Crystal structure of alanine:glyoxylate aminotransferase and the relationship between genotype and enzymatic phenotype in primary hyperoxaluria type 1
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Human alanine-glyoxylate aminotransferase 2 lowers asymmetric dimethylarginine and protects from inhibition of nitric oxide productionMolecular defects of the glycine 41 variants of alanine glyoxylate aminotransferase associated with primary hyperoxaluria type IPeroxisomal import of human alanine:glyoxylate aminotransferase requires ancillary targeting information remote from its C terminusHuman wild-type alanine:glyoxylate aminotransferase and its naturally occurring G82E variant: functional properties and physiological implicationsCrystal structure of Homo sapiens kynureninaseCrystal structure of pyridoxamine-pyruvate aminotransferase from Mesorhizobium loti MAFF303099Structural implications of a G170R mutation of alanine:glyoxylate aminotransferase that is associated with peroxisome-to-mitochondrion mistargetingCrystal structure of the S187F variant of human liver alanine: Aminotransferase associated with primary hyperoxaluria type I and its functional implicationsMolecular Requirements for Peroxisomal Targeting of Alanine-Glyoxylate Aminotransferase as an Essential Determinant in Primary Hyperoxaluria Type 1The Role of Protein Denaturation Energetics and Molecular Chaperones in the Aggregation and Mistargeting of Mutants Causing Primary Hyperoxaluria Type ICrystal structure and substrate specificity of the thermophilic serine:pyruvate aminotransferase from Sulfolobus solfataricusThe consensus-based approach for gene/enzyme replacement therapies and crystallization strategies: the case of human alanine-glyoxylate aminotransferaseMolecular etiology of primary hyperoxaluria type 1: new directions for treatmentCellular transfection to deliver alanine-glyoxylate aminotransferase to hepatocytes: a rational gene therapy for primary hyperoxaluria-1 (PH-1).Mutational analysis of AGXT in two Chinese families with primary hyperoxaluria type 1.S81L and G170R mutations causing Primary Hyperoxaluria type I in homozygosis and heterozygosis: an example of positive interallelic complementation.Crystal structure of the Anopheles gambiae 3-hydroxykynurenine transaminasePerformance evaluation of Sanger sequencing for the diagnosis of primary hyperoxaluria and comparison with targeted next generation sequencingPrimary hyperoxaluria.Allele-specific characterization of alanine: glyoxylate aminotransferase variants associated with primary hyperoxaluriaRapid profiling of disease alleles using a tunable reporter of protein misfolding.Four of the most common mutations in primary hyperoxaluria type 1 unmask the cryptic mitochondrial targeting sequence of alanine:glyoxylate aminotransferase encoded by the polymorphic minor allele.Hyperoxaluria and systemic oxalosis: current therapy and future directions.Genome-wide association study of L-arginine and dimethylarginines reveals novel metabolic pathway for symmetric dimethylarginine.Two novel AGXT mutations identified in primary hyperoxaluria type-1 and distinct morphological and structural difference in kidney stonesProtein homeostasis defects of alanine-glyoxylate aminotransferase: new therapeutic strategies in primary hyperoxaluria type I.A novel mutation in the AGXT gene causing primary hyperoxaluria type I: genotype-phenotype correlation.Role of low native state kinetic stability and interaction of partially unfolded states with molecular chaperones in the mitochondrial protein mistargeting associated with primary hyperoxaluria.Biochemical analyses are instrumental in identifying the impact of mutations on holo and/or apo-forms and on the region(s) of alanine:glyoxylate aminotransferase variants associated with primary hyperoxaluria type I.Molecular cloning, expression and characterization of pyridoxamine-pyruvate aminotransferaseRadiation damage at the active site of human alanine:glyoxylate aminotransferase reveals that the cofactor position is finely tuned during catalysisIdentification of compound heterozygous patients with primary hyperoxaluria type 1: clinical evaluations and in silico investigationsIn vivo and in vitro examination of stability of primary hyperoxaluria-associated human alanine:glyoxylate aminotransferase.Molecular Insight into the Synergism between the Minor Allele of Human Liver Peroxisomal Alanine:Glyoxylate Aminotransferase and the F152I MutationEvolution of two alanine glyoxylate aminotransferases in mosquito.Structure of GroEL in complex with an early folding intermediate of alanine glyoxylate aminotransferase.Crystal structures of Aedes aegypti alanine glyoxylate aminotransferase.Recombinant production of eight human cytosolic aminotransferases and assessment of their potential involvement in glyoxylate metabolism.Mutational Analysis of Agxt in Tunisian Population with Primary Hyperoxaluria Type 1.A 20-year experience of combined liver/kidney transplantation for primary hyperoxaluria (PH1): the European PH1 transplant registry experience 1984-2004.
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P2860
Crystal structure of alanine:glyoxylate aminotransferase and the relationship between genotype and enzymatic phenotype in primary hyperoxaluria type 1
description
2003 nî lūn-bûn
@nan
2003 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Crystal structure of alanine:g ...... n primary hyperoxaluria type 1
@ast
Crystal structure of alanine:g ...... n primary hyperoxaluria type 1
@en
Crystal structure of alanine:g ...... n primary hyperoxaluria type 1
@en-gb
Crystal structure of alanine:g ...... n primary hyperoxaluria type 1
@nl
type
label
Crystal structure of alanine:g ...... n primary hyperoxaluria type 1
@ast
Crystal structure of alanine:g ...... n primary hyperoxaluria type 1
@en
Crystal structure of alanine:g ...... n primary hyperoxaluria type 1
@en-gb
Crystal structure of alanine:g ...... n primary hyperoxaluria type 1
@nl
prefLabel
Crystal structure of alanine:g ...... n primary hyperoxaluria type 1
@ast
Crystal structure of alanine:g ...... n primary hyperoxaluria type 1
@en
Crystal structure of alanine:g ...... n primary hyperoxaluria type 1
@en-gb
Crystal structure of alanine:g ...... n primary hyperoxaluria type 1
@nl
P2093
P921
P3181
P1476
Crystal structure of alanine:g ...... n primary hyperoxaluria type 1
@en
P2093
Christopher J Danpure
Laurence H Pearl
S Mark Roe
Xiaoxuan Zhang
Yanwen Hou
P304
P3181
P356
10.1016/S0022-2836(03)00791-5
P407
P50
P577
2003-08-15T00:00:00Z