Human wild-type alanine:glyoxylate aminotransferase and its naturally occurring G82E variant: functional properties and physiological implications - Wikidata - wikimedia - TriplyDB

Human wild-type alanine:glyoxylate aminotransferase and its naturally occurring G82E variant: functional properties and physiological implications

Human wild-type alanine:glyoxylate aminotransferase and its naturally occurring G82E variant: functional properties and physiological implications

http://www.wikidata.org/entity/Q24337369

about

Molecular defects of the glycine 41 variants of alanine glyoxylate aminotransferase associated with primary hyperoxaluria type I Active site and loop 4 movements within human glycolate oxidase: implications for substrate specificity and drug design Crystal structure of the S187F variant of human liver alanine: Aminotransferase associated with primary hyperoxaluria type I and its functional implications The Role of Protein Denaturation Energetics and Molecular Chaperones in the Aggregation and Mistargeting of Mutants Causing Primary Hyperoxaluria Type I Crystal structure of the ω-aminotransferase from Paracoccus denitrificans and its phylogenetic relationship with other class III aminotransferases that have biotechnological potential The consensus-based approach for gene/enzyme replacement therapies and crystallization strategies: the case of human alanine-glyoxylate aminotransferase Oligomeric State and Thermal Stability of Apo- and Holo- Human Ornithine δ-Aminotransferase.S81L and G170R mutations causing Primary Hyperoxaluria type I in homozygosis and heterozygosis: an example of positive interallelic complementation.Allele-specific characterization of alanine: glyoxylate aminotransferase variants associated with primary hyperoxaluria Active-Site Engineering of ω-Transaminase for Production of Unnatural Amino Acids Carrying a Side Chain Bulkier than an Ethyl Substituent.Rapid profiling of disease alleles using a tunable reporter of protein misfolding.Four of the most common mutations in primary hyperoxaluria type 1 unmask the cryptic mitochondrial targeting sequence of alanine:glyoxylate aminotransferase encoded by the polymorphic minor allele.Biochemical and computational approaches to improve the clinical treatment of dopa decarboxylase-related diseases: an overview Protein homeostasis defects of alanine-glyoxylate aminotransferase: new therapeutic strategies in primary hyperoxaluria type I.Role of low native state kinetic stability and interaction of partially unfolded states with molecular chaperones in the mitochondrial protein mistargeting associated with primary hyperoxaluria.Effects of alanine:glyoxylate aminotransferase variants and pyridoxine sensitivity on oxalate metabolism in a cell-based cytotoxicity assay.Structural mimicry between SLA/LP and Rickettsia surface antigens as a driver of autoimmune hepatitis: insights from an in silico study.Biochemical analyses are instrumental in identifying the impact of mutations on holo and/or apo-forms and on the region(s) of alanine:glyoxylate aminotransferase variants associated with primary hyperoxaluria type I.A Novel Pathway for Metabolism of the Cardiovascular Risk Factor Homoarginine by alanine:glyoxylate aminotransferase 2.Radiation damage at the active site of human alanine:glyoxylate aminotransferase reveals that the cofactor position is finely tuned during catalysis Molecular Insight into the Synergism between the Minor Allele of Human Liver Peroxisomal Alanine:Glyoxylate Aminotransferase and the F152I Mutation Recombinant production of eight human cytosolic aminotransferases and assessment of their potential involvement in glyoxylate metabolism.Correlation between the molecular effects of mutations at the dimer interface of alanine-glyoxylate aminotransferase leading to primary hyperoxaluria type I and the cellular response to vitamin B6.Folding Defects Leading to Primary Hyperoxaluria.Pyridoxamine and pyridoxal are more effective than pyridoxine in rescuing folding-defective variants of human alanine:glyoxylate aminotransferase causing primary hyperoxaluria type I.Structural and functional studies of Spr1654: an essential aminotransferase in teichoic acid biosynthesis in Streptococcus pneumoniae.Insulin resistance and glycine metabolism in humans.Evolutionary Divergent Suppressor Mutations in Conformational Diseases

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P2860

Human wild-type alanine:glyoxylate aminotransferase and its naturally occurring G82E variant: functional properties and physiological implications

http://www.wikidata.org/entity/Q24337369

description

2007 nî lūn-bûn

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2007 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2007 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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Human wild-type alanine:glyoxy ...... and physiological implications

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Human wild-type alanine:glyoxy ...... and physiological implications

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Human wild-type alanine:glyoxy ...... and physiological implications

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Human wild-type alanine:glyoxy ...... and physiological implications

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Human wild-type alanine:glyoxy ...... and physiological implications

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Human wild-type alanine:glyoxy ...... and physiological implications

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Human wild-type alanine:glyoxy ...... and physiological implications

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Human wild-type alanine:glyoxy ...... and physiological implications

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Human wild-type alanine:glyoxy ...... and physiological implications

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Human wild-type alanine:glyoxy ...... and physiological implications

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Human wild-type alanine:glyoxy ...... and physiological implications

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Human wild-type alanine:glyoxy ...... and physiological implications

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Human wild-type alanine:glyoxy ...... and physiological implications

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Alessandro Paiardini

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Barbara Cellini

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Carla Borri Voltattorni

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Mariarita Bertoldi

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Riccardo Montioli

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P2860

Identification of mutations associated with peroxisome-to-mitochondrion mistargeting of alanine/glyoxylate aminotransferase in primary hyperoxaluria type 1

Crystal structure of alanine:glyoxylate aminotransferase and the relationship between genotype and enzymatic phenotype in primary hyperoxaluria type 1

Modeling of the spatial structure of eukaryotic ornithine decarboxylases

Crystal structure of histidinol phosphate aminotransferase (HisC) from Escherichia coli, and its covalent complex with pyridoxal-5'-phosphate and l-histidinol phosphate

Structural studies of Salmonella typhimurium ArnB (PmrH) aminotransferase: a 4-amino-4-deoxy-L-arabinose lipopolysaccharide-modifying enzyme

How to measure and predict the molar absorption coefficient of a protein

Protein structure alignment by incremental combinatorial extension (CE) of the optimal path

Functional synergism between the most common polymorphism in human alanine:glyoxylate aminotransferase and four of the most common disease-causing mutations

A glycine-to-glutamate substitution abolishes alanine:glyoxylate aminotransferase catalytic activity in a subset of patients with primary hyperoxaluria type 1

Molecular etiology of primary hyperoxaluria type 1: new directions for treatment

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39-50

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2943309

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10.1042/BJ20070637

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1

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408

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2007-11-15T00:00:00Z

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17696873

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L-alanine catabolic process

Alanine--glyoxylate and serine--pyruvate aminotransferase

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2049084

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