Human immunodeficiency virus type 1 Nef and p56lck protein-tyrosine kinase interact with a common element in CD4 cytoplasmic tail - Wikidata - wikimedia - TriplyDB

Human immunodeficiency virus type 1 Nef and p56lck protein-tyrosine kinase interact with a common element in CD4 cytoplasmic tail

Human immunodeficiency virus type 1 Nef and p56lck protein-tyrosine kinase interact with a common element in CD4 cytoplasmic tail

http://www.wikidata.org/entity/Q24310700

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Mechanism for down-regulation of CD28 by Nef.Binding of c-Raf1 kinase to a conserved acidic sequence within the carboxyl-terminal region of the HIV-1 Nef protein Separable functions of Nef disrupt two aspects of T cell receptor machinery: CD4 expression and CD3 signaling Co-localization of HIV-1 Nef with the AP-2 adaptor protein complex correlates with Nef-induced CD4 down-regulation Mechanism of Nef-induced CD4 endocytosis: Nef connects CD4 with the mu chain of adaptor complexes.Nef-mediated clathrin-coated pit formation The pathogenicity of human immunodeficiency virus (HIV) type 1 Nef in CD4C/HIV transgenic mice is abolished by mutation of its SH3-binding domain, and disease development is delayed in the absence of Hck.The SH3 domain-binding surface and an acidic motif in HIV-1 Nef regulate trafficking of class I MHC complexes.Refined solution structure and backbone dynamics of HIV-1 Nef.Dissociation of the CD4 downregulation and viral infectivity enhancement functions of human immunodeficiency virus type 1 Nef.Molecular and cellular analysis of human immunodeficiency virus-induced apoptosis in lymphoblastoid T-cell-line-expressing wild-type and mutated CD4 receptors Simian and human immunodeficiency virus Nef proteins use different surfaces to downregulate class I major histocompatibility complex antigen expression.Adenovirus RIDbeta subunit contains a tyrosine residue that is critical for RID-mediated receptor internalization and inhibition of Fas- and TRAIL-induced apoptosis Mechanistic aspects of HIV-1 reverse transcription initiation.Cooperative interactions of simian immunodeficiency virus Nef, AP-2, and CD3-zeta mediate the selective induction of T-cell receptor-CD3 endocytosis.Inhibition of Nef- and phorbol ester-induced CD4 degradation by macrolide antibiotics.High frequency of defective nef alleles in a long-term survivor with nonprogressive human immunodeficiency virus type 1 infection.Human immunodeficiency virus types 1 and 2 and simian immunodeficiency virus Nef use distinct but overlapping target sites for downregulation of cell surface CD4.HIV-induced apoptosis requires the CD4 receptor cytoplasmic tail and is accelerated by interaction of CD4 with p56lck.HIV accessory proteins: emerging therapeutic targets.Binding of human immunodeficiency virus type 1 to CD4 induces association of Lck and Raf-1 and activates Raf-1 by a Ras-independent pathway Nef can enhance the infectivity of receptor-pseudotyped human immunodeficiency virus type 1 particles.CD4 receptor localized to non-raft membrane microdomains supports HIV-1 entry. Identification of a novel raft localization marker in CD4.HIV-1 Nef: Taking Control of Protein Trafficking.HIV-1 Nef and T-cell activation: a history of contradictions.Direct in vitro binding of full-length human immunodeficiency virus type 1 Nef protein to CD4 cytoplasmic domain.Nef-induced CD4 endocytosis in human immunodeficiency virus type 1 host cells: role of p56lck kinase.Functional characterization of human immunodeficiency virus type 1 nef genes in patients with divergent rates of disease progression.Downregulation of gamma interferon receptor 1 by Kaposi's sarcoma-associated herpesvirus K3 and K5.The effects of HIV-1 Nef on CD4 surface expression and viral infectivity in lymphoid cells are independent of rafts.Hyper-responsiveness to stimulation of human immunodeficiency virus-infected CD4+ T cells requires Nef and Tat virus gene products and results from higher NFAT, NF-kappaB, and AP-1 induction.Nef Mediated CD4 Down-regulation HTLV-1 Tax is a critical lipid raft modulator that hijacks IkappaB kinases to the microdomains for persistent activation of NF-kappaB.

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Human immunodeficiency virus type 1 Nef and p56lck protein-tyrosine kinase interact with a common element in CD4 cytoplasmic tail

http://www.wikidata.org/entity/Q24310700

description

1995 nî lūn-bûn

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1995 թուականի Յունուարին հրատարակուած գիտական յօդուած

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1995 թվականի հունվարին հրատարակված գիտական հոդված

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1995年の論文

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1995年論文

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1995年論文

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1995年論文

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1995年論文

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1995年論文

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Human immunodeficiency virus t ...... lement in CD4 cytoplasmic tail

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Human immunodeficiency virus t ...... lement in CD4 cytoplasmic tail

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Human immunodeficiency virus t ...... lement in CD4 cytoplasmic tail

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Human immunodeficiency virus t ...... lement in CD4 cytoplasmic tail

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Human immunodeficiency virus t ...... lement in CD4 cytoplasmic tail

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Proceedings of the National Academy of Sciences of the United States of America

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Human immunodeficiency virus t ...... lement in CD4 cytoplasmic tail

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J Skowronski

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R Mariani

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S Salghetti

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P2860

Serine phosphorylation-independent downregulation of cell-surface CD4 by nef

Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain

Phosphatidylinositol (PI) 3-kinase and PI 4-kinase binding to the CD4-p56lck complex: the p56lck SH3 domain binds to PI 3-kinase but not PI 4-kinase

The CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytes

A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chains

Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting.

The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

Importance of the nef gene for maintenance of high virus loads and for development of AIDS

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349-53

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scholarly article

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10.1073/PNAS.92.2.349

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2

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92

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1995-01-17T00:00:00Z

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7831289

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42737

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