Identification, cloning, and characterization of a novel human T-cell-specific tyrosine kinase located at the hematopoietin complex on chromosome 5q
about
p56Lck and p59Fyn regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor-bound protein GRB-2, and T cell-specific protein-tyrosine kinase ITK: implications for T-cell costimulationTyrosine phosphorylation and activation of Bruton tyrosine kinase upon Fc epsilon RI cross-linkingFunctional analysis of the T-cell-restricted protein tyrosine kinase Txk.Src family protein tyrosine kinases induce autoactivation of Bruton's tyrosine kinase.CD28 is associated with and induces the immediate tyrosine phosphorylation and activation of the Tec family kinase ITK/EMT in the human Jurkat leukemic T-cell line.T-cell signaling regulated by the Tec family kinase, Itk.Disrupting the intermolecular self-association of Itk enhances T cell signaling.Itk: the rheostat of the T cell response.Unusual patterns of exon skipping in Bruton tyrosine kinase are associated with mutations involving the intron 17 3' splice site.Antiviral immune responses in Itk-deficient mice.Itk negatively regulates induction of T cell proliferation by CD28 costimulation.Involvement of Bruton's tyrosine kinase in FcepsilonRI-dependent mast cell degranulation and cytokine production.Src-induced activation of inducible T cell kinase (ITK) requires phosphatidylinositol 3-kinase activity and the Pleckstrin homology domain of inducible T cell kinaseGirls homozygous for an IL-2-inducible T cell kinase mutation that leads to protein deficiency develop fatal EBV-associated lymphoproliferation.Itk tyrosine kinase substrate docking is mediated by a nonclassical SH2 domain surface of PLCgamma1.Targeting Interleukin-2-Inducible T-cell Kinase (ITK) in T-Cell Related Diseases.ITK inhibitors in inflammation and immune-mediated disorders.Efficient CD28 signalling leads to increases in the kinase activities of the TEC family tyrosine kinase EMT/ITK/TSK and the SRC family tyrosine kinase LCK.
P2860
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P2860
Identification, cloning, and characterization of a novel human T-cell-specific tyrosine kinase located at the hematopoietin complex on chromosome 5q
description
1993 nî lūn-bûn
@nan
1993 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
name
Identification, cloning, and c ...... ietin complex on chromosome 5q
@ast
Identification, cloning, and c ...... ietin complex on chromosome 5q
@en
Identification, cloning, and c ...... ietin complex on chromosome 5q
@en-gb
Identification, cloning, and c ...... ietin complex on chromosome 5q
@nl
type
label
Identification, cloning, and c ...... ietin complex on chromosome 5q
@ast
Identification, cloning, and c ...... ietin complex on chromosome 5q
@en
Identification, cloning, and c ...... ietin complex on chromosome 5q
@en-gb
Identification, cloning, and c ...... ietin complex on chromosome 5q
@nl
prefLabel
Identification, cloning, and c ...... ietin complex on chromosome 5q
@ast
Identification, cloning, and c ...... ietin complex on chromosome 5q
@en
Identification, cloning, and c ...... ietin complex on chromosome 5q
@en-gb
Identification, cloning, and c ...... ietin complex on chromosome 5q
@nl
P2093
P1433
P1476
Identification, cloning, and c ...... ietin complex on chromosome 5q
@en
P2093
P304
P407
P577
1993-09-01T00:00:00Z