Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7
about
DHX34 and NBAS form part of an autoregulatory NMD circuit that regulates endogenous RNA targets in human cells, zebrafish and Caenorhabditis elegansSMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decayLocalization of nucleoporin Tpr to the nuclear pore complex is essential for Tpr mediated regulation of the export of unspliced RNA.Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decaySMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoanAn unusual arrangement of two 14-3-3-like domains in the SMG5-SMG7 heterodimer is required for efficient nonsense-mediated mRNA decayInteractions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathwaysRegulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1Upf1 ATPase-dependent mRNP disassembly is required for completion of nonsense- mediated mRNA decayFunctions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and translationSMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decayUpf1 phosphorylation triggers translational repression during nonsense-mediated mRNA decayUnusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2Histone deacetylase 8 safeguards the human ever-shorter telomeres 1B (hEST1B) protein from ubiquitin-mediated degradationStructures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complexSuppression of nonsense-mediated mRNA decay permits unbiased gene trapping in mouse embryonic stem cellsNonsense-mediated mRNA decay: novel mechanistic insights and biological impactThe dharma of nonsense-mediated mRNA decay in mammalian cellsNonsense-mediated mRNA decay: inter-individual variability and human diseaseThe Chp1–Tas3 core is a multifunctional platform critical for gene silencing by RITSPhospho-dependent and phospho-independent interactions of the helicase UPF1 with the NMD factors SMG5–SMG7 and SMG6Saccharomyces cerevisiae Ebs1p is a putative ortholog of human Smg7 and promotes nonsense-mediated mRNA decay.Role for Upf2p phosphorylation in Saccharomyces cerevisiae nonsense-mediated mRNA decay.Upf1 potentially serves as a RING-related E3 ubiquitin ligase via its association with Upf3 in yeastNonsense-mediated mRNA decay in humans at a glanceNonsense-Mediated mRNA Decay: Degradation of Defective Transcripts Is Only Part of the StoryProtein RNA and protein protein interactions mediate association of human EST1A/SMG6 with telomeraseOrganizing principles of mammalian nonsense-mediated mRNA decayAttenuation of nonsense-mediated mRNA decay enhances in vivo nonsense suppressionMutations in SMG9, Encoding an Essential Component of Nonsense-Mediated Decay Machinery, Cause a Multiple Congenital Anomaly Syndrome in Humans and MiceQuantitative phosphoproteomics analysis of nitric oxide-responsive phosphoproteins in cotton leafIn Silico Analysis of the Structural and Biochemical Features of the NMD Factor UPF1 in Ustilago maydisThe TPR-containing domain within Est1 homologs exhibits species-specific roles in telomerase interaction and telomere length homeostasisInhibition of Nonsense-mediated mRNA Decay by the Natural Product Pateamine A through Eukaryotic Initiation Factor 4AIIIHIV-1 Recruits UPF1 but Excludes UPF2 to Promote Nucleocytoplasmic Export of the Genomic RNA.Evolutionarily conserved protein ERH controls CENP-E mRNA splicing and is required for the survival of KRAS mutant cancer cellsNonsense-mediated mRNA decay impacts MSI-driven carcinogenesis and anti-tumor immunity in colorectal cancers.Mutations in genes involved in nonsense mediated decay ameliorate the phenotype of sel-12 mutants with amber stop mutations in Caenorhabditis elegansKinome siRNA screen identifies SMG-1 as a negative regulator of hypoxia-inducible factor-1alpha in hypoxiaModulation of nonsense mediated decay by rapamycin
P2860
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P248
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P2860
Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7
description
2003 nî lūn-bûn
@nan
2003 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Phosphorylation of hUPF1 induc ...... s containing hSMG-5 and hSMG-7
@ast
Phosphorylation of hUPF1 induc ...... s containing hSMG-5 and hSMG-7
@en
Phosphorylation of hUPF1 induc ...... s containing hSMG-5 and hSMG-7
@en-gb
Phosphorylation of hUPF1 induc ...... s containing hSMG-5 and hSMG-7
@nl
type
label
Phosphorylation of hUPF1 induc ...... s containing hSMG-5 and hSMG-7
@ast
Phosphorylation of hUPF1 induc ...... s containing hSMG-5 and hSMG-7
@en
Phosphorylation of hUPF1 induc ...... s containing hSMG-5 and hSMG-7
@en-gb
Phosphorylation of hUPF1 induc ...... s containing hSMG-5 and hSMG-7
@nl
prefLabel
Phosphorylation of hUPF1 induc ...... s containing hSMG-5 and hSMG-7
@ast
Phosphorylation of hUPF1 induc ...... s containing hSMG-5 and hSMG-7
@en
Phosphorylation of hUPF1 induc ...... s containing hSMG-5 and hSMG-7
@en-gb
Phosphorylation of hUPF1 induc ...... s containing hSMG-5 and hSMG-7
@nl
P2093
P50
P921
P3181
P1433
P1476
Phosphorylation of hUPF1 induc ...... s containing hSMG-5 and hSMG-7
@en
P2093
Akio Yamashita
Andrew Grimson
Isao Kashima
Philip Anderson
Takahisa Hachiya
Tetsuo Ohnishi
Thomas Schell
P304
P3181
P356
10.1016/S1097-2765(03)00443-X
P407
P577
2003-11-01T00:00:00Z