WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing
about
Structural insights into DNA repair by RNase T--an exonuclease processing 3' end of structured DNA in repair pathwaysA genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repairUp-regulation of WRN and DNA ligase IIIalpha in chronic myeloid leukemia: consequences for the repair of DNA double-strand breaksHuman premature aging, DNA repair and RecQ helicasesMetals in biology: defining metalloproteomesDNA-PK: a dynamic enzyme in a versatile DSB repair pathwayCrystal structure of the HRDC domain of human Werner syndrome protein, WRNThe crystal structure of TREX1 explains the 3' nucleotide specificity and reveals a polyproline II helix for protein partneringDNA apurinic-apyrimidinic site binding and excision by endonuclease IVStructural basis for RNA trimming by RNase T in stable RNA 3'-end maturationThe Werner syndrome helicase/exonuclease processes mobile D-loops through branch migration and degradationX-ray solution scattering (SAXS) combined with crystallography and computation: defining accurate macromolecular structures, conformations and assemblies in solutionWRN regulates pathway choice between classical and alternative non-homologous end joiningA fine-scale dissection of the DNA double-strand break repair machinery and its implications for breast cancer therapy.RISC-interacting clearing 3'- 5' exoribonucleases (RICEs) degrade uridylated cleavage fragments to maintain functional RISC in Arabidopsis thaliana.WRN participates in translesion synthesis pathway through interaction with NBS1The use of divalent metal ions by type II topoisomerases.Identification of a coiled coil in werner syndrome protein that facilitates multimerization and promotes exonuclease processivityThe RAD9-RAD1-HUS1 (9.1.1) complex interacts with WRN and is crucial to regulate its response to replication fork stallingDNA2 cooperates with the WRN and BLM RecQ helicases to mediate long-range DNA end resection in human cellsCatalytic activities of Werner protein are affected by adduction with 4-hydroxy-2-nonenalRECQ helicase RECQL4 participates in non-homologous end joining and interacts with the Ku complexStructures of CRISPR Cas3 offer mechanistic insights into Cascade-activated DNA unwinding and degradationInhibition of helicase activity by a small molecule impairs Werner syndrome helicase (WRN) function in the cellular response to DNA damage or replication stress.Non-homologous end joining: Common interaction sites and exchange of multiple factors in the DNA repair process.Werner protein cooperates with the XRCC4-DNA ligase IV complex in end-processingThe structural biochemistry of the superoxide dismutases.Sit down, relax and unwind: structural insights into RecQ helicase mechanisms.The DNA repair endonuclease XPG interacts directly and functionally with the WRN helicase defective in Werner syndromeCrystal structure of the protein from Arabidopsis thaliana gene At5g06450, a putative DnaQ-like exonuclease domain-containing protein with homohexameric assembly.Developing master keys to brain pathology, cancer and aging from the structural biology of proteins controlling reactive oxygen species and DNA repair.Mechanism of cluster DNA damage repair in response to high-atomic number and energy particles radiation.Biochemical mechanism of DSB end resection and its regulation.DNA helicases involved in DNA repair and their roles in cancerHuman RecQ helicases in DNA repair, recombination, and replication.DNA binding residues in the RQC domain of Werner protein are critical for its catalytic activities.Enhancement of human DNA polymerase η activity and fidelity is dependent upon a bipartite interaction with the Werner syndrome proteinThe role of DNA exonucleases in protecting genome stability and their impact on ageing.Mechanisms of RecQ helicases in pathways of DNA metabolism and maintenance of genomic stabilityNonenzymatic role for WRN in preserving nascent DNA strands after replication stress.
P2860
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P2860
WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing
description
2006 nî lūn-bûn
@nan
2006 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
WRN exonuclease structure and ...... ing role in DNA end processing
@ast
WRN exonuclease structure and ...... ing role in DNA end processing
@en
WRN exonuclease structure and ...... ing role in DNA end processing
@en-gb
WRN exonuclease structure and ...... ing role in DNA end processing
@nl
type
label
WRN exonuclease structure and ...... ing role in DNA end processing
@ast
WRN exonuclease structure and ...... ing role in DNA end processing
@en
WRN exonuclease structure and ...... ing role in DNA end processing
@en-gb
WRN exonuclease structure and ...... ing role in DNA end processing
@nl
prefLabel
WRN exonuclease structure and ...... ing role in DNA end processing
@ast
WRN exonuclease structure and ...... ing role in DNA end processing
@en
WRN exonuclease structure and ...... ing role in DNA end processing
@en-gb
WRN exonuclease structure and ...... ing role in DNA end processing
@nl
P2093
P3181
P356
P1476
WRN exonuclease structure and ...... ing role in DNA end processing
@en
P2093
Aroumougame Asaithamby
Chiharu Hitomi
David J Chen
J Jefferson P Perry
Priscilla K Cooper
Seungil Han
Steven M Yannone
P2888
P304
P3181
P356
10.1038/NSMB1088
P407
P577
2006-04-23T00:00:00Z
P5875
P6179
1007138952