Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase
about
Intestinal cell kinase (ICK) localizes to the crypt region and requires a dual phosphorylation site found in map kinasesActivation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRADInterleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12Cloning and expression patterns of two members of a novel protein-kinase-C-related kinase familyMolecular cloning of L-JAK, a Janus family protein-tyrosine kinase expressed in natural killer cells and activated leukocytesPhosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 proteinIdentification of a new family of human epithelial protein kinases containing two leucine/isoleucine-zipper domainsHuman spleen tyrosine kinase p72Syk associates with the Src-family kinase p53/56Lyn and a 120-kDa phosphoproteinTyrosine kinase JAK1 is associated with the granulocyte-colony-stimulating factor receptor and both become tyrosine-phosphorylated after receptor activationActivation of JAK2 kinase mediated by the interleukin 6 signal transducer gp130A tyrosine kinase profile of prostate carcinomaMast cell homeostasis and the JAK-STAT pathwayDirect association with and dephosphorylation of Jak2 kinase by the SH2-domain-containing protein tyrosine phosphatase SHP-1Identification of sequences required for the efficient localization of the focal adhesion kinase, pp125FAK, to cellular focal adhesions.Therapeutic targeting of Janus kinasesJak1 kinase is required for cell migrations and anterior specification in zebrafish embryosJanus kinases and signal transducers and activators of transcription: their roles in cytokine signaling, development and immunoregulation.Mechanisms of chronic JAK-STAT3-SOCS3 signaling in obesityModulation of Activation-Loop Phosphorylation by JAK Inhibitors Is Binding Mode DependentStructure of the pseudokinase-kinase domains from protein kinase TYK2 reveals a mechanism for Janus kinase (JAK) autoinhibitionMapping of a region within the N terminus of Jak1 involved in cytokine receptor interactionThe conserved box 1 motif of cytokine receptors is required for association with JAK kinasesExpression of Janus kinase 3 in human endothelial and other non-lymphoid and non-myeloid cellsRegions of the JAK2 tyrosine kinase required for coupling to the growth hormone receptorA kinase-deficient splice variant of the human JAK3 is expressed in hematopoietic and epithelial cancer cellsMolecular characterization of specific interactions between SHP-2 phosphatase and JAK tyrosine kinasesBrevilin A, a novel natural product, inhibits janus kinase activity and blocks STAT3 signaling in cancer cellsStructure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transductionMolecular characterization of an alpha interferon receptor 1 subunit (IFNaR1) domain required for TYK2 binding and signal transductionJanus kinase-dependent activation of insulin receptor substrate 1 in response to interleukin-4, oncostatin M, and the interferonsPhosphorylation and internalization of gp130 occur after IL-6 activation of Jak2 kinase in hepatocytesIdentification of an interferon-gamma receptor alpha chain sequence required for JAK-1 bindingInterferon-alpha-dependent activation of Tyk2 requires phosphorylation of positive regulatory tyrosines by another kinaseA novel nonreceptor tyrosine kinase, Srm: cloning and targeted disruption.Biology and clinical management of myeloproliferative neoplasms and development of the JAK inhibitor ruxolitinibTransforming JAK1 mutations exhibit differential signalling, FERM domain requirements and growth responses to interferon-γ.Autosomal SCID caused by a point mutation in the N-terminus of Jak3: mapping of the Jak3-receptor interaction domain.The molecular regulation of Janus kinase (JAK) activationComplex effects of naturally occurring mutations in the JAK3 pseudokinase domain: evidence for interactions between the kinase and pseudokinase domains.The JAK2 exon 12 mutations: a comprehensive review.
P2860
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P2860
Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase
description
1991 nî lūn-bûn
@nan
1991 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1991 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1991年の論文
@ja
1991年論文
@yue
1991年論文
@zh-hant
1991年論文
@zh-hk
1991年論文
@zh-mo
1991年論文
@zh-tw
1991年论文
@wuu
name
Two novel protein-tyrosine kin ...... a new class of protein kinase
@ast
Two novel protein-tyrosine kin ...... a new class of protein kinase
@en
Two novel protein-tyrosine kin ...... a new class of protein kinase
@en-gb
Two novel protein-tyrosine kin ...... a new class of protein kinase
@nl
type
label
Two novel protein-tyrosine kin ...... a new class of protein kinase
@ast
Two novel protein-tyrosine kin ...... a new class of protein kinase
@en
Two novel protein-tyrosine kin ...... a new class of protein kinase
@en-gb
Two novel protein-tyrosine kin ...... a new class of protein kinase
@nl
prefLabel
Two novel protein-tyrosine kin ...... a new class of protein kinase
@ast
Two novel protein-tyrosine kin ...... a new class of protein kinase
@en
Two novel protein-tyrosine kin ...... a new class of protein kinase
@en-gb
Two novel protein-tyrosine kin ...... a new class of protein kinase
@nl
P2093
P2860
P921
P3181
P356
P1476
Two novel protein-tyrosine kin ...... a new class of protein kinase
@en
P2093
P2860
P304
P3181
P356
10.1128/MCB.11.4.2057
P407
P577
1991-04-01T00:00:00Z