Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction
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Fyn associates with Cbl and phosphorylates tyrosine 731 in Cbl, a binding site for phosphatidylinositol 3-kinaseInterleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12Growth hormone-promoted tyrosyl phosphorylation of SHC proteins and SHC association with Grb2Growth hormone, interferon-gamma, and leukemia inhibitory factor promoted tyrosyl phosphorylation of insulin receptor substrate-1Regulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1.Protein tyrosine phosphatase 1B negatively regulates macrophage development through CSF-1 signaling.Differential binding to and regulation of JAK2 by the SH2 domain and N-terminal region of SH2-bbetaKinase-negative mutants of JAK1 can sustain interferon-gamma-inducible gene expression but not an antiviral stateTyrosine kinase JAK1 is associated with the granulocyte-colony-stimulating factor receptor and both become tyrosine-phosphorylated after receptor activationActivation of JAK2 kinase mediated by the interleukin 6 signal transducer gp130Tyrosine phosphorylation of p95Vav in myeloid cells is regulated by GM-CSF, IL-3 and steel factor and is constitutively increased by p210BCR/ABLTec kinase associates with c-kit and is tyrosine phosphorylated and activated following stem cell factor bindingA critical cytoplasmic domain of the interleukin-5 (IL-5) receptor alpha chain and its function in IL-5-mediated growth signal transductionJAK2 associates with the beta c chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requires the membrane-proximal regionIdentification of SH2-Bbeta as a substrate of the tyrosine kinase JAK2 involved in growth hormone signalingDirect association with and dephosphorylation of Jak2 kinase by the SH2-domain-containing protein tyrosine phosphatase SHP-1Human interleukin-3 (IL-3) induces disulfide-linked IL-3 receptor alpha- and beta-chain heterodimerization, which is required for receptor activation but not high-affinity bindingFunctional regions of the mouse interleukin-10 receptor cytoplasmic domainOncostatin M induces association of Grb2 with Janus kinase JAK2 in multiple myeloma cellsTyrosines 868, 966, and 972 in the kinase domain of JAK2 are autophosphorylated and required for maximal JAK2 kinase activityActivating point mutations in the common beta subunit of the human GM-CSF, IL-3 and IL-5 receptors suggest the involvement of beta subunit dimerization and cell type-specific molecules in signallingThe conserved box 1 motif of cytokine receptors is required for association with JAK kinasesStat4, a novel gamma interferon activation site-binding protein expressed in early myeloid differentiationErythropoietin induces the tyrosine phosphorylation of insulin receptor substrate-2. An alternate pathway for erythropoietin-induced phosphatidylinositol 3-kinase activationRegions of the JAK2 tyrosine kinase required for coupling to the growth hormone receptorInterleukin-9 induces tyrosine phosphorylation of insulin receptor substrate-1 via JAK tyrosine kinasesA kinase-deficient splice variant of the human JAK3 is expressed in hematopoietic and epithelial cancer cellsGrowth hormone, interferon-gamma, and leukemia inhibitory factor utilize insulin receptor substrate-2 in intracellular signalingPhosphorylation and activation of the DNA binding activity of purified Stat1 by the Janus protein-tyrosine kinases and the epidermal growth factor receptorMolecular characterization of specific interactions between SHP-2 phosphatase and JAK tyrosine kinasesNegative cross-talk between interleukin-3 and interleukin-11 is mediated by suppressor of cytokine signalling-3 (SOCS-3)Tyrosine 813 is a site of JAK2 autophosphorylation critical for activation of JAK2 by SH2-B betaDifferential biological activity of disease-associated JAK2 mutantsSHP1 and SHP2 protein-tyrosine phosphatases associate with betac after interleukin-3-induced receptor tyrosine phosphorylation. Identification of potential binding sites and substratesPhosphorylation and internalization of gp130 occur after IL-6 activation of Jak2 kinase in hepatocytesPlatelet-derived growth factor induces phosphorylation of multiple JAK family kinases and STAT proteinsInterferon-alpha-dependent activation of Tyk2 requires phosphorylation of positive regulatory tyrosines by another kinaseBinding of src-like kinases to the beta-subunit of the interleukin-3 receptor.Abrogation of interleukin-3 dependence of myeloid cells by the v-src oncogene requires SH2 and SH3 domains which specify activation of STATsIL-5 receptor-mediated tyrosine phosphorylation of SH2/SH3-containing proteins and activation of Bruton's tyrosine and Janus 2 kinases.
P2860
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P2860
Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction
description
1993 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
article publié dans les Procee ...... f the United States of America
@fr
artículu científicu espublizáu en 1993
@ast
im September 1993 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1993/09/15)
@sk
vědecký článek publikovaný v roce 1993
@cs
wetenschappelijk artikel (gepubliceerd op 1993/09/15)
@nl
наукова стаття, опублікована у вересні 1993
@uk
name
Structure of the murine Jak2 p ...... erleukin 3 signal transduction
@ast
Structure of the murine Jak2 p ...... erleukin 3 signal transduction
@en
Structure of the murine Jak2 p ...... erleukin 3 signal transduction
@nl
type
label
Structure of the murine Jak2 p ...... erleukin 3 signal transduction
@ast
Structure of the murine Jak2 p ...... erleukin 3 signal transduction
@en
Structure of the murine Jak2 p ...... erleukin 3 signal transduction
@nl
prefLabel
Structure of the murine Jak2 p ...... erleukin 3 signal transduction
@ast
Structure of the murine Jak2 p ...... erleukin 3 signal transduction
@en
Structure of the murine Jak2 p ...... erleukin 3 signal transduction
@nl
P2093
P2860
P921
P356
P1476
Structure of the murine Jak2 p ...... erleukin 3 signal transduction
@en
P2093
B. A. Witthuhn
F. W. Quelle
J. L. Cleveland
J. N. Ihle
O. Silvennoinen
P2860
P304
P356
10.1073/PNAS.90.18.8429
P407
P577
1993-09-15T00:00:00Z