N- and C-terminal Upf1 phosphorylations create binding platforms for SMG-6 and SMG-5:SMG-7 during NMD - Wikidata - wikimedia - TriplyDB

N- and C-terminal Upf1 phosphorylations create binding platforms for SMG-6 and SMG-5:SMG-7 during NMD

N- and C-terminal Upf1 phosphorylations create binding platforms for SMG-6 and SMG-5:SMG-7 during NMD

http://www.wikidata.org/entity/Q35740527

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An unusual arrangement of two 14-3-3-like domains in the SMG5-SMG7 heterodimer is required for efficient nonsense-mediated mRNA decay Ribosome-based quality control of mRNA and nascent peptides Nonsense-mediated mRNA decay: novel mechanistic insights and biological impact Mechanism and regulation of the nonsense-mediated decay pathway The dharma of nonsense-mediated mRNA decay in mammalian cells Nonsense-mediated mRNA decay: inter-individual variability and human disease Structural and functional analysis of the three MIF4G domains of nonsense-mediated decay factor UPF2 Phospho-dependent and phospho-independent interactions of the helicase UPF1 with the NMD factors SMG5–SMG7 and SMG6 Nonsense-mediated mRNA decay in humans at a glance Nonsense-Mediated mRNA Decay: Degradation of Defective Transcripts Is Only Part of the Story Organizing principles of mammalian nonsense-mediated mRNA decay Attenuation of nonsense-mediated mRNA decay enhances in vivo nonsense suppression Mutations in SMG9, Encoding an Essential Component of Nonsense-Mediated Decay Machinery, Cause a Multiple Congenital Anomaly Syndrome in Humans and Mice In Silico Analysis of the Structural and Biochemical Features of the NMD Factor UPF1 in Ustilago maydis HIV-1 Recruits UPF1 but Excludes UPF2 to Promote Nucleocytoplasmic Export of the Genomic RNA.High-resolution profiling of NMD targets in yeast reveals translational fidelity as a basis for substrate selection.Identification and characterization of small molecules that inhibit nonsense-mediated RNA decay and suppress nonsense p53 mutations Multifaceted Regulation of Gene Expression by the Apoptosis- and Splicing-Associated Protein Complex and Its Components.A novel phosphorylation-independent interaction between SMG6 and UPF1 is essential for human NMD.A post-translational regulatory switch on UPF1 controls targeted mRNA degradation Emerging roles for ribonucleoprotein modification and remodeling in controlling RNA fate The interaction of cytoplasmic poly(A)-binding protein with eukaryotic initiation factor 4G suppresses nonsense-mediated mRNA decay.5-azacytidine inhibits nonsense-mediated decay in a MYC-dependent fashion.Human nonsense-mediated RNA decay initiates widely by endonucleolysis and targets snoRNA host genes.Nonsense-mediated decay in genetic disease: friend or foe?MARVELD1 Inhibits Nonsense-Mediated RNA Decay by Repressing Serine Phosphorylation of UPF1.Identification of SMG6 cleavage sites and a preferred RNA cleavage motif by global analysis of endogenous NMD targets in human cells.SMG6 cleavage generates metastable decay intermediates from nonsense-containing β-globin mRNA.Structural basis for regulation of RNA-binding proteins by phosphorylation.Attenuation of nonsense-mediated mRNA decay facilitates the response to chemotherapeutics.Regulation of cytoplasmic mRNA decay.A network of SMG-8, SMG-9 and SMG-1 C-terminal insertion domain regulates UPF1 substrate recruitment and phosphorylation Long noncoding RNA turnover.MicroRNA 433 regulates nonsense-mediated mRNA decay by targeting SMG5 mRNA.Drosophila mutants show NMD pathway activity is reduced, but not eliminated, in the absence of Smg6 A system for coordinated analysis of translational readthrough and nonsense-mediated mRNA decay.Nonsense-mediated mRNA decay in Tetrahymena is EJC independent and requires a protozoa-specific nuclease Target Discrimination in Nonsense-Mediated mRNA Decay Requires Upf1 ATPase Activity Recent transcriptome-wide mapping of UPF1 binding sites reveals evidence for its recruitment to mRNA before translation.SMG5-PNRC2 is functionally dominant compared with SMG5-SMG7 in mammalian nonsense-mediated mRNA decay.

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P2860

N- and C-terminal Upf1 phosphorylations create binding platforms for SMG-6 and SMG-5:SMG-7 during NMD

http://www.wikidata.org/entity/Q35740527

description

2011 nî lūn-bûn

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

N- and C-terminal Upf1 phospho ...... G-6 and SMG-5:SMG-7 during NMD

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N- and C-terminal Upf1 phospho ...... G-6 and SMG-5:SMG-7 during NMD

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type

label

N- and C-terminal Upf1 phospho ...... G-6 and SMG-5:SMG-7 during NMD

@ast

N- and C-terminal Upf1 phospho ...... G-6 and SMG-5:SMG-7 during NMD

@en

prefLabel

N- and C-terminal Upf1 phospho ...... G-6 and SMG-5:SMG-7 during NMD

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N- and C-terminal Upf1 phospho ...... G-6 and SMG-5:SMG-7 during NMD

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Nucleic Acids Research

P1476

N- and C-terminal Upf1 phospho ...... G-6 and SMG-5:SMG-7 during NMD

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P2093

Akio Yamashita

http://www.w3.org/2001/XMLSchema#string

Fumiki Hirahara

http://www.w3.org/2001/XMLSchema#string

Kei Kutsuzawa

http://www.w3.org/2001/XMLSchema#string

Natsuko Izumi

http://www.w3.org/2001/XMLSchema#string

Yukiko Okada-Katsuhata

http://www.w3.org/2001/XMLSchema#string

P2860

Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay

Evidence for a pioneer round of mRNA translation: mRNAs subject to nonsense-mediated decay in mammalian cells are bound by CBP80 and CBP20

Characterization of human Smg5/7a: a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1.

Failsafe nonsense-mediated mRNA decay does not detectably target eIF4E-bound mRNA

SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway

Characterization of SMG-9, an essential component of the nonsense-mediated mRNA decay SMG1C complex

Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7

SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay

Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay

The human RNA surveillance factor UPF1 is required for S phase progression and genome stability

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10.1093/NAR/GKR791

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P433

3

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40

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2011-09-29T00:00:00Z

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51686861

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21965535

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3273798

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