Itk tyrosine kinase substrate docking is mediated by a nonclassical SH2 domain surface of PLCgamma1.
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Sequential phosphorylation of SLP-76 at tyrosine 173 is required for activation of T and mast cellsStructural Basis for the Interaction between the Growth Factor-binding Protein GRB10 and the E3 Ubiquitin Ligase NEDD4Two Closely Spaced Tyrosines Regulate NFAT Signaling in B Cells via Syk Association with VavThe language of SH2 domain interactions defines phosphotyrosine-mediated signal transductionLKB1 regulates TCR-mediated PLCγ1 activation and thymocyte positive selectionSH2 Domains Recognize Contextual Peptide Sequence Information to Determine SelectivityLAT-independent Erk activation via Bam32-PLC-γ1-Pak1 complexes: GTPase-independent Pak1 activation.Activation loop dynamics determine the different catalytic efficiencies of B cell- and T cell-specific tec kinases.T-cell signaling regulated by the Tec family kinase, Itk.Identification of an allosteric signaling network within Tec family kinases.Lipid signaling in T-cell development and functionAlkylglycerols modulate the proliferation and differentiation of non-specific agonist and specific antigen-stimulated splenic lymphocytesScaffold Protein SLP-76 Primes PLCγ1 for Activation by ITK-Mediated Phosphorylation.DEF6, a novel substrate for the Tec kinase ITK, contains a glutamine-rich aggregation-prone region and forms cytoplasmic granules that co-localize with P-bodies.Phosphotyrosine recognition domains: the typical, the atypical and the versatile.Signaling by Fyn-ADAP via the Carma1-Bcl-10-MAP3K7 signalosome exclusively regulates inflammatory cytokine production in NK cells.Substrate recognition of PLCγ1 via a specific docking surface on Itk.A measured approach: determining the PLCγ1 docking site on Itk using a biochemical ruler.
P2860
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P2860
Itk tyrosine kinase substrate docking is mediated by a nonclassical SH2 domain surface of PLCgamma1.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on December 2009
@en
vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Itk tyrosine kinase substrate ...... 2 domain surface of PLCgamma1.
@en
Itk tyrosine kinase substrate ...... 2 domain surface of PLCgamma1.
@nl
type
label
Itk tyrosine kinase substrate ...... 2 domain surface of PLCgamma1.
@en
Itk tyrosine kinase substrate ...... 2 domain surface of PLCgamma1.
@nl
prefLabel
Itk tyrosine kinase substrate ...... 2 domain surface of PLCgamma1.
@en
Itk tyrosine kinase substrate ...... 2 domain surface of PLCgamma1.
@nl
P2093
P2860
P356
P1476
Itk tyrosine kinase substrate ...... 2 domain surface of PLCgamma1.
@en
P2093
Amy H Andreotti
D Bruce Fulton
Raji E Joseph
P2860
P304
21143-21148
P356
10.1073/PNAS.0911309106
P407
P577
2009-12-01T00:00:00Z