD22: multifaceted response regulators of B lymphocyte signal transduction.Isotype control of B cell signaling.Rapid T cell receptor-mediated SHP-1 S591 phosphorylation regulates SHP-1 cellular localization and phosphatase activityAbnormal chemokine-induced responses of immature and mature hematopoietic cells from motheaten mice implicate the protein tyrosine phosphatase SHP-1 in chemokine responses.Immune regulation by the ST6Gal sialyltransferase.Masking and unmasking of the sialic acid-binding lectin activity of CD22 (Siglec-2) on B lymphocytes.Nanoscale organization and dynamics of the siglec CD22 cooperate with the cytoskeleton in restraining BCR signalling.Antagonism or synergism. Role of tyrosine phosphatases SHP-1 and SHP-2 in growth factor signaling.CD22 is required for protection against West Nile virus Infection.CD19 and CD22 expression reciprocally regulates tyrosine phosphorylation of Vav protein during B lymphocyte signaling.Tonic B-cell and viral ITAM signaling: context is everything.Syk and pTyr'd: Signaling through the B cell antigen receptorRegulation of B-cell entry into the cell cycleDendritic cell-dependent inhibition of B cell proliferation requires CD22Mechanism and function of monoclonal antibodies targeting siglec-15 for therapeutic inhibition of osteoclastic bone resorption.Besides an ITIM/SHP-1-dependent pathway, CD22 collaborates with Grb2 and plasma membrane calcium-ATPase in an ITIM/SHP-1-independent pathway of attenuation of Ca2+i signal in B cells.CD22 and autoimmune disease.Stimulatory function of paired immunoglobulin-like receptor-A in mast cell line by associating with subunits common to Fc receptors.Promising Role of Toll-Like Receptor 8 Agonist in Concert with Prostratin for Activation of Silent HIV.
P2860
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P2860
CD22 associates with protein tyrosine phosphatase 1C, Syk, and phospholipase C-gamma(1) upon B cell activation
description
1996 nĆ® lÅ«n-bĆ»n
@nan
1996 Õ©ÕøÖÕ”ÕÆÕ”Õ¶Õ« ÕÕ„ÕæÖÕøÖÕ”ÖÕ«Õ¶ Õ°ÖÕ”ÕæÕ”ÖÕ”ÕÆÕøÖÕ”Õ® Õ£Õ«ÕæÕ”ÕÆÕ”Õ¶ ÕµÖ
Õ¤ÕøÖÕ”Õ®
@hyw
1996 Õ©Õ¾Õ”ÕÆÕ”Õ¶Õ« ÖÕ„ÕæÖÕ¾Õ”ÖÕ«Õ¶ Õ°ÖÕ”ÕæÕ”ÖÕ”ÕÆÕ¾Õ”Õ® Õ£Õ«ÕæÕ”ÕÆÕ”Õ¶ Õ°ÕøÕ¤Õ¾Õ”Õ®
@hy
1996幓ć®č«ę
@ja
1996幓č«ę
@yue
1996幓č«ę
@zh-hant
1996幓č«ę
@zh-hk
1996幓č«ę
@zh-mo
1996幓č«ę
@zh-tw
1996幓č®ŗę
@wuu
name
CD22 associates with protein t ...... amma(1) upon B cell activation
@ast
CD22 associates with protein t ...... amma(1) upon B cell activation
@en
CD22 associates with protein t ...... amma(1) upon B cell activation
@en-gb
CD22 associates with protein t ...... amma(1) upon B cell activation
@nl
type
label
CD22 associates with protein t ...... amma(1) upon B cell activation
@ast
CD22 associates with protein t ...... amma(1) upon B cell activation
@en
CD22 associates with protein t ...... amma(1) upon B cell activation
@en-gb
CD22 associates with protein t ...... amma(1) upon B cell activation
@nl
prefLabel
CD22 associates with protein t ...... amma(1) upon B cell activation
@ast
CD22 associates with protein t ...... amma(1) upon B cell activation
@en
CD22 associates with protein t ...... amma(1) upon B cell activation
@en-gb
CD22 associates with protein t ...... amma(1) upon B cell activation
@nl
P2093
P2860
P3181
P356
P1476
CD22 associates with protein t ...... amma(1) upon B cell activation
@en
P2093
P2860
P304
P3181
P356
10.1084/JEM.183.2.547
P407
P577
1996-02-01T00:00:00Z