Regulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1
about
ZFP100, a component of the active U7 snRNP limiting for histone pre-mRNA processing, is required for entry into S phaseBinding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decayDegradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'Upf1 ATPase-dependent mRNP disassembly is required for completion of nonsense- mediated mRNA decayKnockdown of SLBP results in nuclear retention of histone mRNASMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decayA competition between stimulators and antagonists of Upf complex recruitment governs human nonsense-mediated mRNA decayConserved zinc fingers mediate multiple functions of ZFP100, a U7snRNP associated proteinU7 snRNA mutations in Drosophila block histone pre-mRNA processing and disrupt oogenesisNew ways to meet your (3') end oligouridylation as a step on the path to destructionGenome-wide analysis of mRNAs bound to the histone stem-loop binding proteinMechanism and regulation of the nonsense-mediated decay pathwayProteins involved in the degradation of cytoplasmic mRNA in the major eukaryotic model systemsStructural and functional insights into the human Upf1 helicase coreNonsense-Mediated mRNA Decay: Degradation of Defective Transcripts Is Only Part of the StoryModelling Robust Feedback Control Mechanisms That Ensure Reliable Coordination of Histone Gene Expression with DNA ReplicationThe prolyl isomerase Pin1 targets stem-loop binding protein (SLBP) to dissociate the SLBP-histone mRNA complex linking histone mRNA decay with SLBP ubiquitinationLoss of the histone pre-mRNA processing factor stem-loop binding protein in Drosophila causes genomic instability and impaired cellular proliferationIn Silico Analysis of the Structural and Biochemical Features of the NMD Factor UPF1 in Ustilago maydisLarge-scale evidence for conservation of NMD candidature across mammals.Expression proteomics of UPF1 knockdown in HeLa cells reveals autoregulation of hnRNP A2/B1 mediated by alternative splicing resulting in nonsense-mediated mRNA decay.Stress-sensitive regulation of IFRD1 mRNA decay is mediated by an upstream open reading frameThe mRNP remodeling mediated by UPF1 promotes rapid degradation of replication-dependent histone mRNA.The code within the code: microRNAs target coding regions.More forks on the road to replication stress recoveryThe regulation of mRNA stability in mammalian cells: 2.0.Unexpected roles for UPF1 in HIV-1 RNA metabolism and translation.RNA homeostasis governed by cell type-specific and branched feedback loops acting on NMD.Dhx34 and Nbas function in the NMD pathway and are required for embryonic development in zebrafish.Genetic and biochemical characterization of Drosophila Snipper: A promiscuous member of the metazoan 3'hExo/ERI-1 family of 3' to 5' exonucleases.Analysis of RNA decay factor mediated RNA stability contributions on RNA abundance.Glucocorticoid receptor interacts with PNRC2 in a ligand-dependent manner to recruit UPF1 for rapid mRNA degradation.A novel role for hSMG-1 in stress granule formationAutoregulation of the nonsense-mediated mRNA decay pathway in human cellsN- and C-terminal Upf1 phosphorylations create binding platforms for SMG-6 and SMG-5:SMG-7 during NMDMechanistic insights and identification of two novel factors in the C. elegans NMD pathway.The abundance of RNPS1, a protein component of the exon junction complex, can determine the variability in efficiency of the Nonsense Mediated Decay pathwayCaenorhabditis elegans SMG-2 selectively marks mRNAs containing premature translation termination codons.Regulation of cytoplasmic mRNA decay.INT6 interacts with MIF4GD/SLIP1 and is necessary for efficient histone mRNA translation.
P2860
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P2860
Regulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1
description
2005 nî lūn-bûn
@nan
2005 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Regulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1
@ast
Regulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1
@en
Regulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1
@en-gb
Regulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1
@nl
type
label
Regulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1
@ast
Regulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1
@en
Regulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1
@en-gb
Regulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1
@nl
prefLabel
Regulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1
@ast
Regulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1
@en
Regulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1
@en-gb
Regulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1
@nl
P2860
P921
P3181
P356
P1476
Regulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1
@en
P2093
Handan Kaygun
William F Marzluff
P2860
P2888
P304
P3181
P356
10.1038/NSMB972
P407
P577
2005-09-01T00:00:00Z
P6179
1050624208